Hakon Leffler

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2025
Mark Nanomolar inhibitor of the galectin-8 N-terminal domain binds via a non-canonical cation-π interaction
Purić, Edvin ; Hassan, Mujtaba ^LU ; Sjövall, Fredrik ^LU ; Tomašič, Tihomir ; Pevec, Mojca ; Lah, Jurij ; Forteza, Jaume Adrover ^LU ; Sundin, Anders ^LU ; Leffler, Hakon ^LU and Nilsson, Ulf J. ^LU , et al. (2025) In Communications Chemistry 8(1).
- Contribution to journal › Article
Mark Design, synthesis, and evaluation of a novel fluorescent probe for competitive fluorescence polarization assay to screen galectin-8 inhibitors
Purić, Edvin ; Marinović, Marina ; Kojek, Zala ; Kahl-Knutson, Barbro ^LU ; Leffler, Hakon ^LU ; Nilsson, Ulf J. ^LU ; Anderluh, Marko ^LU and Mravljak, Janez (2025) In Acta Pharmaceutica
- Contribution to journal › Article
2024
Mark Endocytic Roles of Glycans on Proteins and Lipids
Johannes, Ludger ; Shafaq-Zadah, Massiullah ; Dransart, Estelle ; Wunder, Christian and Leffler, Hakon ^LU (2024) In Cold Spring Harbor perspectives in biology 16(1).
- Contribution to journal › Article
Mark Effect of GB1107, a novel galectin-3 inhibitor on pro-fibrotic signalling in the liver
MacKinnon, Alison C. ; Humphries, Duncan C. ; Herman, Kimberley ; Roper, James A. ; Holyer, Ian ; Mabbitt, Joseph ; Mills, Ross ; Nilsson, Ulf J. ^LU ; Leffler, Hakon ^LU and Pedersen, Anders , et al. (2024) In European Journal of Pharmacology 985.
- Contribution to journal › Article
Mark Development and Characterization of a High-Affinity Selective Galectin-3 Mouse Tool Compound in Mouse Models of Cancer
Peterson, Kristoffer ^LU ; Nilsson, Ulf J. ^LU ; Gravelle, Lise ; Holyer, Ian ; Jansson, Karl ; Kahl-Knutson, Barbro ^LU ; Leffler, Hakon ^LU ; MacKinnon, Alison C. ; Roper, James A. and Slack, Robert J. , et al. (2024) In Journal of Medicinal Chemistry 67(24). p.21905-21915
- Contribution to journal › Article
Mark Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance
Kim, Henry ; Kretz, Louis ; Ronin, Céline ; Starck, Christina ; Roper, James A. ; Kahl-Knutson, Barbro ^LU ; Peterson, Kristoffer ^LU ; Leffler, Hakon ^LU ; Nilsson, Ulf J. ^LU and Pedersen, Anders , et al. (2024) In International Journal of Molecular Sciences 25(12).
- Contribution to journal › Article
Mark Elevated Galectin-3 levels in the tumor microenvironment of ovarian cancer – implication of ROS mediated suppression of NK cell antitumor response via tumor-associated neutrophils
Karlsson, Veronika ; Stål, Ebba ; Stoopendahl, Emma ; Ivarsson, Anton ; Leffler, Hakon ^LU ; Lycke, Maria ; Sundqvist, Martina ; Sundfeldt, Karin ; Christenson, Karin and Bernson, Elin (2024) In Frontiers in Immunology 15.
- Contribution to journal › Article
Mark Exploration into Galectin-3 Driven Endocytosis and Lattices
Shafaq-Zadah, Massiullah ; Dransart, Estelle ; Mani, Satish Kailasam ; Sampaio, Julio Lopes ; Bouidghaghen, Lydia ; Nilsson, Ulf J. ^LU ; Leffler, Hakon ^LU and Johannes, Ludger (2024) In Biomolecules 14(9).
- Contribution to journal › Article
Mark The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis
Comeglio, Paolo ; Guarnieri, Giulia ; Filippi, Sandra ; Cellai, Ilaria ; Acciai, Gabriele ; Holyer, Ian ; Zetterberg, Fredrik ; Leffler, Hakon ^LU ; Kahl-Knutson, Barbro ^LU and Sarchielli, Erica , et al. (2024) In Frontiers in Pharmacology 15.
- Contribution to journal › Article
Mark Interplay of halogen bonding and solvation in protein-ligand binding
Verteramo, Maria Luisa ^LU ; Ignjatović, Majda Misini ; Kumar, Rohit ^LU ; Wernersson, Sven ^LU ; Ekberg, Vilhelm ^LU ; Wallerstein, Johan ^LU ; Carlström, Göran ^LU ; Chadimová, Veronika ; Leffler, Hakon ^LU and Zetterberg, Fredrik , et al. (2024) In iScience 27(4).
- Contribution to journal › Article

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