Relation of QRS Voltage and Prolonged QTc Interval to One-Year Mortality
(2020) In American Journal of Cardiology 134. p.138-142- Abstract
The association between QRS voltage and QTc interval prolongation with mortality for up to 1 year after recording an ECG on patients attending emergency departments (EDs) was examined in a retrospective register-based observational study on 37,473 patients attending 2 Danish EDs. Of 37,473 patients who had an ECG performed on their first ED presentation 2,164 (5.8%) died within 30 days of presentation and 6,395 (17.1%) died within a year. Compared with survivors, patients who died had significantly longer QRS intervals and lower QRS voltages. A combined lead I and II QRS voltage <=1.4 mV was consistently associated with approximately twice the risk of mortality for up to at least 1 year after the ECG recording and this risk was not... (More)
The association between QRS voltage and QTc interval prolongation with mortality for up to 1 year after recording an ECG on patients attending emergency departments (EDs) was examined in a retrospective register-based observational study on 37,473 patients attending 2 Danish EDs. Of 37,473 patients who had an ECG performed on their first ED presentation 2,164 (5.8%) died within 30 days of presentation and 6,395 (17.1%) died within a year. Compared with survivors, patients who died had significantly longer QRS intervals and lower QRS voltages. A combined lead I and II QRS voltage <=1.4 mV was consistently associated with approximately twice the risk of mortality for up to at least 1 year after the ECG recording and this risk was not influenced by the length of the QTc interval. The increased mortality risk of a low QRS voltage remained even after adjustment for age, gender, Charlson co-morbidity index, and abnormal sodium and urea levels. In conclusion, low QRS voltage is a simple measurement that could potentially be used as an objective prognostic marker.
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- author
- Bogh, Søren Bie ; Kellett, John ; Ekelund, Ulf LU and Brabrand, Mikkel
- publishing date
- 2020-11-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Aged, Aged, 80 and over, Cause of Death, Cohort Studies, Denmark, Electrocardiography, Emergency Service, Hospital, Female, Humans, Kaplan-Meier Estimate, Long QT Syndrome/physiopathology, Male, Middle Aged, Mortality, Proportional Hazards Models, Retrospective Studies
- in
- American Journal of Cardiology
- volume
- 134
- pages
- 138 - 142
- publisher
- Excerpta Medica
- external identifiers
-
- scopus:85090299848
- pmid:32892990
- ISSN
- 1879-1913
- DOI
- 10.1016/j.amjcard.2020.08.008
- language
- English
- LU publication?
- no
- additional info
- Copyright © 2020 Elsevier Inc. All rights reserved.
- id
- ffc5ebc5-324a-490c-a487-a438b1c5caa2
- date added to LUP
- 2022-09-29 20:58:42
- date last changed
- 2024-04-05 17:29:24
@article{ffc5ebc5-324a-490c-a487-a438b1c5caa2, abstract = {{<p>The association between QRS voltage and QTc interval prolongation with mortality for up to 1 year after recording an ECG on patients attending emergency departments (EDs) was examined in a retrospective register-based observational study on 37,473 patients attending 2 Danish EDs. Of 37,473 patients who had an ECG performed on their first ED presentation 2,164 (5.8%) died within 30 days of presentation and 6,395 (17.1%) died within a year. Compared with survivors, patients who died had significantly longer QRS intervals and lower QRS voltages. A combined lead I and II QRS voltage <=1.4 mV was consistently associated with approximately twice the risk of mortality for up to at least 1 year after the ECG recording and this risk was not influenced by the length of the QTc interval. The increased mortality risk of a low QRS voltage remained even after adjustment for age, gender, Charlson co-morbidity index, and abnormal sodium and urea levels. In conclusion, low QRS voltage is a simple measurement that could potentially be used as an objective prognostic marker.</p>}}, author = {{Bogh, Søren Bie and Kellett, John and Ekelund, Ulf and Brabrand, Mikkel}}, issn = {{1879-1913}}, keywords = {{Aged; Aged, 80 and over; Cause of Death; Cohort Studies; Denmark; Electrocardiography; Emergency Service, Hospital; Female; Humans; Kaplan-Meier Estimate; Long QT Syndrome/physiopathology; Male; Middle Aged; Mortality; Proportional Hazards Models; Retrospective Studies}}, language = {{eng}}, month = {{11}}, pages = {{138--142}}, publisher = {{Excerpta Medica}}, series = {{American Journal of Cardiology}}, title = {{Relation of QRS Voltage and Prolonged QTc Interval to One-Year Mortality}}, url = {{http://dx.doi.org/10.1016/j.amjcard.2020.08.008}}, doi = {{10.1016/j.amjcard.2020.08.008}}, volume = {{134}}, year = {{2020}}, }