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ISPAD Clinical Practice Consensus Guidelines 2024 : Screening, Staging, and Strategies to Preserve Beta-Cell Function in Children and Adolescents with Type 1 Diabetes

Haller, Michael J ; Bell, Kirstine J ; Besser, Rachel E J ; Casteels, Kristina ; Couper, Jenny J ; Craig, Maria E ; Elding Larsson, Helena LU orcid ; Jacobsen, Laura ; Lange, Karin and Oron, Tal , et al. (2025) In Hormone Research in Paediatrics 97(6). p.529-545
Abstract

The International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines represent a rich repository that serves as the only comprehensive set of clinical recommendations for children, adolescents, and young adults living with diabetes worldwide. This guideline serves as an update to the 2022 ISPAD consensus guideline on staging for type 1 diabetes (T1D). Key additions include an evidence-based summary of recommendations for screening for risk of T1D and monitoring those with early-stage T1D. In addition, a review of clinical trials designed to delay progression to Stage 3 T1D and efforts seeking to preserve beta-cell function in those with Stage 3 T1D are included. Lastly, opportunities and challenges associated with the... (More)

The International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines represent a rich repository that serves as the only comprehensive set of clinical recommendations for children, adolescents, and young adults living with diabetes worldwide. This guideline serves as an update to the 2022 ISPAD consensus guideline on staging for type 1 diabetes (T1D). Key additions include an evidence-based summary of recommendations for screening for risk of T1D and monitoring those with early-stage T1D. In addition, a review of clinical trials designed to delay progression to Stage 3 T1D and efforts seeking to preserve beta-cell function in those with Stage 3 T1D are included. Lastly, opportunities and challenges associated with the recent US Food and Drug Administration (FDA) approval of teplizumab as an immunotherapy to delay progression are discussed. The International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines represent a rich repository that serves as the only comprehensive set of clinical recommendations for children, adolescents, and young adults living with diabetes worldwide. This guideline serves as an update to the 2022 ISPAD consensus guideline on staging for type 1 diabetes (T1D). Key additions include an evidence-based summary of recommendations for screening for risk of T1D and monitoring those with early-stage T1D. In addition, a review of clinical trials designed to delay progression to Stage 3 T1D and efforts seeking to preserve beta-cell function in those with Stage 3 T1D are included. Lastly, opportunities and challenges associated with the recent US Food and Drug Administration (FDA) approval of teplizumab as an immunotherapy to delay progression are discussed.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Humans, Diabetes Mellitus, Type 1/therapy, Adolescent, Child, Insulin-Secreting Cells/pathology, Female, Societies, Medical/standards, Male
in
Hormone Research in Paediatrics
volume
97
issue
6
pages
17 pages
publisher
Karger
external identifiers
  • scopus:85217152332
  • pmid:39662065
ISSN
1663-2826
DOI
10.1159/000543035
language
English
LU publication?
yes
additional info
© 2024 The Author(s). Published by S. Karger AG, Basel.
id
fe45c69c-612b-419c-9a71-33965ab65dff
date added to LUP
2025-02-27 11:53:20
date last changed
2025-05-23 11:37:39
@article{fe45c69c-612b-419c-9a71-33965ab65dff,
  abstract     = {{<p>The International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines represent a rich repository that serves as the only comprehensive set of clinical recommendations for children, adolescents, and young adults living with diabetes worldwide. This guideline serves as an update to the 2022 ISPAD consensus guideline on staging for type 1 diabetes (T1D). Key additions include an evidence-based summary of recommendations for screening for risk of T1D and monitoring those with early-stage T1D. In addition, a review of clinical trials designed to delay progression to Stage 3 T1D and efforts seeking to preserve beta-cell function in those with Stage 3 T1D are included. Lastly, opportunities and challenges associated with the recent US Food and Drug Administration (FDA) approval of teplizumab as an immunotherapy to delay progression are discussed. The International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines represent a rich repository that serves as the only comprehensive set of clinical recommendations for children, adolescents, and young adults living with diabetes worldwide. This guideline serves as an update to the 2022 ISPAD consensus guideline on staging for type 1 diabetes (T1D). Key additions include an evidence-based summary of recommendations for screening for risk of T1D and monitoring those with early-stage T1D. In addition, a review of clinical trials designed to delay progression to Stage 3 T1D and efforts seeking to preserve beta-cell function in those with Stage 3 T1D are included. Lastly, opportunities and challenges associated with the recent US Food and Drug Administration (FDA) approval of teplizumab as an immunotherapy to delay progression are discussed.</p>}},
  author       = {{Haller, Michael J and Bell, Kirstine J and Besser, Rachel E J and Casteels, Kristina and Couper, Jenny J and Craig, Maria E and Elding Larsson, Helena and Jacobsen, Laura and Lange, Karin and Oron, Tal and Sims, Emily K and Speake, Cate and Tosur, Mustafa and Ulivi, Francesca and Ziegler, Anette-G and Wherrett, Diane K and Marcovecchio, M Loredana}},
  issn         = {{1663-2826}},
  keywords     = {{Humans; Diabetes Mellitus, Type 1/therapy; Adolescent; Child; Insulin-Secreting Cells/pathology; Female; Societies, Medical/standards; Male}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{529--545}},
  publisher    = {{Karger}},
  series       = {{Hormone Research in Paediatrics}},
  title        = {{ISPAD Clinical Practice Consensus Guidelines 2024 : Screening, Staging, and Strategies to Preserve Beta-Cell Function in Children and Adolescents with Type 1 Diabetes}},
  url          = {{http://dx.doi.org/10.1159/000543035}},
  doi          = {{10.1159/000543035}},
  volume       = {{97}},
  year         = {{2025}},
}