Hakon Leffler

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2025
Mark Design, synthesis, and evaluation of a novel fluorescent probe for competitive fluorescence polarization assay to screen galectin-8 inhibitors
Purić, Edvin ; Marinović, Marina ; Kojek, Zala ; Kahl-Knutson, Barbro ^LU ; Leffler, Hakon ^LU ; Nilsson, Ulf J. ^LU ; Anderluh, Marko ^LU and Mravljak, Janez (2025) In Acta Pharmaceutica 75(2). p.273-282
- Contribution to journal › Article
Mark Nanomolar inhibitor of the galectin-8 N-terminal domain binds via a non-canonical cation-π interaction
Purić, Edvin ; Hassan, Mujtaba ^LU ; Sjövall, Fredrik ^LU ; Tomašič, Tihomir ; Pevec, Mojca ; Lah, Jurij ; Forteza, Jaume Adrover ^LU ; Sundin, Anders ^LU ; Leffler, Hakon ^LU and Nilsson, Ulf J. ^LU , et al. (2025) In Communications Chemistry 8(1).
- Contribution to journal › Article
Mark Growth factor-triggered de-sialylation controls glycolipid-lectin-driven endocytosis
MacDonald, Ewan ; Forrester, Alison ; Valades-Cruz, Cesar A. ; Madsen, Thomas D. ^LU ; Hetmanski, Joseph H.R. ; Dransart, Estelle ; Ng, Yeap ; Godbole, Rashmi ; Shp, Ananthan Akhil and Leconte, Ludovic , et al. (2025) In Nature Cell Biology 27(3). p.449-463
- Contribution to journal › Article
Mark Synergy of triazolyl substituents at C1 and C3 of galactose for high-affinity and selective galectin-4C inhibition
Dahlqvist, Alexander ^LU ; Go, Rob Marc ; Kishor, Chandan ; Leffler, Hakon ^LU ; Blanchard, Helen and Nilsson, Ulf J ^LU (2025) In RSC Chemical Biology 6(9). p.1437-1450
- Contribution to journal › Article
2024
Mark Endocytic Roles of Glycans on Proteins and Lipids
Johannes, Ludger ; Shafaq-Zadah, Massiullah ; Dransart, Estelle ; Wunder, Christian and Leffler, Hakon ^LU (2024) In Cold Spring Harbor perspectives in biology 16(1).
- Contribution to journal › Article
Mark Development and Characterization of a High-Affinity Selective Galectin-3 Mouse Tool Compound in Mouse Models of Cancer
Peterson, Kristoffer ^LU ; Nilsson, Ulf J. ^LU ; Gravelle, Lise ; Holyer, Ian ; Jansson, Karl ; Kahl-Knutson, Barbro ^LU ; Leffler, Hakon ^LU ; MacKinnon, Alison C. ; Roper, James A. and Slack, Robert J. , et al. (2024) In Journal of Medicinal Chemistry 67(24). p.21905-21915
- Contribution to journal › Article
Mark Effect of GB1107, a novel galectin-3 inhibitor on pro-fibrotic signalling in the liver
MacKinnon, Alison C. ; Humphries, Duncan C. ; Herman, Kimberley ; Roper, James A. ; Holyer, Ian ; Mabbitt, Joseph ; Mills, Ross ; Nilsson, Ulf J. ^LU ; Leffler, Hakon ^LU and Pedersen, Anders , et al. (2024) In European Journal of Pharmacology 985.
- Contribution to journal › Article
Mark Sulfonamide-derivatized galactosides selectively target an unexplored binding site in the galectin-9N-terminal domain
Mahanti, Mukul ^LU ; Gummesson, Sofi ; Sundin, Anders ^LU ; Leffler, Hakon ^LU ; Zetterberg, Fredrik and Nilsson, Ulf J ^LU (2024) In Bioorganic & Medicinal Chemistry 116.
- Contribution to journal › Article
Mark Interplay of halogen bonding and solvation in protein-ligand binding
Verteramo, Maria Luisa ^LU ; Ignjatović, Majda Misini ; Kumar, Rohit ^LU ; Wernersson, Sven ^LU ; Ekberg, Vilhelm ^LU ; Wallerstein, Johan ^LU ; Carlström, Göran ^LU ; Chadimová, Veronika ; Leffler, Hakon ^LU and Zetterberg, Fredrik , et al. (2024) In iScience 27(4).
- Contribution to journal › Article
Mark Myocardin related transcription factor and galectin-3 drives lipid accumulation in human blood vessels
Arévalo-Martinez, Marycarmen ^LU ; Ede, Jacob ^LU ; van der Have, Oscar ^LU ; Ritsvall, Olivia ^LU ; Zetterberg, Fredrik R ; Nilsson, Ulf J ^LU ; Leffler, Hakon ^LU ; Holmberg, Johan ^LU and Albinsson, Sebastian ^LU (2024) In Vascular Pharmacology 156.
- Contribution to journal › Article

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