An lrp-like gene of Bacillus subtilis involved in branched-chain amino acid transport
(1997) In Journal of Bacteriology 179(17). p.5448-5457- Abstract
- The azlB locus of Bacillus subtilis was defined previously by a mutation conferring resistance to a leucine analog, 4-azaleucine (J. B. Ward, Jr., and S. A. Zahler, J. Bacteriol. 116:727-735, 1973). In this report, azlB is shown to be the first gene of an operon apparently involved in branched-chain amino acid transport. The product of the azlB gene is an Lrp-like protein that negatively regulates expression of the azlBCDEF operon. Resistance to 4-azaleucine in azlB mutants is due to overproduction of AzlC and AzlD, two novel hydrophobic proteins.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1111908
- author
- Belitsky, B R ; Gustafsson, Mattias LU ; Sonenshein, A L and von Wachenfeldt, Claes LU
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Bacteriology
- volume
- 179
- issue
- 17
- pages
- 5448 - 5457
- publisher
- American Society for Microbiology
- external identifiers
-
- pmid:9287000
- scopus:0030885438
- ISSN
- 0021-9193
- language
- English
- LU publication?
- yes
- id
- 4e41ad28-a68a-44c9-88fe-3468160150e0 (old id 1111908)
- alternative location
- http://www.pubmedcentral.nih.gov/articlerender.fcgi?rendertype=abstract&artid=179416
- date added to LUP
- 2016-04-01 11:42:57
- date last changed
- 2024-05-07 12:24:18
@article{4e41ad28-a68a-44c9-88fe-3468160150e0, abstract = {{The azlB locus of Bacillus subtilis was defined previously by a mutation conferring resistance to a leucine analog, 4-azaleucine (J. B. Ward, Jr., and S. A. Zahler, J. Bacteriol. 116:727-735, 1973). In this report, azlB is shown to be the first gene of an operon apparently involved in branched-chain amino acid transport. The product of the azlB gene is an Lrp-like protein that negatively regulates expression of the azlBCDEF operon. Resistance to 4-azaleucine in azlB mutants is due to overproduction of AzlC and AzlD, two novel hydrophobic proteins.}}, author = {{Belitsky, B R and Gustafsson, Mattias and Sonenshein, A L and von Wachenfeldt, Claes}}, issn = {{0021-9193}}, language = {{eng}}, number = {{17}}, pages = {{5448--5457}}, publisher = {{American Society for Microbiology}}, series = {{Journal of Bacteriology}}, title = {{An lrp-like gene of Bacillus subtilis involved in branched-chain amino acid transport}}, url = {{http://www.pubmedcentral.nih.gov/articlerender.fcgi?rendertype=abstract&artid=179416}}, volume = {{179}}, year = {{1997}}, }