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Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease

Smith, Einar LU ; Ottosson, Filip LU ; Hellstrand, Sophie LU ; Ericson, Ulrika LU ; Orho-Melander, Marju LU ; Fernandez, Céline LU and Melander, Olle LU orcid (2019) In Heart
Abstract

Objectives: We recently identified a health conscious food pattern (HCFP) associated with reduced risk of cardiometabolic disease. However, the molecular events linking the healthy food pattern to reduced risk of cardiometabolic disease are unknown. Our aim was to identify plasma metabolites associated with the HCFP and test if such metabolites predict cardiometabolic disease and mortality. Methods: Using liquid-chromatography mass-spectrometry, 112 plasma metabolites were measured in 3236 participants without cardiovascular disease (CVD) and diabetes mellitus from the population-based Malmö Diet and Cancer study. Metabolites associated with the HCFP were identified using multivariable adjusted linear regressions followed by Bonferroni... (More)

Objectives: We recently identified a health conscious food pattern (HCFP) associated with reduced risk of cardiometabolic disease. However, the molecular events linking the healthy food pattern to reduced risk of cardiometabolic disease are unknown. Our aim was to identify plasma metabolites associated with the HCFP and test if such metabolites predict cardiometabolic disease and mortality. Methods: Using liquid-chromatography mass-spectrometry, 112 plasma metabolites were measured in 3236 participants without cardiovascular disease (CVD) and diabetes mellitus from the population-based Malmö Diet and Cancer study. Metabolites associated with the HCFP were identified using multivariable adjusted linear regressions followed by Bonferroni correction. The healthy dietary biomarkers were subsequently related to risk of cardiometabolic disease and mortality during long-term follow-up with multivariable adjusted Cox proportional hazards models. Results: During a median follow-up time of 21.4 years, 603 participants developed CVD, 362 developed diabetes mellitus and 843 participants died. Five healthy dietary biomarkers were associated with the HCFP at baseline (p<0.0004) and four predicted at least one of the studied end points (p<0.05). Ergothioneine was the metabolite most strongly connected to the HCFP and was associated with a lower risk of coronary disease (HR per 1 SD increment of ergothioneine, HR=0.85, p=0.01), cardiovascular mortality (HR=0.79, p=0.002) and overall mortality (HR=0.86, p=4e-5). Conclusions: We identified that higher ergothioneine was an independent marker of lower risk of cardiometabolic disease and mortality, which potentially can be induced by a specific healthy dietary intake.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Coronary artery disease, Epidemiology, Translational cardiovascular science
in
Heart
article number
315485
publisher
BMJ Publishing Group
external identifiers
  • pmid:31672783
  • scopus:85074471552
ISSN
1355-6037
DOI
10.1136/heartjnl-2019-315485
language
English
LU publication?
yes
id
07572165-6de0-49d4-b13a-6790b25d99ab
date added to LUP
2019-11-21 13:42:38
date last changed
2024-05-01 00:12:47
@article{07572165-6de0-49d4-b13a-6790b25d99ab,
  abstract     = {{<p>Objectives: We recently identified a health conscious food pattern (HCFP) associated with reduced risk of cardiometabolic disease. However, the molecular events linking the healthy food pattern to reduced risk of cardiometabolic disease are unknown. Our aim was to identify plasma metabolites associated with the HCFP and test if such metabolites predict cardiometabolic disease and mortality. Methods: Using liquid-chromatography mass-spectrometry, 112 plasma metabolites were measured in 3236 participants without cardiovascular disease (CVD) and diabetes mellitus from the population-based Malmö Diet and Cancer study. Metabolites associated with the HCFP were identified using multivariable adjusted linear regressions followed by Bonferroni correction. The healthy dietary biomarkers were subsequently related to risk of cardiometabolic disease and mortality during long-term follow-up with multivariable adjusted Cox proportional hazards models. Results: During a median follow-up time of 21.4 years, 603 participants developed CVD, 362 developed diabetes mellitus and 843 participants died. Five healthy dietary biomarkers were associated with the HCFP at baseline (p&lt;0.0004) and four predicted at least one of the studied end points (p&lt;0.05). Ergothioneine was the metabolite most strongly connected to the HCFP and was associated with a lower risk of coronary disease (HR per 1 SD increment of ergothioneine, HR=0.85, p=0.01), cardiovascular mortality (HR=0.79, p=0.002) and overall mortality (HR=0.86, p=4e-5). Conclusions: We identified that higher ergothioneine was an independent marker of lower risk of cardiometabolic disease and mortality, which potentially can be induced by a specific healthy dietary intake.</p>}},
  author       = {{Smith, Einar and Ottosson, Filip and Hellstrand, Sophie and Ericson, Ulrika and Orho-Melander, Marju and Fernandez, Céline and Melander, Olle}},
  issn         = {{1355-6037}},
  keywords     = {{Coronary artery disease; Epidemiology; Translational cardiovascular science}},
  language     = {{eng}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{Heart}},
  title        = {{Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease}},
  url          = {{http://dx.doi.org/10.1136/heartjnl-2019-315485}},
  doi          = {{10.1136/heartjnl-2019-315485}},
  year         = {{2019}},
}