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Crystal Nucleation of Poorly Soluble Drugs : 2. Experimental results and new knowledge

Franzén, Alexandra (2011) KEMZ07 20111
Department of Chemistry
Abstract
This report is a continuation of the report, Crystal nucleation of poorly soluble drugs, I Method development and initial results. [1]
The aim of the studies was to experimentally investigate the crystallization process. The focus has been on crystal growth, crystal dissolution and primary nucleation.
For three model substances, Bicalutamide, Linaprazan and Felodipine, experiments have been carried out. The experimental results have been compared to existing theoretical models to see how well the models can describe these processes.
For crystal growth and dissolution, a surface integration/disintegration constant, λ, can be used to try to describe the processes. The dissolution experiments could be well described by this model, while... (More)
This report is a continuation of the report, Crystal nucleation of poorly soluble drugs, I Method development and initial results. [1]
The aim of the studies was to experimentally investigate the crystallization process. The focus has been on crystal growth, crystal dissolution and primary nucleation.
For three model substances, Bicalutamide, Linaprazan and Felodipine, experiments have been carried out. The experimental results have been compared to existing theoretical models to see how well the models can describe these processes.
For crystal growth and dissolution, a surface integration/disintegration constant, λ, can be used to try to describe the processes. The dissolution experiments could be well described by this model, while growth could not. The model does however work better at high supersaturations than low ones, concerning growth.
The Hillig- Nielsen, polynuclear surface nucleation model was also used to evaluate the growth experiments. The model was able to describe the growth process better.
Obretenov interpolation, a model where both mono- and polynuclear growth are included, was also used to try to describe crystal growth. This model gave the best agreement between experimental results and theory so far.
Nucleation experiments were also conducted, and from the experiments the interfacial tension was to be determined. The development of this experimental method has been an important part of this work. (Less)
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author
Franzén, Alexandra
supervisor
organization
course
KEMZ07 20111
year
type
H2 - Master's Degree (Two Years)
subject
keywords
Fysikalisk kemi
language
English
id
2861381
date added to LUP
2012-07-06 15:14:01
date last changed
2012-07-06 15:14:01
@misc{2861381,
  abstract     = {This report is a continuation of the report, Crystal nucleation of poorly soluble drugs, I Method development and initial results. [1]
The aim of the studies was to experimentally investigate the crystallization process. The focus has been on crystal growth, crystal dissolution and primary nucleation.
For three model substances, Bicalutamide, Linaprazan and Felodipine, experiments have been carried out. The experimental results have been compared to existing theoretical models to see how well the models can describe these processes.
For crystal growth and dissolution, a surface integration/disintegration constant, λ, can be used to try to describe the processes. The dissolution experiments could be well described by this model, while growth could not. The model does however work better at high supersaturations than low ones, concerning growth.
The Hillig- Nielsen, polynuclear surface nucleation model was also used to evaluate the growth experiments. The model was able to describe the growth process better.
Obretenov interpolation, a model where both mono- and polynuclear growth are included, was also used to try to describe crystal growth. This model gave the best agreement between experimental results and theory so far.
Nucleation experiments were also conducted, and from the experiments the interfacial tension was to be determined. The development of this experimental method has been an important part of this work.},
  author       = {Franzén, Alexandra},
  keyword      = {Fysikalisk kemi},
  language     = {eng},
  note         = {Student Paper},
  title        = {Crystal Nucleation of Poorly Soluble Drugs : 2. Experimental results and new knowledge},
  year         = {2011},
}