Persistent high signal on diffusion-weighted MRI in the late stages of small cortical and lacunar ischaemic lesions
(2001) In Neuroradiology 43(2). p.115-122- Abstract
- Diffusion-weighted imaging (DWI) is very sensitive to early brain infarcts. However, the late stages have been insufficiently studied. Infarcts in small vessel disease are often multiple and of different ages, and differentiation between new and old lesions might be difficult. We have therefore studied the change with time in DWI of small (< 3 ml) ischaemic lesions. We imaged 21 patients with an acute lacunar syndrome and a lesion visible on early DWI. They all had three MRI examinations 12-58 h (early), 7-16 and 54-144 days after the onset of stroke; 10 patients with high DWI signal on the third examination had a fourth examination 12-28 months after the stroke. MRI was performed at 1.5 T, using echo-planar DWI with 7 b-values from 0... (More)
- Diffusion-weighted imaging (DWI) is very sensitive to early brain infarcts. However, the late stages have been insufficiently studied. Infarcts in small vessel disease are often multiple and of different ages, and differentiation between new and old lesions might be difficult. We have therefore studied the change with time in DWI of small (< 3 ml) ischaemic lesions. We imaged 21 patients with an acute lacunar syndrome and a lesion visible on early DWI. They all had three MRI examinations 12-58 h (early), 7-16 and 54-144 days after the onset of stroke; 10 patients with high DWI signal on the third examination had a fourth examination 12-28 months after the stroke. MRI was performed at 1.5 T, using echo-planar DWI with 7 b-values from 0 to 1200 x 10(6) s/m2 and conventional T2-weighted imaging. After 7-16 days 18 of 21 lesions gave high signal on DWI, and 12/16 measurable lesions had a decreased apparent diffusion coefficient (ADC). After 54-144 days ten lesions still gave high DWI signal and two still had an ADC below normal. On the fourth examination there was no remaining high DWI signal and all ADC were higher than normal. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1121076
- author
- Geijer, Bo LU ; Lindgren, Arne LU ; Brockstedt, Sara LU ; Ståhlberg, Freddy LU and Holtås, Stig LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Key words Brain, ischaemia, Magnetic resonance imaging, diffusion-weighted
- in
- Neuroradiology
- volume
- 43
- issue
- 2
- pages
- 115 - 122
- publisher
- Springer
- external identifiers
-
- pmid:11326555
- scopus:0035131211
- ISSN
- 1432-1920
- DOI
- 10.1007/s002340000489
- language
- English
- LU publication?
- yes
- id
- c9627768-d829-4be5-b722-07cf8aaeb3ce (old id 1121076)
- date added to LUP
- 2016-04-01 11:39:13
- date last changed
- 2022-04-12 23:13:33
@article{c9627768-d829-4be5-b722-07cf8aaeb3ce, abstract = {{Diffusion-weighted imaging (DWI) is very sensitive to early brain infarcts. However, the late stages have been insufficiently studied. Infarcts in small vessel disease are often multiple and of different ages, and differentiation between new and old lesions might be difficult. We have therefore studied the change with time in DWI of small (< 3 ml) ischaemic lesions. We imaged 21 patients with an acute lacunar syndrome and a lesion visible on early DWI. They all had three MRI examinations 12-58 h (early), 7-16 and 54-144 days after the onset of stroke; 10 patients with high DWI signal on the third examination had a fourth examination 12-28 months after the stroke. MRI was performed at 1.5 T, using echo-planar DWI with 7 b-values from 0 to 1200 x 10(6) s/m2 and conventional T2-weighted imaging. After 7-16 days 18 of 21 lesions gave high signal on DWI, and 12/16 measurable lesions had a decreased apparent diffusion coefficient (ADC). After 54-144 days ten lesions still gave high DWI signal and two still had an ADC below normal. On the fourth examination there was no remaining high DWI signal and all ADC were higher than normal.}}, author = {{Geijer, Bo and Lindgren, Arne and Brockstedt, Sara and Ståhlberg, Freddy and Holtås, Stig}}, issn = {{1432-1920}}, keywords = {{Key words Brain; ischaemia; Magnetic resonance imaging; diffusion-weighted}}, language = {{eng}}, number = {{2}}, pages = {{115--122}}, publisher = {{Springer}}, series = {{Neuroradiology}}, title = {{Persistent high signal on diffusion-weighted MRI in the late stages of small cortical and lacunar ischaemic lesions}}, url = {{http://dx.doi.org/10.1007/s002340000489}}, doi = {{10.1007/s002340000489}}, volume = {{43}}, year = {{2001}}, }