Increased autoantibodies to SOX13 in Swedish patients with type 1 diabetes.
(2002) In Annals of the New York Academy of Sciences 958. p.218-223- Abstract
- This article aims to estimate the prevalence of SOX13 antibodies in Swedish patients with type 1 diabetes and healthy controls. The patients (n = 102; median age 35 years [range, 9-89]) were newly diagnosed with type 1 diabetes in a defined area in southern Sweden during 1995-1998. Islet cell antibodies (ICA) were analyzed with immunofluorescence, while glutamic acid decarboxylase antibodies (GADA), tyrosine phosphatase antibodies (IA-2A), and antibodies against the transcription factor SOX13 (SOX13Ab) were analyzed with radioimmunoprecipitating assays. SOX13Ab were found in 9.8% (10/102) of type 1 patients compared to 2.0% (2/99) in healthy controls (P = 0.033). At least one of the four autoantibodies (ICA, GADA, IA-2A or SOX13Ab) were... (More)
- This article aims to estimate the prevalence of SOX13 antibodies in Swedish patients with type 1 diabetes and healthy controls. The patients (n = 102; median age 35 years [range, 9-89]) were newly diagnosed with type 1 diabetes in a defined area in southern Sweden during 1995-1998. Islet cell antibodies (ICA) were analyzed with immunofluorescence, while glutamic acid decarboxylase antibodies (GADA), tyrosine phosphatase antibodies (IA-2A), and antibodies against the transcription factor SOX13 (SOX13Ab) were analyzed with radioimmunoprecipitating assays. SOX13Ab were found in 9.8% (10/102) of type 1 patients compared to 2.0% (2/99) in healthy controls (P = 0.033). At least one of the four autoantibodies (ICA, GADA, IA-2A or SOX13Ab) were identified in 67% (68/102) of the patients. Samples positive for IA-2A were only in one case positive also for SOX13Ab. IA-2A-positive patients were often positive also for ICA and GADA (19/27), and the same combination was also common for SOX13Ab-positive patients (6/10). Only 2.0% (2/102) were positive for SOX13Ab alone. ICA, GADA and IA-2A were more frequent in younger patients (<or= 35 years of age) than in older patients, while SOX13Ab showed similar frequency in both groups. We concluded that the frequency of SOX13Ab was significantly increased in Swedish patients with type 1 diabetes, but that the addition of SOX13Ab to the combination of GADA and IA2-A only increased the sensitivity by 2% for autoimmune diabetes. Therefore, SOX13 could be a minor autoantigen involved in the pathogenesis of type 1 diabetes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/108329
- author
- Törn, Carina LU ; Shtauvere-Brameus, A ; Sanjeevi, C B and Landin-Olsson, Mona LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Diabetes Mellitus, Child, Autoantigens : immunology, Autoantigens : blood, Autoantibodies : immunology, Autoantibodies : blood, Aging : immunology, 80 and over, Aged, Adult, Adolescence, High Mobility Group Proteins : blood, High Mobility Group Proteins : immunology, Human, Middle Age, Support, Non-U.S. Gov't, Sweden : epidemiology, Insulin-Dependent : epidemiology, Insulin-Dependent : immunology
- in
- Annals of the New York Academy of Sciences
- volume
- 958
- pages
- 218 - 223
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000176952100034
- pmid:12021110
- scopus:0036271306
- ISSN
- 0077-8923
- DOI
- 10.1111/j.1749-6632.2002.tb02973
- language
- English
- LU publication?
- yes
- id
- b70deb06-52b3-4814-9a22-45a65523f17b (old id 108329)
- alternative location
- http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12021110&dopt=Abstract
- date added to LUP
- 2016-04-01 16:22:25
- date last changed
- 2024-01-11 06:50:32
@article{b70deb06-52b3-4814-9a22-45a65523f17b, abstract = {{This article aims to estimate the prevalence of SOX13 antibodies in Swedish patients with type 1 diabetes and healthy controls. The patients (n = 102; median age 35 years [range, 9-89]) were newly diagnosed with type 1 diabetes in a defined area in southern Sweden during 1995-1998. Islet cell antibodies (ICA) were analyzed with immunofluorescence, while glutamic acid decarboxylase antibodies (GADA), tyrosine phosphatase antibodies (IA-2A), and antibodies against the transcription factor SOX13 (SOX13Ab) were analyzed with radioimmunoprecipitating assays. SOX13Ab were found in 9.8% (10/102) of type 1 patients compared to 2.0% (2/99) in healthy controls (P = 0.033). At least one of the four autoantibodies (ICA, GADA, IA-2A or SOX13Ab) were identified in 67% (68/102) of the patients. Samples positive for IA-2A were only in one case positive also for SOX13Ab. IA-2A-positive patients were often positive also for ICA and GADA (19/27), and the same combination was also common for SOX13Ab-positive patients (6/10). Only 2.0% (2/102) were positive for SOX13Ab alone. ICA, GADA and IA-2A were more frequent in younger patients (<or= 35 years of age) than in older patients, while SOX13Ab showed similar frequency in both groups. We concluded that the frequency of SOX13Ab was significantly increased in Swedish patients with type 1 diabetes, but that the addition of SOX13Ab to the combination of GADA and IA2-A only increased the sensitivity by 2% for autoimmune diabetes. Therefore, SOX13 could be a minor autoantigen involved in the pathogenesis of type 1 diabetes.}}, author = {{Törn, Carina and Shtauvere-Brameus, A and Sanjeevi, C B and Landin-Olsson, Mona}}, issn = {{0077-8923}}, keywords = {{Diabetes Mellitus; Child; Autoantigens : immunology; Autoantigens : blood; Autoantibodies : immunology; Autoantibodies : blood; Aging : immunology; 80 and over; Aged; Adult; Adolescence; High Mobility Group Proteins : blood; High Mobility Group Proteins : immunology; Human; Middle Age; Support; Non-U.S. Gov't; Sweden : epidemiology; Insulin-Dependent : epidemiology; Insulin-Dependent : immunology}}, language = {{eng}}, pages = {{218--223}}, publisher = {{Wiley-Blackwell}}, series = {{Annals of the New York Academy of Sciences}}, title = {{Increased autoantibodies to SOX13 in Swedish patients with type 1 diabetes.}}, url = {{http://dx.doi.org/10.1111/j.1749-6632.2002.tb02973}}, doi = {{10.1111/j.1749-6632.2002.tb02973}}, volume = {{958}}, year = {{2002}}, }