Hakon Leffler

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2023
Mark Increased synovial galectin-3 induce inflammatory fibroblast activation and osteoclastogenesis in patients with rheumatoid arthritis
Nielsen, M. A. ; Køster, D. ; Greisen, S. ; Troldborg, A. ; Stengaard-Pedersen, K. ; Junker, P. ; Hørslev-Petersen, K. ; Hetland, M. L. ; Østergaard, M. and Hvid, M. , et al. (2023) In Scandinavian Journal of Rheumatology 52(1). p.33-41
- Contribution to journal › Article
Mark Increased Galectin-9 Levels Correlate with Disease Activity in Patients with DMARD-Naïve Rheumatoid Arthritis and Modulate the Secretion of MCP-1 and IL-6 from Synovial Fibroblasts
Nielsen, Morten A. ; Køster, Ditte ; Mehta, Akul Y. ; Stengaard-Pedersen, Kristian ; Busson, Pierre ; Junker, Peter ; Hørslev-Petersen, Kim ; Hetland, Merete Lund ; Østergaard, Mikkel and Hvid, Malene , et al. (2023) In Cells 12(2).
- Contribution to journal › Article
Mark Evaluating the affinity and kinetics of small molecule glycomimetics for human and mouse galectin-3 using surface plasmon resonance
Kim, Henry ; Weidner, Nathalie ; Ronin, Céline ; Klein, Emmanuel ; Roper, James A. ; Kahl-Knutson, Barbro ^LU ; Peterson, Kristoffer ^LU ; Leffler, Hakon ^LU ; Nilsson, Ulf J. ^LU and Pedersen, Anders , et al. (2023) In SLAS Discovery
- Contribution to journal › Article
Mark Novel inhibitory effect of galectin-3 on the respiratory burst induced by Staphylococcus aureus in human neutrophils
Venkatakrishnan, Vignesh ; Elmwall, Jonas ; Lahiri, Trisha ^LU ; Sundqvist, Martina ; Bergqvist, Linda ; Leffler, Hakon ^LU ; Nilsson, Ulf J ^LU ; Welin, Amanda ; Bylund, Johan and Karlsson-Bengtsson, Anna (2023) In Glycobiology
- Contribution to journal › Article
Mark Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor : a single- and multiple-dose first-in-human study in healthy participants
Aslanis, Vassilios ; Slack, Robert J. ; MacKinnon, Alison C. ; McClinton, Catherine ; Tantawi, Susan ; Gravelle, Lise ; Nilsson, Ulf J. ^LU ; Leffler, Hakon ^LU ; Brooks, Ashley and Khindri, Sanjeev K. , et al. (2023) In Cancer Chemotherapy and Pharmacology 91(3). p.267-280
- Contribution to journal › Article
2022
Mark Selective Monovalent Galectin-8 Ligands Based on 3-Lactoylgalactoside
Girardi, Benedetta ; Manna, Martina ; Van Klaveren, Sjors ^LU ; Tomašič, Tihomir ; Jakopin, Žiga ; Leffler, Hakon ^LU ; Nilsson, Ulf J. ^LU ; Ricklin, Daniel ; Mravljak, Janez and Schwardt, Oliver , et al. (2022) In ChemMedChem 17(3).
- Contribution to journal › Article
Mark Installation of O-glycan sulfation capacities in human HEK293 cells for display of sulfated mucins
Sun, Lingbo ; Konstantinidi, Andriana ; Ye, Zilu ; Nason, Rebecca ; Zhang, Yuecheng ; Büll, Christian ; Kahl-Knutson, Barbro ^LU ; Hansen, Lars ; Leffler, Hakon ^LU and Vakhrushev, Sergey Y. , et al. (2022) In Journal of Biological Chemistry 298(2).
- Contribution to journal › Article
Mark Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease
Zetterberg, Fredrik R. ; Mackinnon, Alison ; Brimert, Thomas ; Gravelle, Lise ; Johnsson, Richard E. ; Kahl-Knutson, Barbro ^LU ; Leffler, Hakon ^LU ; Nilsson, Ulf J. ^LU ; Pedersen, Anders and Peterson, Kristoffer ^LU , et al. (2022) In Journal of Medicinal Chemistry 65(19). p.12626-12638
- Contribution to journal › Article
Mark Galectin-3 inhibitor GB0139 protects against acute lung injury by inhibiting neutrophil recruitment and activation
Humphries, Duncan C. ; Mills, Ross ; Boz, Cecilia ; McHugh, Brian J. ; Hirani, Nikhil ; Rossi, Adriano G. ; Pedersen, Anders ; Schambye, Hans T. ; Slack, Robert J. and Leffler, Hakon ^LU , et al. (2022) In Frontiers in Pharmacology 13.
- Contribution to journal › Article
Mark Engineering the Ligand Specificity of the Human Galectin-1 by Incorporation of Tryptophan Analogues
Tobola, Felix ; Lepšík, Martin ; Zia, Syeda Rehana ; Leffler, Hakon ^LU ; Nilsson, Ulf J. ^LU ; Blixt, Ola ; Imberty, Anne and Wiltschi, Birgit (2022) In ChemBioChem 23(5).
- Contribution to journal › Article

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