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Relation of QRS Voltage and Prolonged QTc Interval to One-Year Mortality

Bogh, Søren Bie ; Kellett, John ; Ekelund, Ulf LU orcid and Brabrand, Mikkel (2020) In American Journal of Cardiology 134. p.138-142
Abstract

The association between QRS voltage and QTc interval prolongation with mortality for up to 1 year after recording an ECG on patients attending emergency departments (EDs) was examined in a retrospective register-based observational study on 37,473 patients attending 2 Danish EDs. Of 37,473 patients who had an ECG performed on their first ED presentation 2,164 (5.8%) died within 30 days of presentation and 6,395 (17.1%) died within a year. Compared with survivors, patients who died had significantly longer QRS intervals and lower QRS voltages. A combined lead I and II QRS voltage <=1.4 mV was consistently associated with approximately twice the risk of mortality for up to at least 1 year after the ECG recording and this risk was not... (More)

The association between QRS voltage and QTc interval prolongation with mortality for up to 1 year after recording an ECG on patients attending emergency departments (EDs) was examined in a retrospective register-based observational study on 37,473 patients attending 2 Danish EDs. Of 37,473 patients who had an ECG performed on their first ED presentation 2,164 (5.8%) died within 30 days of presentation and 6,395 (17.1%) died within a year. Compared with survivors, patients who died had significantly longer QRS intervals and lower QRS voltages. A combined lead I and II QRS voltage <=1.4 mV was consistently associated with approximately twice the risk of mortality for up to at least 1 year after the ECG recording and this risk was not influenced by the length of the QTc interval. The increased mortality risk of a low QRS voltage remained even after adjustment for age, gender, Charlson co-morbidity index, and abnormal sodium and urea levels. In conclusion, low QRS voltage is a simple measurement that could potentially be used as an objective prognostic marker.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Aged, Aged, 80 and over, Cause of Death, Cohort Studies, Denmark, Electrocardiography, Emergency Service, Hospital, Female, Humans, Kaplan-Meier Estimate, Long QT Syndrome/physiopathology, Male, Middle Aged, Mortality, Proportional Hazards Models, Retrospective Studies
in
American Journal of Cardiology
volume
134
pages
138 - 142
publisher
Excerpta Medica
external identifiers
  • scopus:85090299848
  • pmid:32892990
ISSN
1879-1913
DOI
10.1016/j.amjcard.2020.08.008
language
English
LU publication?
no
additional info
Copyright © 2020 Elsevier Inc. All rights reserved.
id
ffc5ebc5-324a-490c-a487-a438b1c5caa2
date added to LUP
2022-09-29 20:58:42
date last changed
2024-04-05 17:29:24
@article{ffc5ebc5-324a-490c-a487-a438b1c5caa2,
  abstract     = {{<p>The association between QRS voltage and QTc interval prolongation with mortality for up to 1 year after recording an ECG on patients attending emergency departments (EDs) was examined in a retrospective register-based observational study on 37,473 patients attending 2 Danish EDs. Of 37,473 patients who had an ECG performed on their first ED presentation 2,164 (5.8%) died within 30 days of presentation and 6,395 (17.1%) died within a year. Compared with survivors, patients who died had significantly longer QRS intervals and lower QRS voltages. A combined lead I and II QRS voltage &lt;=1.4 mV was consistently associated with approximately twice the risk of mortality for up to at least 1 year after the ECG recording and this risk was not influenced by the length of the QTc interval. The increased mortality risk of a low QRS voltage remained even after adjustment for age, gender, Charlson co-morbidity index, and abnormal sodium and urea levels. In conclusion, low QRS voltage is a simple measurement that could potentially be used as an objective prognostic marker.</p>}},
  author       = {{Bogh, Søren Bie and Kellett, John and Ekelund, Ulf and Brabrand, Mikkel}},
  issn         = {{1879-1913}},
  keywords     = {{Aged; Aged, 80 and over; Cause of Death; Cohort Studies; Denmark; Electrocardiography; Emergency Service, Hospital; Female; Humans; Kaplan-Meier Estimate; Long QT Syndrome/physiopathology; Male; Middle Aged; Mortality; Proportional Hazards Models; Retrospective Studies}},
  language     = {{eng}},
  month        = {{11}},
  pages        = {{138--142}},
  publisher    = {{Excerpta Medica}},
  series       = {{American Journal of Cardiology}},
  title        = {{Relation of QRS Voltage and Prolonged QTc Interval to One-Year Mortality}},
  url          = {{http://dx.doi.org/10.1016/j.amjcard.2020.08.008}},
  doi          = {{10.1016/j.amjcard.2020.08.008}},
  volume       = {{134}},
  year         = {{2020}},
}