Dynamic glucose enhanced imaging using direct water saturation
Knutsson, Linda LU
; Yadav, Nirbhay N
; Mohammed Ali, Sajad
LU
; Kamson, David Olayinka
; Demetriou, Eleni
; Seidemo, Anina
LU
; Blair, Lindsay
; Lin, Doris D
; Laterra, John
and van Zijl, Peter C M
(2025)
In Magnetic Resonance in Medicine
- Abstract
PURPOSE: Dynamic glucose enhanced (DGE) MRI studies employ CEST or spin lock (CESL) to study glucose uptake. Currently, these methods are hampered by low effect size and sensitivity to motion. To overcome this, we propose to utilize exchange-based linewidth (LW) broadening of the direct water saturation (DS) curve of the water saturation spectrum (Z-spectrum) during and after glucose infusion (DS-DGE MRI).
METHODS: To estimate the glucose-infusion-induced LW changes (ΔLW), Bloch-McConnell simulations were performed for normoglycemia and hyperglycemia in blood, gray matter (GM), white matter (WM), CSF, and malignant tumor tissue. Whole-brain DS-DGE imaging was implemented at 3 T using dynamic Z-spectral acquisitions (1.2 s per... (More)
PURPOSE: Dynamic glucose enhanced (DGE) MRI studies employ CEST or spin lock (CESL) to study glucose uptake. Currently, these methods are hampered by low effect size and sensitivity to motion. To overcome this, we propose to utilize exchange-based linewidth (LW) broadening of the direct water saturation (DS) curve of the water saturation spectrum (Z-spectrum) during and after glucose infusion (DS-DGE MRI).
METHODS: To estimate the glucose-infusion-induced LW changes (ΔLW), Bloch-McConnell simulations were performed for normoglycemia and hyperglycemia in blood, gray matter (GM), white matter (WM), CSF, and malignant tumor tissue. Whole-brain DS-DGE imaging was implemented at 3 T using dynamic Z-spectral acquisitions (1.2 s per offset frequency, 38 s per spectrum) and assessed on four brain tumor patients using infusion of 35 g of D-glucose. To assess ΔLW, a deep learning-based Lorentzian fitting approach was used on voxel-based DS spectra acquired before, during, and post-infusion. Area-under-the-curve (AUC) images, obtained from the dynamic ΔLW time curves, were compared qualitatively to perfusion-weighted imaging parametric maps.
RESULTS: In simulations, ΔLW was 1.3%, 0.30%, 0.29/0.34%, 7.5%, and 13% in arterial blood, venous blood, GM/WM, malignant tumor tissue, and CSF, respectively. In vivo, ΔLW was approximately 1% in GM/WM, 5% to 20% for different tumor types, and 40% in CSF. The resulting DS-DGE AUC maps clearly outlined lesion areas.
CONCLUSIONS: DS-DGE MRI is highly promising for assessing D-glucose uptake. Initial results in brain tumor patients show high-quality AUC maps of glucose-induced line broadening and DGE-based lesion enhancement similar and/or complementary to perfusion-weighted imaging.
(Less)
- author
- Knutsson, Linda
LU
; Yadav, Nirbhay N
; Mohammed Ali, Sajad
LU
; Kamson, David Olayinka
; Demetriou, Eleni
; Seidemo, Anina
LU
; Blair, Lindsay
; Lin, Doris D
; Laterra, John
and van Zijl, Peter C M
- organization
- publishing date
- 2025-03-17
- type
- Contribution to journal
- publication status
- epub
- subject
- in
- Magnetic Resonance in Medicine
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:105000198564
- pmid:40096575
- ISSN
- 1522-2594
- DOI
- 10.1002/mrm.30447
- language
- English
- LU publication?
- yes
- additional info
- © 2025 The Author(s). Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.
- id
- fe8d2cd7-706a-425d-b3a5-40532da319b3
- date added to LUP
- 2025-03-21 09:39:37
- date last changed
- 2025-07-11 08:15:50
@article{fe8d2cd7-706a-425d-b3a5-40532da319b3,
abstract = {{<p>PURPOSE: Dynamic glucose enhanced (DGE) MRI studies employ CEST or spin lock (CESL) to study glucose uptake. Currently, these methods are hampered by low effect size and sensitivity to motion. To overcome this, we propose to utilize exchange-based linewidth (LW) broadening of the direct water saturation (DS) curve of the water saturation spectrum (Z-spectrum) during and after glucose infusion (DS-DGE MRI).</p><p>METHODS: To estimate the glucose-infusion-induced LW changes (ΔLW), Bloch-McConnell simulations were performed for normoglycemia and hyperglycemia in blood, gray matter (GM), white matter (WM), CSF, and malignant tumor tissue. Whole-brain DS-DGE imaging was implemented at 3 T using dynamic Z-spectral acquisitions (1.2 s per offset frequency, 38 s per spectrum) and assessed on four brain tumor patients using infusion of 35 g of D-glucose. To assess ΔLW, a deep learning-based Lorentzian fitting approach was used on voxel-based DS spectra acquired before, during, and post-infusion. Area-under-the-curve (AUC) images, obtained from the dynamic ΔLW time curves, were compared qualitatively to perfusion-weighted imaging parametric maps.</p><p>RESULTS: In simulations, ΔLW was 1.3%, 0.30%, 0.29/0.34%, 7.5%, and 13% in arterial blood, venous blood, GM/WM, malignant tumor tissue, and CSF, respectively. In vivo, ΔLW was approximately 1% in GM/WM, 5% to 20% for different tumor types, and 40% in CSF. The resulting DS-DGE AUC maps clearly outlined lesion areas.</p><p>CONCLUSIONS: DS-DGE MRI is highly promising for assessing D-glucose uptake. Initial results in brain tumor patients show high-quality AUC maps of glucose-induced line broadening and DGE-based lesion enhancement similar and/or complementary to perfusion-weighted imaging.</p>}},
author = {{Knutsson, Linda and Yadav, Nirbhay N and Mohammed Ali, Sajad and Kamson, David Olayinka and Demetriou, Eleni and Seidemo, Anina and Blair, Lindsay and Lin, Doris D and Laterra, John and van Zijl, Peter C M}},
issn = {{1522-2594}},
language = {{eng}},
month = {{03}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Magnetic Resonance in Medicine}},
title = {{Dynamic glucose enhanced imaging using direct water saturation}},
url = {{http://dx.doi.org/10.1002/mrm.30447}},
doi = {{10.1002/mrm.30447}},
year = {{2025}},
}