Cellular DNA content and prognosis of high-grade soft tissue sarcoma: the Scandinavian Sarcoma Group experience
(1990) In Journal of Clinical Oncology 8(3). p.538-547- Abstract
- The nuclear DNA content of 148 high-grade soft tissue sarcomas of the extremities and trunk was determined by flow cytometry, using tumor material from paraffin-embedded tissue. The patients were part of a prospective randomized clinical trial on the efficacy of adjuvant single-agent chemotherapy with doxorubicin. Chemotherapy did not improve the metastasis-free survival (MFS). After a median follow-up time of 48 months (range, 2 to 97), a multivariate analysis of prognostic factors for developing metastatic disease was performed. DNA aneuploidy was found to be an independent prognostic risk factor in addition to histologic malignancy grade IV, intratumoral vascular invasion, tumor size over 10 cm, and male sex. Patients with none or one... (More)
- The nuclear DNA content of 148 high-grade soft tissue sarcomas of the extremities and trunk was determined by flow cytometry, using tumor material from paraffin-embedded tissue. The patients were part of a prospective randomized clinical trial on the efficacy of adjuvant single-agent chemotherapy with doxorubicin. Chemotherapy did not improve the metastasis-free survival (MFS). After a median follow-up time of 48 months (range, 2 to 97), a multivariate analysis of prognostic factors for developing metastatic disease was performed. DNA aneuploidy was found to be an independent prognostic risk factor in addition to histologic malignancy grade IV, intratumoral vascular invasion, tumor size over 10 cm, and male sex. Patients with none or one risk factor had a 5-year MFS of 79%, with two risk factors 65%, with three risk factors 43%, and with four and five risk factors 0%. About one half (78 of 148) of the patients with three factors or less belonged to a group with a MFS over 60%. The combination of different risk factors, including DNA aneuploidy, seems to be a useful prognostic model for soft tissue sarcomas, which could be of value to select high-risk patients for further trials with adjunctive therapy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1105018
- author
- Alvegård, Thor LU ; Berg, N O ; Baldetorp, Bo LU ; Fernö, Mårten LU ; Killander, Dick LU ; Ranstam, Jonas LU ; Rydholm, Anders LU and Åkerman, Måns LU
- organization
- publishing date
- 1990
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Clinical Oncology
- volume
- 8
- issue
- 3
- pages
- 538 - 547
- publisher
- American Society of Clinical Oncology
- external identifiers
-
- pmid:2407813
- scopus:0025265207
- ISSN
- 1527-7755
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Department of Orthopaedics (Lund) (013028000), Oncology, MV (013035000), Cancer Epidemiology (013007100)
- id
- 19ec10c2-6b0d-4c88-b9bb-866dd4f3e12e (old id 1105018)
- alternative location
- http://www.jco.ascopubs.org/cgi/reprint/8/3/538
- date added to LUP
- 2016-04-01 11:54:42
- date last changed
- 2021-08-29 05:37:51
@article{19ec10c2-6b0d-4c88-b9bb-866dd4f3e12e, abstract = {{The nuclear DNA content of 148 high-grade soft tissue sarcomas of the extremities and trunk was determined by flow cytometry, using tumor material from paraffin-embedded tissue. The patients were part of a prospective randomized clinical trial on the efficacy of adjuvant single-agent chemotherapy with doxorubicin. Chemotherapy did not improve the metastasis-free survival (MFS). After a median follow-up time of 48 months (range, 2 to 97), a multivariate analysis of prognostic factors for developing metastatic disease was performed. DNA aneuploidy was found to be an independent prognostic risk factor in addition to histologic malignancy grade IV, intratumoral vascular invasion, tumor size over 10 cm, and male sex. Patients with none or one risk factor had a 5-year MFS of 79%, with two risk factors 65%, with three risk factors 43%, and with four and five risk factors 0%. About one half (78 of 148) of the patients with three factors or less belonged to a group with a MFS over 60%. The combination of different risk factors, including DNA aneuploidy, seems to be a useful prognostic model for soft tissue sarcomas, which could be of value to select high-risk patients for further trials with adjunctive therapy.}}, author = {{Alvegård, Thor and Berg, N O and Baldetorp, Bo and Fernö, Mårten and Killander, Dick and Ranstam, Jonas and Rydholm, Anders and Åkerman, Måns}}, issn = {{1527-7755}}, language = {{eng}}, number = {{3}}, pages = {{538--547}}, publisher = {{American Society of Clinical Oncology}}, series = {{Journal of Clinical Oncology}}, title = {{Cellular DNA content and prognosis of high-grade soft tissue sarcoma: the Scandinavian Sarcoma Group experience}}, url = {{http://www.jco.ascopubs.org/cgi/reprint/8/3/538}}, volume = {{8}}, year = {{1990}}, }