Sequence Variation and Haplotype Structure Surrounding the Flowering Time Locus FRI in Arabidopsis thaliana.
(2002) In Genetics 161(1). p.289-298- Abstract
- Linkage disequilibrium in highly selfing organisms is expected to extend well beyond the scale of individual genes. The pattern of polymorphism in such species must thus be studied over a larger scale. We sequenced 14 short (0.5-1 kb) fragments from a 400-kb region surrounding the flowering time locus FRI in a sample of 20 accessions of Arabidopsis thaliana. The distribution of allele frequencies, as quantified by Tajima's D, varies considerably over the region and is incompatible with a standard neutral model. The region is characterized by extensive haplotype structure, with linkage disequilibrium decaying over 250 kb. In particular, recombination is evident within 35 kb of FRI in a haplotype associated with a functionally important... (More)
- Linkage disequilibrium in highly selfing organisms is expected to extend well beyond the scale of individual genes. The pattern of polymorphism in such species must thus be studied over a larger scale. We sequenced 14 short (0.5-1 kb) fragments from a 400-kb region surrounding the flowering time locus FRI in a sample of 20 accessions of Arabidopsis thaliana. The distribution of allele frequencies, as quantified by Tajima's D, varies considerably over the region and is incompatible with a standard neutral model. The region is characterized by extensive haplotype structure, with linkage disequilibrium decaying over 250 kb. In particular, recombination is evident within 35 kb of FRI in a haplotype associated with a functionally important allele. This suggests that A. thaliana may be highly suitable for linkage disequilibrium mapping. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/108295
- author
- Hagenblad, Jenny LU and Nordborg, Magnus
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Genetics
- volume
- 161
- issue
- 1
- pages
- 289 - 298
- publisher
- Genetics Society of America
- external identifiers
-
- pmid:12019242
- wos:000175814900025
- scopus:0036263045
- ISSN
- 0016-6731
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Genetics (Closed 2011) (011005100)
- id
- 715e9122-fb9c-44a8-9952-adddf5b601f9 (old id 108295)
- alternative location
- http://www.genetics.org/cgi/content/abstract/161/1/289
- date added to LUP
- 2016-04-01 11:45:59
- date last changed
- 2022-01-26 17:56:41
@article{715e9122-fb9c-44a8-9952-adddf5b601f9,
abstract = {{Linkage disequilibrium in highly selfing organisms is expected to extend well beyond the scale of individual genes. The pattern of polymorphism in such species must thus be studied over a larger scale. We sequenced 14 short (0.5-1 kb) fragments from a 400-kb region surrounding the flowering time locus FRI in a sample of 20 accessions of Arabidopsis thaliana. The distribution of allele frequencies, as quantified by Tajima's D, varies considerably over the region and is incompatible with a standard neutral model. The region is characterized by extensive haplotype structure, with linkage disequilibrium decaying over 250 kb. In particular, recombination is evident within 35 kb of FRI in a haplotype associated with a functionally important allele. This suggests that A. thaliana may be highly suitable for linkage disequilibrium mapping.}},
author = {{Hagenblad, Jenny and Nordborg, Magnus}},
issn = {{0016-6731}},
language = {{eng}},
number = {{1}},
pages = {{289--298}},
publisher = {{Genetics Society of America}},
series = {{Genetics}},
title = {{Sequence Variation and Haplotype Structure Surrounding the Flowering Time Locus FRI in Arabidopsis thaliana.}},
url = {{http://www.genetics.org/cgi/content/abstract/161/1/289}},
volume = {{161}},
year = {{2002}},
}