Amino acids and the changing face of the α-cell
Hamilton, Alexander LU ; Eliasson, Lena LU
and Knudsen, Jakob G.
(2023)
In Peptides
166.
- Abstract
Glucagon has long been defined by its glucogenic action and as a result α-cells have been characterised based largely on their interaction with glucose. Recent findings have challenged this preconception, bringing to the fore the significant role glucagon plays in amino acid breakdown and underlining the importance of amino acids in glucagon secretion. The challenge that remains is defining the mechanism that underlie these effects - understanding which amino acids are most important, how they act on the α-cell and how their actions integrate with other fuels such as glucose and fatty acids. This review will describe the current relationship between amino acids and glucagon and how we can use this knowledge to redefine the α-cell.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/fe913b6e-db7e-4da6-a5ee-9923ac2afa2a
- author
- Hamilton, Alexander
LU
; Eliasson, Lena
LU
and Knudsen, Jakob G.
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Alpha cell, Amino acids, Glucagon, Liver-α cell axis, Type 2 diabetes
- in
- Peptides
- volume
- 166
- article number
- 171039
- publisher
- Elsevier
- external identifiers
-
- pmid:37295651
- scopus:85161702045
- ISSN
- 0196-9781
- DOI
- 10.1016/j.peptides.2023.171039
- language
- English
- LU publication?
- yes
- id
- fe913b6e-db7e-4da6-a5ee-9923ac2afa2a
- date added to LUP
- 2023-09-11 13:33:48
- date last changed
- 2024-04-20 03:03:01
@article{fe913b6e-db7e-4da6-a5ee-9923ac2afa2a,
abstract = {{<p>Glucagon has long been defined by its glucogenic action and as a result α-cells have been characterised based largely on their interaction with glucose. Recent findings have challenged this preconception, bringing to the fore the significant role glucagon plays in amino acid breakdown and underlining the importance of amino acids in glucagon secretion. The challenge that remains is defining the mechanism that underlie these effects - understanding which amino acids are most important, how they act on the α-cell and how their actions integrate with other fuels such as glucose and fatty acids. This review will describe the current relationship between amino acids and glucagon and how we can use this knowledge to redefine the α-cell.</p>}},
author = {{Hamilton, Alexander and Eliasson, Lena and Knudsen, Jakob G.}},
issn = {{0196-9781}},
keywords = {{Alpha cell; Amino acids; Glucagon; Liver-α cell axis; Type 2 diabetes}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Peptides}},
title = {{Amino acids and the changing face of the α-cell}},
url = {{http://dx.doi.org/10.1016/j.peptides.2023.171039}},
doi = {{10.1016/j.peptides.2023.171039}},
volume = {{166}},
year = {{2023}},
}