Synthesis and characterization of Chromium complexes with pyridine-2-ylmethanimine ligand derivatives
(2024) KEMP20 20232Department of Chemistry
- Abstract
- The malaria parasite causes the deadly malaria disease that claims thousands of lives every year. While antimalarial drugs such as chloroquine and artemisinin exist, there is a continuous race to overcome the resistance developed by malaria parasites against drugs. Four new chromium complexes have been synthesized and characterized. The complexes contain quinoline structures with four different substituents at the 6- or 7-position with resemblance of quinoline part of the drug chloroquine. The complexation step was the coordination of the ligands with chromium hexacarbonyl to synthesize different metal complexes. All complexes have been characterized by 1H-NMR, UV-Vis, and FTIR spectroscopies.The malaria parasite causes the deadly malaria... (More)
- The malaria parasite causes the deadly malaria disease that claims thousands of lives every year. While antimalarial drugs such as chloroquine and artemisinin exist, there is a continuous race to overcome the resistance developed by malaria parasites against drugs. Four new chromium complexes have been synthesized and characterized. The complexes contain quinoline structures with four different substituents at the 6- or 7-position with resemblance of quinoline part of the drug chloroquine. The complexation step was the coordination of the ligands with chromium hexacarbonyl to synthesize different metal complexes. All complexes have been characterized by 1H-NMR, UV-Vis, and FTIR spectroscopies.The malaria parasite causes the deadly malaria disease that claims thousands of lives every year. While antimalarial drugs such as chloroquine and artemisinin exist, there is a continuous race to overcome the resistance developed by malaria parasites against drugs. Four new chromium complexes have been synthesized and characterized. The complexes contain quinoline structures with four different substituents at the 6- or 7-position with resemblance of quinoline part of the drug chloroquine. The complexation step was the coordination of the ligands with chromium hexacarbonyl to synthesize different metal complexes. All complexes have been characterized by 1H-NMR, UV-Vis, and FTIR spectroscopies. (Less)
- Popular Abstract
- Malaria is a deadly disease caused by malaria parasite. The parasite lives its life cycle between humans and mosquitoes. In 2022, the world health organization estimated that there were 249 million malaria cases and approximately 608 000 malaria deaths. This disease claims the lives of thousands of people every year. Scientists and researchers have been searching for treatments for this deadly disease since ancient times. One of the most important drugs discovered to treat malaria disease was chloroquine. Despite the effectivity of chloroquine, some of the malaria parasites have developed resistance to it.
In this study, four new compounds were synthesized to overcome this resistance. The new compounds were examined by different chemical... (More) - Malaria is a deadly disease caused by malaria parasite. The parasite lives its life cycle between humans and mosquitoes. In 2022, the world health organization estimated that there were 249 million malaria cases and approximately 608 000 malaria deaths. This disease claims the lives of thousands of people every year. Scientists and researchers have been searching for treatments for this deadly disease since ancient times. One of the most important drugs discovered to treat malaria disease was chloroquine. Despite the effectivity of chloroquine, some of the malaria parasites have developed resistance to it.
In this study, four new compounds were synthesized to overcome this resistance. The new compounds were examined by different chemical and physical methods to conform their structure. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/student-papers/record/9169251
- author
- Alsalehe, Ahmed Aadl LU
- supervisor
- organization
- course
- KEMP20 20232
- year
- 2024
- type
- H2 - Master's Degree (Two Years)
- subject
- keywords
- Inorganic chemistry, Anti malaria drug, Chromium complexes, Ligand synthesis, Organic chemistry
- language
- English
- id
- 9169251
- date added to LUP
- 2024-07-03 08:56:24
- date last changed
- 2024-07-03 08:58:24
@misc{9169251,
abstract = {{The malaria parasite causes the deadly malaria disease that claims thousands of lives every year. While antimalarial drugs such as chloroquine and artemisinin exist, there is a continuous race to overcome the resistance developed by malaria parasites against drugs. Four new chromium complexes have been synthesized and characterized. The complexes contain quinoline structures with four different substituents at the 6- or 7-position with resemblance of quinoline part of the drug chloroquine. The complexation step was the coordination of the ligands with chromium hexacarbonyl to synthesize different metal complexes. All complexes have been characterized by 1H-NMR, UV-Vis, and FTIR spectroscopies.The malaria parasite causes the deadly malaria disease that claims thousands of lives every year. While antimalarial drugs such as chloroquine and artemisinin exist, there is a continuous race to overcome the resistance developed by malaria parasites against drugs. Four new chromium complexes have been synthesized and characterized. The complexes contain quinoline structures with four different substituents at the 6- or 7-position with resemblance of quinoline part of the drug chloroquine. The complexation step was the coordination of the ligands with chromium hexacarbonyl to synthesize different metal complexes. All complexes have been characterized by 1H-NMR, UV-Vis, and FTIR spectroscopies.}},
author = {{Alsalehe, Ahmed Aadl}},
language = {{eng}},
note = {{Student Paper}},
title = {{Synthesis and characterization of Chromium complexes with pyridine-2-ylmethanimine ligand derivatives}},
year = {{2024}},
}