Sd(a)-antigen-like structures carried on core 3 are prominent features of glycans from the mucin of normal human descending colon
(2001) In Biochemical Journal 358(Pt 3). p.657-664- Abstract
- This paper describes structural characterization by NMR, MS and degradative studies of mucin glycans from normal human descending colon obtained freshly at autopsy. The saccharides were mainly based on core 3 (GlcNAcbeta1-3GalNAc). Among the terminal saccharide determinants Sd(a)/Cad-antigen-like structures were prominent, and Lewis x, sialyl Lewis x and sulphated Lewis x were found as minor components, whereas blood group H and A antigenic determinants were absent. The saccharides were markedly different from those of mucins from colon cancers or colon cancer cell lines analysed so far, in which cores 1 and 2 are prominent features, and in which various other terminal determinants have been found, but not Sd(a)/Cad.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1123037
- author
- Capon, C ; Maes, E ; Michalski, J C ; Leffler, Hakon LU and Kim, Y S
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biochemical Journal
- volume
- 358
- issue
- Pt 3
- pages
- 657 - 664
- publisher
- Portland Press
- external identifiers
-
- pmid:11577689
- scopus:0035884645
- ISSN
- 0264-6021
- language
- English
- LU publication?
- yes
- id
- b1cf1790-2124-4794-9bcb-989c99afa760 (old id 1123037)
- date added to LUP
- 2016-04-01 16:30:40
- date last changed
- 2022-04-22 22:34:56
@article{b1cf1790-2124-4794-9bcb-989c99afa760, abstract = {{This paper describes structural characterization by NMR, MS and degradative studies of mucin glycans from normal human descending colon obtained freshly at autopsy. The saccharides were mainly based on core 3 (GlcNAcbeta1-3GalNAc). Among the terminal saccharide determinants Sd(a)/Cad-antigen-like structures were prominent, and Lewis x, sialyl Lewis x and sulphated Lewis x were found as minor components, whereas blood group H and A antigenic determinants were absent. The saccharides were markedly different from those of mucins from colon cancers or colon cancer cell lines analysed so far, in which cores 1 and 2 are prominent features, and in which various other terminal determinants have been found, but not Sd(a)/Cad.}}, author = {{Capon, C and Maes, E and Michalski, J C and Leffler, Hakon and Kim, Y S}}, issn = {{0264-6021}}, language = {{eng}}, number = {{Pt 3}}, pages = {{657--664}}, publisher = {{Portland Press}}, series = {{Biochemical Journal}}, title = {{Sd(a)-antigen-like structures carried on core 3 are prominent features of glycans from the mucin of normal human descending colon}}, volume = {{358}}, year = {{2001}}, }