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On the phase behavior of triglyceride/ethanol/water-systems

Thuresson, Sara LU (2017) KLG920 20162
Food Technology and Nutrition
Abstract
For personnel working in areas where hand disinfection is important, skin irritation on hands is a large and real problem. A solution may be a hand cream, containing ethanol, with moisturizing properties by using a Pickering emulsion. However, the effect of ethanol on a Pickering emulsion is unknown. The objective of this work was to gain understanding of this by mapping the phase diagram of triglyceride-ethanol-water, using tricaprin and triolein and 55-99.8% concentration of ethanol, mixed in ratios of 30:70, 50:50 and 70:30 (lipid:aqueous ethanol). The composition of the phases was then analyzed by high performance liquid chromatography (HPLC) and thermogravimetric analysis (TGA). The effect of ethanol on the melting point of the... (More)
For personnel working in areas where hand disinfection is important, skin irritation on hands is a large and real problem. A solution may be a hand cream, containing ethanol, with moisturizing properties by using a Pickering emulsion. However, the effect of ethanol on a Pickering emulsion is unknown. The objective of this work was to gain understanding of this by mapping the phase diagram of triglyceride-ethanol-water, using tricaprin and triolein and 55-99.8% concentration of ethanol, mixed in ratios of 30:70, 50:50 and 70:30 (lipid:aqueous ethanol). The composition of the phases was then analyzed by high performance liquid chromatography (HPLC) and thermogravimetric analysis (TGA). The effect of ethanol on the melting point of the triglyceride was examined by differential scanning calorimetry (DSC). In most samples, only a few percent triglyceride was found in the ethanol phase, but at 40°C and 99.8% ethanol, tricaprin and ethanol formed one single phase. The melting point was lowered slightly with increasing ethanol concentration. The results settle concerns that large amounts of oil dissolves into the continuous phase and disrupts the emulsion, and increase awareness of handling temperatures. Next steps would be investigating the properties of the Pickering emulsion and the antimicrobial effect of the ethanol when contained in a cream. (Less)
Popular Abstract (Swedish)
Många personers yrke kräver noggrann rengöring av händer flera gånger dagligen, och det är tydligt att huden tar stryk av detta. En mjukgörande kräm som samtidigt innehåller alkohol för att döda bakterierna hade varit en välkommen lösning för dessa personer. Men för att veta om
alkoholen kan påverka krämens stabilitet behöver man veta hur de separata komponenterna samspelar.
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author
Thuresson, Sara LU
supervisor
organization
course
KLG920 20162
year
type
H2 - Master's Degree (Two Years)
subject
keywords
Pharmaceutical technology, läkemedelsteknologi
language
English
id
8903543
date added to LUP
2017-02-24 12:22:17
date last changed
2017-02-24 12:22:17
@misc{8903543,
  abstract     = {For personnel working in areas where hand disinfection is important, skin irritation on hands is a large and real problem. A solution may be a hand cream, containing ethanol, with moisturizing properties by using a Pickering emulsion. However, the effect of ethanol on a Pickering emulsion is unknown. The objective of this work was to gain understanding of this by mapping the phase diagram of triglyceride-ethanol-water, using tricaprin and triolein and 55-99.8% concentration of ethanol, mixed in ratios of 30:70, 50:50 and 70:30 (lipid:aqueous ethanol). The composition of the phases was then analyzed by high performance liquid chromatography (HPLC) and thermogravimetric analysis (TGA). The effect of ethanol on the melting point of the triglyceride was examined by differential scanning calorimetry (DSC). In most samples, only a few percent triglyceride was found in the ethanol phase, but at 40°C and 99.8% ethanol, tricaprin and ethanol formed one single phase. The melting point was lowered slightly with increasing ethanol concentration. The results settle concerns that large amounts of oil dissolves into the continuous phase and disrupts the emulsion, and increase awareness of handling temperatures. Next steps would be investigating the properties of the Pickering emulsion and the antimicrobial effect of the ethanol when contained in a cream.},
  author       = {Thuresson, Sara},
  keyword      = {Pharmaceutical technology,läkemedelsteknologi},
  language     = {eng},
  note         = {Student Paper},
  title        = {On the phase behavior of triglyceride/ethanol/water-systems},
  year         = {2017},
}