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Experimental models of traumatic brain injury : do we really need to build a better mousetrap?

Morales, D M; Marklund, N LU ; Lebold, D; Thompson, H J; Pitkanen, A; Maxwell, W L; Longhi, L; Laurer, H; Maegele, M and Neugebauer, E, et al. (2005) In Neuroscience 136(4). p.971-989
Abstract

Approximately 4000 human beings experience a traumatic brain injury each day in the United States ranging in severity from mild to fatal. Improvements in initial management, surgical treatment, and neurointensive care have resulted in a better prognosis for traumatic brain injury patients but, to date, there is no available pharmaceutical treatment with proven efficacy, and prevention is the major protective strategy. Many patients are left with disabling changes in cognition, motor function, and personality. Over the past two decades, a number of experimental laboratories have attempted to develop novel and innovative ways to replicate, in animal models, the different aspects of this heterogenous clinical paradigm to better understand... (More)

Approximately 4000 human beings experience a traumatic brain injury each day in the United States ranging in severity from mild to fatal. Improvements in initial management, surgical treatment, and neurointensive care have resulted in a better prognosis for traumatic brain injury patients but, to date, there is no available pharmaceutical treatment with proven efficacy, and prevention is the major protective strategy. Many patients are left with disabling changes in cognition, motor function, and personality. Over the past two decades, a number of experimental laboratories have attempted to develop novel and innovative ways to replicate, in animal models, the different aspects of this heterogenous clinical paradigm to better understand and treat patients after traumatic brain injury. Although several clinically-relevant but different experimental models have been developed to reproduce specific characteristics of human traumatic brain injury, its heterogeneity does not allow one single model to reproduce the entire spectrum of events that may occur. The use of these models has resulted in an increased understanding of the pathophysiology of traumatic brain injury, including changes in molecular and cellular pathways and neurobehavioral outcomes. This review provides an up-to-date and critical analysis of the existing models of traumatic brain injury with a view toward guiding and improving future research endeavors.

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publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Behavior, Animal, Brain Injuries, Disease Models, Animal, Humans, Mice, Journal Article, Review
in
Neuroscience
volume
136
issue
4
pages
971 - 989
publisher
Elsevier
external identifiers
  • scopus:29044447857
ISSN
0306-4522
DOI
10.1016/j.neuroscience.2005.08.030
language
English
LU publication?
no
id
ff09f6fb-7558-47f0-ab99-756ed70ea7f5
date added to LUP
2018-03-04 11:16:51
date last changed
2018-12-02 04:59:11
@article{ff09f6fb-7558-47f0-ab99-756ed70ea7f5,
  abstract     = {<p>Approximately 4000 human beings experience a traumatic brain injury each day in the United States ranging in severity from mild to fatal. Improvements in initial management, surgical treatment, and neurointensive care have resulted in a better prognosis for traumatic brain injury patients but, to date, there is no available pharmaceutical treatment with proven efficacy, and prevention is the major protective strategy. Many patients are left with disabling changes in cognition, motor function, and personality. Over the past two decades, a number of experimental laboratories have attempted to develop novel and innovative ways to replicate, in animal models, the different aspects of this heterogenous clinical paradigm to better understand and treat patients after traumatic brain injury. Although several clinically-relevant but different experimental models have been developed to reproduce specific characteristics of human traumatic brain injury, its heterogeneity does not allow one single model to reproduce the entire spectrum of events that may occur. The use of these models has resulted in an increased understanding of the pathophysiology of traumatic brain injury, including changes in molecular and cellular pathways and neurobehavioral outcomes. This review provides an up-to-date and critical analysis of the existing models of traumatic brain injury with a view toward guiding and improving future research endeavors.</p>},
  author       = {Morales, D M and Marklund, N and Lebold, D and Thompson, H J and Pitkanen, A and Maxwell, W L and Longhi, L and Laurer, H and Maegele, M and Neugebauer, E and Graham, D I and Stocchetti, N and McIntosh, T K},
  issn         = {0306-4522},
  keyword      = {Animals,Behavior, Animal,Brain Injuries,Disease Models, Animal,Humans,Mice,Journal Article,Review},
  language     = {eng},
  number       = {4},
  pages        = {971--989},
  publisher    = {Elsevier},
  series       = {Neuroscience},
  title        = {Experimental models of traumatic brain injury : do we really need to build a better mousetrap?},
  url          = {http://dx.doi.org/10.1016/j.neuroscience.2005.08.030},
  volume       = {136},
  year         = {2005},
}