Crystal Nucleation of Poorly Soluble Drugs : 2. Experimental results and new knowledge
(2011) KEMZ07 20111Department of Chemistry
- Abstract
- This report is a continuation of the report, Crystal nucleation of poorly soluble drugs, I Method development and initial results. [1]
The aim of the studies was to experimentally investigate the crystallization process. The focus has been on crystal growth, crystal dissolution and primary nucleation.
For three model substances, Bicalutamide, Linaprazan and Felodipine, experiments have been carried out. The experimental results have been compared to existing theoretical models to see how well the models can describe these processes.
For crystal growth and dissolution, a surface integration/disintegration constant, λ, can be used to try to describe the processes. The dissolution experiments could be well described by this model, while... (More) - This report is a continuation of the report, Crystal nucleation of poorly soluble drugs, I Method development and initial results. [1]
The aim of the studies was to experimentally investigate the crystallization process. The focus has been on crystal growth, crystal dissolution and primary nucleation.
For three model substances, Bicalutamide, Linaprazan and Felodipine, experiments have been carried out. The experimental results have been compared to existing theoretical models to see how well the models can describe these processes.
For crystal growth and dissolution, a surface integration/disintegration constant, λ, can be used to try to describe the processes. The dissolution experiments could be well described by this model, while growth could not. The model does however work better at high supersaturations than low ones, concerning growth.
The Hillig- Nielsen, polynuclear surface nucleation model was also used to evaluate the growth experiments. The model was able to describe the growth process better.
Obretenov interpolation, a model where both mono- and polynuclear growth are included, was also used to try to describe crystal growth. This model gave the best agreement between experimental results and theory so far.
Nucleation experiments were also conducted, and from the experiments the interfacial tension was to be determined. The development of this experimental method has been an important part of this work. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/student-papers/record/2861381
- author
- Franzén, Alexandra
- supervisor
- organization
- course
- KEMZ07 20111
- year
- 2011
- type
- H2 - Master's Degree (Two Years)
- subject
- keywords
- Fysikalisk kemi
- language
- English
- id
- 2861381
- date added to LUP
- 2012-07-06 15:14:01
- date last changed
- 2012-07-06 15:14:01
@misc{2861381, abstract = {{This report is a continuation of the report, Crystal nucleation of poorly soluble drugs, I Method development and initial results. [1] The aim of the studies was to experimentally investigate the crystallization process. The focus has been on crystal growth, crystal dissolution and primary nucleation. For three model substances, Bicalutamide, Linaprazan and Felodipine, experiments have been carried out. The experimental results have been compared to existing theoretical models to see how well the models can describe these processes. For crystal growth and dissolution, a surface integration/disintegration constant, λ, can be used to try to describe the processes. The dissolution experiments could be well described by this model, while growth could not. The model does however work better at high supersaturations than low ones, concerning growth. The Hillig- Nielsen, polynuclear surface nucleation model was also used to evaluate the growth experiments. The model was able to describe the growth process better. Obretenov interpolation, a model where both mono- and polynuclear growth are included, was also used to try to describe crystal growth. This model gave the best agreement between experimental results and theory so far. Nucleation experiments were also conducted, and from the experiments the interfacial tension was to be determined. The development of this experimental method has been an important part of this work.}}, author = {{Franzén, Alexandra}}, language = {{eng}}, note = {{Student Paper}}, title = {{Crystal Nucleation of Poorly Soluble Drugs : 2. Experimental results and new knowledge}}, year = {{2011}}, }