Analysis of peripheral blood lymphocyte phenotype and function during dexamethazone treatment of progressive multiple sclerosis
(1991) In Acta Neurologica Scandinavica 84(2). p.91-97- Abstract
- Five patients with chronic progressive multiple sclerosis (MS) and three control patients with lumbar disc herniation were treated with dexamethazone during 14 days. The effect on peripheral blood T-cell subsets and on the proliferative response of peripheral blood mononuclear cells (PBMC) to pokeweed mitogen (PWM) and anti-mu antibody was analyzed. Before treatment, the proportion of CD3+ and CD4+ PBMC was similar in MS and control patients, but the proportion of CD8+ and DR+ PBMC was lower and the PBMC were less responsive to anti-mu stimulation in MS patients compared to controls. Steroid treatment induced reversible granulocytosis and lymphocytosis. CD3+ and CD4+ cells increased and DR+ cells decreased in MS patients but not in... (More)
- Five patients with chronic progressive multiple sclerosis (MS) and three control patients with lumbar disc herniation were treated with dexamethazone during 14 days. The effect on peripheral blood T-cell subsets and on the proliferative response of peripheral blood mononuclear cells (PBMC) to pokeweed mitogen (PWM) and anti-mu antibody was analyzed. Before treatment, the proportion of CD3+ and CD4+ PBMC was similar in MS and control patients, but the proportion of CD8+ and DR+ PBMC was lower and the PBMC were less responsive to anti-mu stimulation in MS patients compared to controls. Steroid treatment induced reversible granulocytosis and lymphocytosis. CD3+ and CD4+ cells increased and DR+ cells decreased in MS patients but not in controls. Proliferation of anti-mu stimulated PBMC increased in MS-patients during the two weeks of treatment, but decreased in controls. The enhancement in the MS patients of pre-existing immune abnormalities suggests that a cautious attitude is warranted in the use of steroid treatment in chronic progressive MS. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1105644
- author
- Salmaggi, A ; Baldetorp, Bo LU ; Milanese, C ; Nespolo, A ; Parma, R and Sandberg Wollheim, Magnhild LU
- organization
- publishing date
- 1991
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Neurologica Scandinavica
- volume
- 84
- issue
- 2
- pages
- 91 - 97
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:1835240
- scopus:0025908943
- ISSN
- 1600-0404
- language
- English
- LU publication?
- yes
- id
- 09f2886d-1159-457c-a704-a30d23b0e00d (old id 1105644)
- date added to LUP
- 2016-04-01 15:59:12
- date last changed
- 2021-01-03 09:02:30
@article{09f2886d-1159-457c-a704-a30d23b0e00d, abstract = {{Five patients with chronic progressive multiple sclerosis (MS) and three control patients with lumbar disc herniation were treated with dexamethazone during 14 days. The effect on peripheral blood T-cell subsets and on the proliferative response of peripheral blood mononuclear cells (PBMC) to pokeweed mitogen (PWM) and anti-mu antibody was analyzed. Before treatment, the proportion of CD3+ and CD4+ PBMC was similar in MS and control patients, but the proportion of CD8+ and DR+ PBMC was lower and the PBMC were less responsive to anti-mu stimulation in MS patients compared to controls. Steroid treatment induced reversible granulocytosis and lymphocytosis. CD3+ and CD4+ cells increased and DR+ cells decreased in MS patients but not in controls. Proliferation of anti-mu stimulated PBMC increased in MS-patients during the two weeks of treatment, but decreased in controls. The enhancement in the MS patients of pre-existing immune abnormalities suggests that a cautious attitude is warranted in the use of steroid treatment in chronic progressive MS.}}, author = {{Salmaggi, A and Baldetorp, Bo and Milanese, C and Nespolo, A and Parma, R and Sandberg Wollheim, Magnhild}}, issn = {{1600-0404}}, language = {{eng}}, number = {{2}}, pages = {{91--97}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Neurologica Scandinavica}}, title = {{Analysis of peripheral blood lymphocyte phenotype and function during dexamethazone treatment of progressive multiple sclerosis}}, volume = {{84}}, year = {{1991}}, }