Antidiabetic Actions of an Estrogen Receptor beta Selective Agonist
(2013) In Diabetes 62(6). p.2015-2025- Abstract
- The estrogen receptor beta (ER beta) is emerging as an important player in the physiology of the endocrine pancreas. We evaluated the role and antidiabetic actions of the ER beta selective agonist WAY200070 as an insulinotropic molecule. We demonstrate that WAY200070 enhances glucose-stimulated insulin secretion both in mouse and human islets. In vivo experiments showed that a single administration of WAY200070 leads to an increase in plasma insulin levels with a concomitant improved response to a glucose load. Two-week treatment administration increased glucose-induced insulin release and pancreatic beta-cell mass and improved glucose and insulin sensitivity. In addition, streptozotocin-nicotinamide-induced diabetic mice treated with... (More)
- The estrogen receptor beta (ER beta) is emerging as an important player in the physiology of the endocrine pancreas. We evaluated the role and antidiabetic actions of the ER beta selective agonist WAY200070 as an insulinotropic molecule. We demonstrate that WAY200070 enhances glucose-stimulated insulin secretion both in mouse and human islets. In vivo experiments showed that a single administration of WAY200070 leads to an increase in plasma insulin levels with a concomitant improved response to a glucose load. Two-week treatment administration increased glucose-induced insulin release and pancreatic beta-cell mass and improved glucose and insulin sensitivity. In addition, streptozotocin-nicotinamide-induced diabetic mice treated with WAY200070 exhibited a significant improvement in plasma insulin levels and glucose tolerance as well as a regeneration of pancreatic beta-cell mass. Studies performed in db/db mice demonstrated that this compound restored first-phase insulin secretion and enhanced pancreatic beta-cell mass. We conclude that ER beta agonists should be considered as new targets for the treatment of diabetes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3927066
- author
- Alonso-Magdalena, Paloma ; Ropero, Ana B. ; Garcia-Arevalo, Marta ; Soriano, Sergi ; Quesada, Ivan ; Jabar Muhammed, Sarheed LU ; Salehi, S Albert LU ; Gustafsson, Jan-Ake and Nadal, Angel
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes
- volume
- 62
- issue
- 6
- pages
- 2015 - 2025
- publisher
- American Diabetes Association Inc.
- external identifiers
-
- wos:000319845000031
- scopus:84878237251
- pmid:23349481
- ISSN
- 1939-327X
- DOI
- 10.2337/db12-1562
- language
- English
- LU publication?
- yes
- id
- fe2f4a6a-1e02-4741-a890-89d9989a98c1 (old id 3927066)
- date added to LUP
- 2016-04-01 13:28:11
- date last changed
- 2022-01-27 19:25:17
@article{fe2f4a6a-1e02-4741-a890-89d9989a98c1, abstract = {{The estrogen receptor beta (ER beta) is emerging as an important player in the physiology of the endocrine pancreas. We evaluated the role and antidiabetic actions of the ER beta selective agonist WAY200070 as an insulinotropic molecule. We demonstrate that WAY200070 enhances glucose-stimulated insulin secretion both in mouse and human islets. In vivo experiments showed that a single administration of WAY200070 leads to an increase in plasma insulin levels with a concomitant improved response to a glucose load. Two-week treatment administration increased glucose-induced insulin release and pancreatic beta-cell mass and improved glucose and insulin sensitivity. In addition, streptozotocin-nicotinamide-induced diabetic mice treated with WAY200070 exhibited a significant improvement in plasma insulin levels and glucose tolerance as well as a regeneration of pancreatic beta-cell mass. Studies performed in db/db mice demonstrated that this compound restored first-phase insulin secretion and enhanced pancreatic beta-cell mass. We conclude that ER beta agonists should be considered as new targets for the treatment of diabetes.}}, author = {{Alonso-Magdalena, Paloma and Ropero, Ana B. and Garcia-Arevalo, Marta and Soriano, Sergi and Quesada, Ivan and Jabar Muhammed, Sarheed and Salehi, S Albert and Gustafsson, Jan-Ake and Nadal, Angel}}, issn = {{1939-327X}}, language = {{eng}}, number = {{6}}, pages = {{2015--2025}}, publisher = {{American Diabetes Association Inc.}}, series = {{Diabetes}}, title = {{Antidiabetic Actions of an Estrogen Receptor beta Selective Agonist}}, url = {{http://dx.doi.org/10.2337/db12-1562}}, doi = {{10.2337/db12-1562}}, volume = {{62}}, year = {{2013}}, }