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On the molecular interactions in lipid bilayer-water assemblies of different curvatures

Talaikis, Martynas ; Valldeperas, Maria LU ; MatulaitieneÌ, Ieva ; Borzova, Jekaterina Latynis ; Barauskas, Justas LU ; Niaura, Gediminas and Nylander, Tommy LU (2019) In Journal of Physical Chemistry B 123(12). p.2662-2672
Abstract

This work concerns the importance of intermolecular interactions present in aqueous lipid assembly systems depending on the type of aggregates they form. We have studied aqueous mixtures of diglycerol monooleate, Capmul glycerol monoleate (GMO-50) and polyoxyethylene (20) sorbitan monooleate (Polysorbate 80, P80) using small-angle X-ray scattering (SAXS) measurements to reveal the structure of liquid crystalline phases. On the basis of the SAXS data, a phase diagram was constructed. We discuss the effect of curvature changes of the lipid-aqueous interface obtained by changing the water content and the temperature. The results are related to the intermolecular interactions, as revealed by Raman spectroscopy, with a focus on the bilayer... (More)

This work concerns the importance of intermolecular interactions present in aqueous lipid assembly systems depending on the type of aggregates they form. We have studied aqueous mixtures of diglycerol monooleate, Capmul glycerol monoleate (GMO-50) and polyoxyethylene (20) sorbitan monooleate (Polysorbate 80, P80) using small-angle X-ray scattering (SAXS) measurements to reveal the structure of liquid crystalline phases. On the basis of the SAXS data, a phase diagram was constructed. We discuss the effect of curvature changes of the lipid-aqueous interface obtained by changing the water content and the temperature. The results are related to the intermolecular interactions, as revealed by Raman spectroscopy, with a focus on the bilayer type of system of different curvature and bilayer flexibility, namely, the lamellar phase, bicontinuous cubic phase, and sponge phase. All phases show large similarities in their chain conformation and head group interactions as revealed by the Raman spectra, arising from the fact that all three structures are formed by lipid bilayers. However, subtle differences in the molecular organization of the sponge phase were revealed by employing Raman difference spectroscopy and by analysis of key spectroscopic indicators, which show a less dense hydrocarbon chain packing compared to the inverse bicontinuous cubic or lamellar phase.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Physical Chemistry B
volume
123
issue
12
pages
2662 - 2672
publisher
The American Chemical Society (ACS)
external identifiers
  • pmid:30785750
  • scopus:85063161018
ISSN
1520-6106
DOI
10.1021/acs.jpcb.8b11387
language
English
LU publication?
yes
id
fff2dabd-6519-40a7-8d02-5913430ebf14
date added to LUP
2019-04-02 14:53:06
date last changed
2024-04-30 03:41:33
@article{fff2dabd-6519-40a7-8d02-5913430ebf14,
  abstract     = {{<p>This work concerns the importance of intermolecular interactions present in aqueous lipid assembly systems depending on the type of aggregates they form. We have studied aqueous mixtures of diglycerol monooleate, Capmul glycerol monoleate (GMO-50) and polyoxyethylene (20) sorbitan monooleate (Polysorbate 80, P80) using small-angle X-ray scattering (SAXS) measurements to reveal the structure of liquid crystalline phases. On the basis of the SAXS data, a phase diagram was constructed. We discuss the effect of curvature changes of the lipid-aqueous interface obtained by changing the water content and the temperature. The results are related to the intermolecular interactions, as revealed by Raman spectroscopy, with a focus on the bilayer type of system of different curvature and bilayer flexibility, namely, the lamellar phase, bicontinuous cubic phase, and sponge phase. All phases show large similarities in their chain conformation and head group interactions as revealed by the Raman spectra, arising from the fact that all three structures are formed by lipid bilayers. However, subtle differences in the molecular organization of the sponge phase were revealed by employing Raman difference spectroscopy and by analysis of key spectroscopic indicators, which show a less dense hydrocarbon chain packing compared to the inverse bicontinuous cubic or lamellar phase.</p>}},
  author       = {{Talaikis, Martynas and Valldeperas, Maria and MatulaitieneÌ, Ieva and Borzova, Jekaterina Latynis and Barauskas, Justas and Niaura, Gediminas and Nylander, Tommy}},
  issn         = {{1520-6106}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{2662--2672}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Journal of Physical Chemistry B}},
  title        = {{On the molecular interactions in lipid bilayer-water assemblies of different curvatures}},
  url          = {{http://dx.doi.org/10.1021/acs.jpcb.8b11387}},
  doi          = {{10.1021/acs.jpcb.8b11387}},
  volume       = {{123}},
  year         = {{2019}},
}