Advanced

Synthesis of 3-C-(4-aryl-5-halo-1,2,3-triazol-1-yl)-galactosides: Probing halogen bonding in galectin-ligand complexes

Ljungberg, Marcus LU (2011) KEMR11 20111
Department of Chemistry
Abstract
The continued search for compounds exhibiting a better inhibition of Galectin-3 and -1 has been performed in this thesis. It has been shown that the Galectins are over-expressed in cancer cells and play an important role in inflammatory conditions connected to apoptosis (cell death). The focus in this research project has been to explore if halogen-bonding, which gives a hydrogen-bond like character, can be used to improve the affinity for binding to the galectins. Activity was also found in synthesized monosaccharides but not nearly as good as previously tested disaccharides. But the results are a good foundation for future research on developing more drug candidates which are monosaccharides.
Please use this url to cite or link to this publication:
author
Ljungberg, Marcus LU
supervisor
organization
course
KEMR11 20111
year
type
H2 - Master's Degree (Two Years)
subject
keywords
Organisk kemi
language
English
id
2862859
date added to LUP
2012-08-14 14:12:06
date last changed
2012-08-14 14:12:06
@misc{2862859,
  abstract     = {The continued search for compounds exhibiting a better inhibition of Galectin-3 and -1 has been performed in this thesis. It has been shown that the Galectins are over-expressed in cancer cells and play an important role in inflammatory conditions connected to apoptosis (cell death). The focus in this research project has been to explore if halogen-bonding, which gives a hydrogen-bond like character, can be used to improve the affinity for binding to the galectins. Activity was also found in synthesized monosaccharides but not nearly as good as previously tested disaccharides. But the results are a good foundation for future research on developing more drug candidates which are monosaccharides.},
  author       = {Ljungberg, Marcus},
  keyword      = {Organisk kemi},
  language     = {eng},
  note         = {Student Paper},
  title        = {Synthesis of 3-C-(4-aryl-5-halo-1,2,3-triazol-1-yl)-galactosides: Probing halogen bonding in galectin-ligand complexes},
  year         = {2011},
}