Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk
Sanches, Jose Marcos LU ; Zhao, Li Na ; Salehi, Albert LU
; Wollheim, Claes B
LU
and Kaldis, Philipp
LU
(2023)
In The FEBS Journal
290(3).
p.620-648
- Abstract
Diabetes is a complex and multifactorial disease that affects millions of people worldwide, reducing the quality of life significantly, and results in grave consequences for our health care system. In type 2 diabetes (T2D), the lack of β-cell compensatory mechanisms overcoming peripherally developed insulin resistance is a paramount factor leading to disturbed blood glucose levels and lipid metabolism. Impaired β-cell functions and insulin resistance have been studied extensively resulting in a good understanding of these pathways but much less is known about interorgan crosstalk, which we define as signaling between tissues by secreted factors. Besides hormones and organokines, dysregulated blood glucose and long-lasting hyperglycemia... (More)
Diabetes is a complex and multifactorial disease that affects millions of people worldwide, reducing the quality of life significantly, and results in grave consequences for our health care system. In type 2 diabetes (T2D), the lack of β-cell compensatory mechanisms overcoming peripherally developed insulin resistance is a paramount factor leading to disturbed blood glucose levels and lipid metabolism. Impaired β-cell functions and insulin resistance have been studied extensively resulting in a good understanding of these pathways but much less is known about interorgan crosstalk, which we define as signaling between tissues by secreted factors. Besides hormones and organokines, dysregulated blood glucose and long-lasting hyperglycemia in T2D is associated with changes in metabolism with metabolites from different tissues contributing to the development of this disease. Recent data suggest that metabolites, such as lipids including free fatty acids and amino acids, play important roles in the interorgan crosstalk during the development of T2D. In general, metabolic remodeling affects physiological homeostasis and impacts the development of T2D. Hence, we highlight the importance of metabolic interorgan crosstalk in this review to gain enhanced knowledge of the pathophysiology of T2D, which may lead to new therapeutic approaches to treat this disease.
(Less)
- author
- Sanches, Jose Marcos
LU
; Zhao, Li Na
; Salehi, Albert
LU
; Wollheim, Claes B
LU
and Kaldis, Philipp
LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The FEBS Journal
- volume
- 290
- issue
- 3
- pages
- 620 - 648
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:34847289
- scopus:85120795508
- ISSN
- 1742-464X
- DOI
- 10.1111/febs.16306
- language
- English
- LU publication?
- yes
- additional info
- © 2021 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
- id
- feddb766-36a5-4628-bd51-ddd26aa7d728
- date added to LUP
- 2022-01-10 09:18:46
- date last changed
- 2024-06-15 23:44:12
@article{feddb766-36a5-4628-bd51-ddd26aa7d728,
abstract = {{<p>Diabetes is a complex and multifactorial disease that affects millions of people worldwide, reducing the quality of life significantly, and results in grave consequences for our health care system. In type 2 diabetes (T2D), the lack of β-cell compensatory mechanisms overcoming peripherally developed insulin resistance is a paramount factor leading to disturbed blood glucose levels and lipid metabolism. Impaired β-cell functions and insulin resistance have been studied extensively resulting in a good understanding of these pathways but much less is known about interorgan crosstalk, which we define as signaling between tissues by secreted factors. Besides hormones and organokines, dysregulated blood glucose and long-lasting hyperglycemia in T2D is associated with changes in metabolism with metabolites from different tissues contributing to the development of this disease. Recent data suggest that metabolites, such as lipids including free fatty acids and amino acids, play important roles in the interorgan crosstalk during the development of T2D. In general, metabolic remodeling affects physiological homeostasis and impacts the development of T2D. Hence, we highlight the importance of metabolic interorgan crosstalk in this review to gain enhanced knowledge of the pathophysiology of T2D, which may lead to new therapeutic approaches to treat this disease.</p>}},
author = {{Sanches, Jose Marcos and Zhao, Li Na and Salehi, Albert and Wollheim, Claes B and Kaldis, Philipp}},
issn = {{1742-464X}},
language = {{eng}},
number = {{3}},
pages = {{620--648}},
publisher = {{Wiley-Blackwell}},
series = {{The FEBS Journal}},
title = {{Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk}},
url = {{http://dx.doi.org/10.1111/febs.16306}},
doi = {{10.1111/febs.16306}},
volume = {{290}},
year = {{2023}},
}