Delayed umbilical cord clamping at birth has effects on arterial and venous blood gases and lactate concentrations
Wiberg, Nana LU
; Källén, Karin
LU
and Olofsson, Per
LU
(2008)
In BJOG: An International Journal of Obstetrics & Gynaecology
115(6).
p.697-703
- Abstract
- BJECTIVE: To estimate the influence of delayed umbilical cord clamping at birth on arterial and venous umbilical cord blood gases, bicarbonate (HCO3-), base excess (BE) and lactate in vigorous newborns. SETTING: University hospital. DESIGN: Prospective observational. SAMPLE: Vaginally delivered term newborns. MATERIAL AND METHODS: Umbilical cord arterial and venous blood was sampled repeatedly every 45 seconds (T(0)= time zero; T(45)= 45 seconds, T(90)= 90 seconds) until the cord pulsations spontaneously ceased in 66 vigorous singletons with cephalic vaginal delivery at 36-42 weeks. Longitudinal comparisons were performed with the Wilcoxon signed-ranks matched pairs test. Mixed effect models were used to describe the shape of the... (More)
- BJECTIVE: To estimate the influence of delayed umbilical cord clamping at birth on arterial and venous umbilical cord blood gases, bicarbonate (HCO3-), base excess (BE) and lactate in vigorous newborns. SETTING: University hospital. DESIGN: Prospective observational. SAMPLE: Vaginally delivered term newborns. MATERIAL AND METHODS: Umbilical cord arterial and venous blood was sampled repeatedly every 45 seconds (T(0)= time zero; T(45)= 45 seconds, T(90)= 90 seconds) until the cord pulsations spontaneously ceased in 66 vigorous singletons with cephalic vaginal delivery at 36-42 weeks. Longitudinal comparisons were performed with the Wilcoxon signed-ranks matched pairs test. Mixed effect models were used to describe the shape of the regression curves. MAIN OUTCOME MEASURES: Longitudinal changes of umbilical cord blood gases and lactate. RESULTS: In arterial cord blood, there were significant decreases of pH (7.24-7.21), HCO3- (18.9-18.1 mmol/l) and BE (-4.85 to -6.14 mmol/l), and significant increases of PaCO(2) (7.64-8.07 kPa), PO(2) (2.30-2.74 kPa) and lactate (5.3-5.9 mmol/l) from T(0) to T(90), with the most pronounced changes at T(0)-T(45). Similar changes occurred in venous blood pH (7.32-7.31), HCO3- (19.54-19.33 mmol/l), BE (-4.93 to -5.19 mmol/l), PaCO(2) (5.69-5.81 kPa) and lactate (5.0-5.3 mmol/l), although the changes were smaller and most pronounced at T(45)-T(90). No significant changes were observed in venous PO(2). CONCLUSION: Persistent cord pulsations and delayed cord clamping at birth result in significantly different measured values of cord blood acid-base parameters. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1146873
- author
- Wiberg, Nana
LU
; Källén, Karin
LU
and Olofsson, Per
LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BJOG: An International Journal of Obstetrics & Gynaecology
- volume
- 115
- issue
- 6
- pages
- 697 - 703
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000254856300004
- scopus:41949131040
- pmid:18410652
- ISSN
- 1471-0528
- DOI
- 10.1111/j.1471-0528.2008.01708.x
- language
- English
- LU publication?
- yes
- id
- 77fc728c-8358-488a-8470-d7ea8b3ef9e1 (old id 1146873)
- date added to LUP
- 2016-04-01 14:56:42
- date last changed
- 2022-03-22 02:41:38
@article{77fc728c-8358-488a-8470-d7ea8b3ef9e1,
abstract = {{BJECTIVE: To estimate the influence of delayed umbilical cord clamping at birth on arterial and venous umbilical cord blood gases, bicarbonate (HCO3-), base excess (BE) and lactate in vigorous newborns. SETTING: University hospital. DESIGN: Prospective observational. SAMPLE: Vaginally delivered term newborns. MATERIAL AND METHODS: Umbilical cord arterial and venous blood was sampled repeatedly every 45 seconds (T(0)= time zero; T(45)= 45 seconds, T(90)= 90 seconds) until the cord pulsations spontaneously ceased in 66 vigorous singletons with cephalic vaginal delivery at 36-42 weeks. Longitudinal comparisons were performed with the Wilcoxon signed-ranks matched pairs test. Mixed effect models were used to describe the shape of the regression curves. MAIN OUTCOME MEASURES: Longitudinal changes of umbilical cord blood gases and lactate. RESULTS: In arterial cord blood, there were significant decreases of pH (7.24-7.21), HCO3- (18.9-18.1 mmol/l) and BE (-4.85 to -6.14 mmol/l), and significant increases of PaCO(2) (7.64-8.07 kPa), PO(2) (2.30-2.74 kPa) and lactate (5.3-5.9 mmol/l) from T(0) to T(90), with the most pronounced changes at T(0)-T(45). Similar changes occurred in venous blood pH (7.32-7.31), HCO3- (19.54-19.33 mmol/l), BE (-4.93 to -5.19 mmol/l), PaCO(2) (5.69-5.81 kPa) and lactate (5.0-5.3 mmol/l), although the changes were smaller and most pronounced at T(45)-T(90). No significant changes were observed in venous PO(2). CONCLUSION: Persistent cord pulsations and delayed cord clamping at birth result in significantly different measured values of cord blood acid-base parameters.}},
author = {{Wiberg, Nana and Källén, Karin and Olofsson, Per}},
issn = {{1471-0528}},
language = {{eng}},
number = {{6}},
pages = {{697--703}},
publisher = {{Wiley-Blackwell}},
series = {{BJOG: An International Journal of Obstetrics & Gynaecology}},
title = {{Delayed umbilical cord clamping at birth has effects on arterial and venous blood gases and lactate concentrations}},
url = {{http://dx.doi.org/10.1111/j.1471-0528.2008.01708.x}},
doi = {{10.1111/j.1471-0528.2008.01708.x}},
volume = {{115}},
year = {{2008}},
}