Temporal dynamics of woolly mammoth genome erosion prior to extinction
(2024) In Cell 187(14). p.13-3540- Abstract
A number of species have recently recovered from near-extinction. Although these species have avoided the immediate extinction threat, their long-term viability remains precarious due to the potential genetic consequences of population declines, which are poorly understood on a timescale beyond a few generations. Woolly mammoths (Mammuthus primigenius) became isolated on Wrangel Island around 10,000 years ago and persisted for over 200 generations before becoming extinct around 4,000 years ago. To study the evolutionary processes leading up to the mammoths’ extinction, we analyzed 21 Siberian woolly mammoth genomes. Our results show that the population recovered quickly from a severe bottleneck and remained demographically stable during... (More)
A number of species have recently recovered from near-extinction. Although these species have avoided the immediate extinction threat, their long-term viability remains precarious due to the potential genetic consequences of population declines, which are poorly understood on a timescale beyond a few generations. Woolly mammoths (Mammuthus primigenius) became isolated on Wrangel Island around 10,000 years ago and persisted for over 200 generations before becoming extinct around 4,000 years ago. To study the evolutionary processes leading up to the mammoths’ extinction, we analyzed 21 Siberian woolly mammoth genomes. Our results show that the population recovered quickly from a severe bottleneck and remained demographically stable during the ensuing six millennia. We find that mildly deleterious mutations gradually accumulated, whereas highly deleterious mutations were purged, suggesting ongoing inbreeding depression that lasted for hundreds of generations. The time-lag between demographic and genetic recovery has wide-ranging implications for conservation management of recently bottlenecked populations.
(Less)
- author
- organization
- publishing date
- 2024-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ancient DNA, bottleneck, climate, extinction, inbreeding, Mammuthus primigenius, mutation load, paleogenomics, woolly mammoth, Wrangel Island
- in
- Cell
- volume
- 187
- issue
- 14
- pages
- 13 - 3540
- publisher
- Cell Press
- external identifiers
-
- pmid:38942016
- scopus:85197516018
- ISSN
- 0092-8674
- DOI
- 10.1016/j.cell.2024.05.033
- language
- English
- LU publication?
- yes
- id
- fe3920da-9d0e-4d61-822f-6ee083b577f8
- date added to LUP
- 2024-09-23 14:32:21
- date last changed
- 2024-10-15 13:54:09
@article{fe3920da-9d0e-4d61-822f-6ee083b577f8, abstract = {{<p>A number of species have recently recovered from near-extinction. Although these species have avoided the immediate extinction threat, their long-term viability remains precarious due to the potential genetic consequences of population declines, which are poorly understood on a timescale beyond a few generations. Woolly mammoths (Mammuthus primigenius) became isolated on Wrangel Island around 10,000 years ago and persisted for over 200 generations before becoming extinct around 4,000 years ago. To study the evolutionary processes leading up to the mammoths’ extinction, we analyzed 21 Siberian woolly mammoth genomes. Our results show that the population recovered quickly from a severe bottleneck and remained demographically stable during the ensuing six millennia. We find that mildly deleterious mutations gradually accumulated, whereas highly deleterious mutations were purged, suggesting ongoing inbreeding depression that lasted for hundreds of generations. The time-lag between demographic and genetic recovery has wide-ranging implications for conservation management of recently bottlenecked populations.</p>}}, author = {{Dehasque, Marianne and Morales, Hernán E and Díez-Del-Molino, David and Pečnerová, Patrícia and Chacón-Duque, J Camilo and Kanellidou, Foteini and Muller, Héloïse and Plotnikov, Valerii and Protopopov, Albert and Tikhonov, Alexei and Nikolskiy, Pavel and Danilov, Gleb K and Giannì, Maddalena and van der Sluis, Laura and Higham, Tom and Heintzman, Peter D and Oskolkov, Nikolay and Gilbert, M Thomas P and Götherström, Anders and van der Valk, Tom and Vartanyan, Sergey and Dalén, Love}}, issn = {{0092-8674}}, keywords = {{ancient DNA; bottleneck; climate; extinction; inbreeding; Mammuthus primigenius; mutation load; paleogenomics; woolly mammoth; Wrangel Island}}, language = {{eng}}, number = {{14}}, pages = {{13--3540}}, publisher = {{Cell Press}}, series = {{Cell}}, title = {{Temporal dynamics of woolly mammoth genome erosion prior to extinction}}, url = {{http://dx.doi.org/10.1016/j.cell.2024.05.033}}, doi = {{10.1016/j.cell.2024.05.033}}, volume = {{187}}, year = {{2024}}, }