Hakon Leffler

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2024
Mark Interplay of halogen bonding and solvation in protein-ligand binding
Verteramo, Maria Luisa ^LU ; Ignjatović, Majda Misini ; Kumar, Rohit ^LU ; Wernersson, Sven ^LU ; Ekberg, Vilhelm ^LU ; Wallerstein, Johan ^LU ; Carlström, Göran ^LU ; Chadimová, Veronika ; Leffler, Hakon ^LU and Zetterberg, Fredrik , et al. (2024) In iScience 27(4).
- Contribution to journal › Article
Mark Myocardin related transcription factor and galectin-3 drives lipid accumulation in human blood vessels
Arévalo-Martinez, Marycarmen ^LU ; Ede, Jacob ^LU ; van der Have, Oscar ^LU ; Ritsvall, Olivia ^LU ; Zetterberg, Fredrik R ; Nilsson, Ulf J ^LU ; Leffler, Hakon ^LU ; Holmberg, Johan ^LU and Albinsson, Sebastian ^LU (2024) In Vascular Pharmacology 156.
- Contribution to journal › Article
Mark Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer
Zetterberg, Fredrik R. ; Peterson, Kristoffer ; Nilsson, Ulf J. ^LU ; Andréasson Dahlgren, Kajsa ; Diehl, Carl ; Hoyler, Ian ; Håkansson, Maria ; Khabut, Areej ^LU ; Kahl-Knutson, Barbro ^LU and Leffler, Hakon ^LU , et al. (2024) In Journal of Medicinal Chemistry
- Contribution to journal › Article
Mark Endocytic Roles of Glycans on Proteins and Lipids
Johannes, Ludger ; Shafaq-Zadah, Massiullah ; Dransart, Estelle ; Wunder, Christian and Leffler, Hakon ^LU (2024) In Cold Spring Harbor perspectives in biology 16(1).
- Contribution to journal › Article
Mark Galectin-8N-Selective 4-Halophenylphthalazinone-Galactals Double π-Stack in a Unique Pocket
van Klaveren, Sjors ^LU ; Hassan, Mujtaba ^LU ; Håkansson, Maria ^LU ; Johnsson, Richard E. ^LU ; Larsson, Jessica ^LU ; Jakopin, Žiga ; Anderluh, Marko ^LU ; Leffler, Hakon ^LU ; Tomašič, Tihomir and Nilsson, Ulf J. ^LU (2024) In ACS Medicinal Chemistry Letters 15(8). p.1319-1324
- Contribution to journal › Article
2023
Mark Ligand Sulfur Oxidation State Progressively Alters Galectin-3-Ligand Complex Conformations To Induce Affinity-Influencing Hydrogen Bonds
Mahanti, Mukul ^LU ; Pal, Kumar Bhaskar ; Kumar, Rohit ^LU ; Schulze, Markus ; Leffler, Hakon ^LU ; Logan, Derek T ^LU and Nilsson, Ulf J ^LU (2023) In Journal of Medicinal Chemistry 66(21). p.14716-14723
- Contribution to journal › Article
Mark Galectin-1 induces a tumor-associated macrophage phenotype and upregulates indoleamine 2,3-dioxygenase-1
Rudjord-Levann, Asha M. ; Ye, Zilu ; Hafkenscheid, Lise ; Horn, Sabrina ; Wiegertjes, Renske ; Nielsen, Mathias A.I. ; Song, Ming ; Mathiesen, Caroline B.K. ; Stoop, Jesse and Stowell, Sean , et al. (2023) In iScience 26(7).
- Contribution to journal › Article
Mark Evaluating the affinity and kinetics of small molecule glycomimetics for human and mouse galectin-3 using surface plasmon resonance
Kim, Henry ; Weidner, Nathalie ; Ronin, Céline ; Klein, Emmanuel ; Roper, James A. ; Kahl-Knutson, Barbro ^LU ; Peterson, Kristoffer ^LU ; Leffler, Hakon ^LU ; Nilsson, Ulf J. ^LU and Pedersen, Anders , et al. (2023) In SLAS Discovery 28(5). p.233-239
- Contribution to journal › Article
Mark Novel inhibitory effect of galectin-3 on the respiratory burst induced by Staphylococcus aureus in human neutrophils
Venkatakrishnan, Vignesh ; Elmwall, Jonas ; Lahiri, Trisha ^LU ; Sundqvist, Martina ; Bergqvist, Linda ; Leffler, Hakon ^LU ; Nilsson, Ulf J ^LU ; Welin, Amanda ; Bylund, Johan and Karlsson-Bengtsson, Anna (2023) In Glycobiology 33(6). p.503-511
- Contribution to journal › Article
Mark Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor : a single- and multiple-dose first-in-human study in healthy participants
Aslanis, Vassilios ; Slack, Robert J. ; MacKinnon, Alison C. ; McClinton, Catherine ; Tantawi, Susan ; Gravelle, Lise ; Nilsson, Ulf J. ^LU ; Leffler, Hakon ^LU ; Brooks, Ashley and Khindri, Sanjeev K. , et al. (2023) In Cancer Chemotherapy and Pharmacology 91(3). p.267-280
- Contribution to journal › Article

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