Congo red and protein aggregation in neurodegenerative diseases
(2007) In Brain Research Reviews 53(1). p.60-135- Abstract
Congo red is a commonly used histological dye for amyloid detection. The specificity of this staining results from Congo red's affinity for binding to fibril proteins enriched in beta-sheet conformation. Unexpectedly, recent investigations indicate that the dye also possesses the capacity to interfere with processes of protein misfolding and aggregation, stabilizing native protein monomers or partially folded intermediates, while reducing concentration of more toxic protein oligomers. Inhibitory effects of Congo red upon amyloid toxicity may also range from blockade of channel formation and interference with glycosaminoglycans binding or immune functions, to the modulation of gene expression. Particularly, Congo red exhibits... (More)
Congo red is a commonly used histological dye for amyloid detection. The specificity of this staining results from Congo red's affinity for binding to fibril proteins enriched in beta-sheet conformation. Unexpectedly, recent investigations indicate that the dye also possesses the capacity to interfere with processes of protein misfolding and aggregation, stabilizing native protein monomers or partially folded intermediates, while reducing concentration of more toxic protein oligomers. Inhibitory effects of Congo red upon amyloid toxicity may also range from blockade of channel formation and interference with glycosaminoglycans binding or immune functions, to the modulation of gene expression. Particularly, Congo red exhibits ameliorative effect in models of neurodegenerative disorders, such as Alzheimer's, Parkinson's, Huntington's and prion diseases. Another interesting application of Congo red analogues is the development of imaging probes. Based on their small molecular size and penetrability through blood-brain barrier, Congo red congeners can be used for both antemortem and in vivo visualization and quantification of brain amyloids. Therefore, understanding mechanisms involved in dye-amyloidal fibril binding and inhibition of aggregation will provide instructive guides for the design of future compounds, potentially useful for monitoring and treating neurodegenerative diseases.
(Less)
- author
- Frid, Petrea LU ; Anisimov, Sergey V LU and Popovic, Natalija LU
- organization
- publishing date
- 2007-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Amyloid beta-Peptides, Animals, Coloring Agents, Congo Red, Humans, Inclusion Bodies, Neurodegenerative Diseases, Neuroprotective Agents, Plaque, Amyloid, Protein Folding, Staining and Labeling, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review
- in
- Brain Research Reviews
- volume
- 53
- issue
- 1
- pages
- 26 pages
- publisher
- Elsevier
- external identifiers
-
- wos:000243221600009
- scopus:33845192482
- pmid:16959325
- ISSN
- 1872-6321
- DOI
- 10.1016/j.brainresrev.2006.08.001
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041), Basal Ganglia (013212026)
- id
- fff15997-7563-45d2-a678-4da54a57f243 (old id 161139)
- date added to LUP
- 2016-04-01 12:31:30
- date last changed
- 2022-04-21 08:38:13
@article{fff15997-7563-45d2-a678-4da54a57f243,
abstract = {{<p>Congo red is a commonly used histological dye for amyloid detection. The specificity of this staining results from Congo red's affinity for binding to fibril proteins enriched in beta-sheet conformation. Unexpectedly, recent investigations indicate that the dye also possesses the capacity to interfere with processes of protein misfolding and aggregation, stabilizing native protein monomers or partially folded intermediates, while reducing concentration of more toxic protein oligomers. Inhibitory effects of Congo red upon amyloid toxicity may also range from blockade of channel formation and interference with glycosaminoglycans binding or immune functions, to the modulation of gene expression. Particularly, Congo red exhibits ameliorative effect in models of neurodegenerative disorders, such as Alzheimer's, Parkinson's, Huntington's and prion diseases. Another interesting application of Congo red analogues is the development of imaging probes. Based on their small molecular size and penetrability through blood-brain barrier, Congo red congeners can be used for both antemortem and in vivo visualization and quantification of brain amyloids. Therefore, understanding mechanisms involved in dye-amyloidal fibril binding and inhibition of aggregation will provide instructive guides for the design of future compounds, potentially useful for monitoring and treating neurodegenerative diseases.</p>}},
author = {{Frid, Petrea and Anisimov, Sergey V and Popovic, Natalija}},
issn = {{1872-6321}},
keywords = {{Amyloid beta-Peptides; Animals; Coloring Agents; Congo Red; Humans; Inclusion Bodies; Neurodegenerative Diseases; Neuroprotective Agents; Plaque, Amyloid; Protein Folding; Staining and Labeling; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review}},
language = {{eng}},
number = {{1}},
pages = {{60--135}},
publisher = {{Elsevier}},
series = {{Brain Research Reviews}},
title = {{Congo red and protein aggregation in neurodegenerative diseases}},
url = {{http://dx.doi.org/10.1016/j.brainresrev.2006.08.001}},
doi = {{10.1016/j.brainresrev.2006.08.001}},
volume = {{53}},
year = {{2007}},
}