The immunomodulatory quinoline-3-carboxamide paquinimod reverses established fibrosis in a novel mouse model for liver fibrosis
(2018) In PLoS ONE 13(9).- Abstract
- Quinoline-3-carboxamides (Q substances) are small molecule compounds with anti-inflammatory properties. In this study, we used one of these substances, Paquinimod, to treat a novel model for chronic liver inflammation and liver fibrosis, the NOD-Inflammation Fibrosis (N-IF) mouse. We show that treatment of N-IF mice significantly reduced inflammation and resulted in the regression of fibrosis, even when the treatment was initiated after onset of disease. The reduced disease phenotype was associated with a systemic decrease in the number and reduced activation of disease-promoting transgenic natural killer T (NKT)-II cells and their type 2-cytokine expression profile. Paquinimod treatment also led to a reduction of CD115+ Ly6Chi monocytes... (More)
- Quinoline-3-carboxamides (Q substances) are small molecule compounds with anti-inflammatory properties. In this study, we used one of these substances, Paquinimod, to treat a novel model for chronic liver inflammation and liver fibrosis, the NOD-Inflammation Fibrosis (N-IF) mouse. We show that treatment of N-IF mice significantly reduced inflammation and resulted in the regression of fibrosis, even when the treatment was initiated after onset of disease. The reduced disease phenotype was associated with a systemic decrease in the number and reduced activation of disease-promoting transgenic natural killer T (NKT)-II cells and their type 2-cytokine expression profile. Paquinimod treatment also led to a reduction of CD115+ Ly6Chi monocytes and CD11b+ F4/80+ CD206+ macrophages. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/ff8147bc-6d5f-4753-a118-c3c67454dc2e
- author
- Fransén Pettersson, Nina LU ; Deronic, Adnan LU ; Nilsson, Julia LU ; Hannibal, Tine LU ; Hansen, Lisbeth LU ; Schmidt-Christensen, Anja LU ; Ivars, Fredrik LU and Holmberg, Dan LU
- organization
- publishing date
- 2018-09-05
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 13
- issue
- 9
- article number
- e0203228
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- scopus:85052863945
- pmid:30183741
- pmid:30183741
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0203228
- project
- chronic Inflammation and fibrosis
- language
- English
- LU publication?
- yes
- id
- ff8147bc-6d5f-4753-a118-c3c67454dc2e
- date added to LUP
- 2018-09-18 11:08:50
- date last changed
- 2022-08-17 20:23:45
@article{ff8147bc-6d5f-4753-a118-c3c67454dc2e, abstract = {{Quinoline-3-carboxamides (Q substances) are small molecule compounds with anti-inflammatory properties. In this study, we used one of these substances, Paquinimod, to treat a novel model for chronic liver inflammation and liver fibrosis, the NOD-Inflammation Fibrosis (N-IF) mouse. We show that treatment of N-IF mice significantly reduced inflammation and resulted in the regression of fibrosis, even when the treatment was initiated after onset of disease. The reduced disease phenotype was associated with a systemic decrease in the number and reduced activation of disease-promoting transgenic natural killer T (NKT)-II cells and their type 2-cytokine expression profile. Paquinimod treatment also led to a reduction of CD115+ Ly6Chi monocytes and CD11b+ F4/80+ CD206+ macrophages.}}, author = {{Fransén Pettersson, Nina and Deronic, Adnan and Nilsson, Julia and Hannibal, Tine and Hansen, Lisbeth and Schmidt-Christensen, Anja and Ivars, Fredrik and Holmberg, Dan}}, issn = {{1932-6203}}, language = {{eng}}, month = {{09}}, number = {{9}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS ONE}}, title = {{The immunomodulatory quinoline-3-carboxamide paquinimod reverses established fibrosis in a novel mouse model for liver fibrosis}}, url = {{http://dx.doi.org/10.1371/journal.pone.0203228}}, doi = {{10.1371/journal.pone.0203228}}, volume = {{13}}, year = {{2018}}, }