Glycaemic control, disease duration and beta-cell function in patients with Type 2 diabetes in a Swedish community. Skaraborg Hypertension and Diabetes Project.
(2002) In Diabetic Medicine 19(2). p.125-129- Abstract
- AimsTo examine determinants for glycaemic control in primary care patients with Type 2 diabetes.
MethodsIn a community-based surveillance of primary care patients with Type 2 diabetes, 190 men and 186 women were consecutively identified and examined for cardiovascular risk factors. Insulin resistance and beta-cell function were estimated using homeostasis model assessment (HOMA). Good glycaemic control was defined as HbA1c < 6.5%.
ResultsFollowing adjustment for age and gender, HbA1c>= 6.5% was associated with duration of diabetes (10.6 vs. 6.4 years, P < 0.001), lower levels of serum insulin (6.3 vs. 8.0 mU/l, P = 0.012), higher serum triglyceride levels (2.0 vs. 1.7 mmol/l, P = 0.002) and... (More) - AimsTo examine determinants for glycaemic control in primary care patients with Type 2 diabetes.
MethodsIn a community-based surveillance of primary care patients with Type 2 diabetes, 190 men and 186 women were consecutively identified and examined for cardiovascular risk factors. Insulin resistance and beta-cell function were estimated using homeostasis model assessment (HOMA). Good glycaemic control was defined as HbA1c < 6.5%.
ResultsFollowing adjustment for age and gender, HbA1c>= 6.5% was associated with duration of diabetes (10.6 vs. 6.4 years, P < 0.001), lower levels of serum insulin (6.3 vs. 8.0 mU/l, P = 0.012), higher serum triglyceride levels (2.0 vs. 1.7 mmol/l, P = 0.002) and impairment of beta-cell function (HOMA index 19.5 vs. 45.8, P < 0.001). The association between HbA1c levels and duration remained with adjustment for age, gender, waist-hip ratio (WHR) and serum triglycerides (odds ratio (OR) for HbA1c>= 6.5% by 5 years diabetes duration = 1.7; 95% confidence interval (CI) 1.4-2.1) but was lost following additional adjustment for beta-cell function (OR for HbA1c>= 6.5% = 1.3; 95% CI 0.96-1.7). In a separate linear regression with beta-cell function as the dependent variable there was a significant association with HbA1c after adjustments for differences in age, gender, WHR, serum triglyceride levels and diabetes duration (P < 0.001).
ConclusionsIncreasing HbA1c by time was associated with declining beta-cell function. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/115541
- author
- Östgren, Carl Johan LU ; Lindblad, Ulf LU ; Ranstam, Jonas LU ; Melander, Arne LU and Råstam, Lennart LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Human, Glycosylated: analysis, Hemoglobin A, Female, Non-Insulin-Dependent: blood, Aged, 8 Age of Onset, Diabetes Mellitus, Blood Pressure, Blood Glucose: metabolism, Cardiovascular Diseases: epidemiology, Diabetic Angiopathies: epidemiology, Non-Insulin-Dependent: physiopathology, Triglycerides: blood, Sweden, Support, Non-U.S. Gov't, Risk Factors, Male, Insulin: secretion, Insulin: blood, Islets of Langerhans: secretion
- in
- Diabetic Medicine
- volume
- 19
- issue
- 2
- pages
- 125 - 129
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000174576300007
- pmid:11874428
- scopus:0036125347
- ISSN
- 1464-5491
- DOI
- 10.1046/j.1464-5491.2002.00661.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Psychiatry/Primary Care/Public Health (013240500), Community Medicine (013241810), Department of Orthopaedics (Lund) (013028000)
- id
- 2b97f49d-4357-41cf-b30e-d41e42849679 (old id 115541)
- date added to LUP
- 2016-04-01 16:34:02
- date last changed
- 2022-01-28 20:34:06
@article{2b97f49d-4357-41cf-b30e-d41e42849679,
abstract = {{AimsTo examine determinants for glycaemic control in primary care patients with Type 2 diabetes.<br/><br>
<br/><br>
MethodsIn a community-based surveillance of primary care patients with Type 2 diabetes, 190 men and 186 women were consecutively identified and examined for cardiovascular risk factors. Insulin resistance and beta-cell function were estimated using homeostasis model assessment (HOMA). Good glycaemic control was defined as HbA1c < 6.5%.<br/><br>
<br/><br>
ResultsFollowing adjustment for age and gender, HbA1c>= 6.5% was associated with duration of diabetes (10.6 vs. 6.4 years, P < 0.001), lower levels of serum insulin (6.3 vs. 8.0 mU/l, P = 0.012), higher serum triglyceride levels (2.0 vs. 1.7 mmol/l, P = 0.002) and impairment of beta-cell function (HOMA index 19.5 vs. 45.8, P < 0.001). The association between HbA1c levels and duration remained with adjustment for age, gender, waist-hip ratio (WHR) and serum triglycerides (odds ratio (OR) for HbA1c>= 6.5% by 5 years diabetes duration = 1.7; 95% confidence interval (CI) 1.4-2.1) but was lost following additional adjustment for beta-cell function (OR for HbA1c>= 6.5% = 1.3; 95% CI 0.96-1.7). In a separate linear regression with beta-cell function as the dependent variable there was a significant association with HbA1c after adjustments for differences in age, gender, WHR, serum triglyceride levels and diabetes duration (P < 0.001).<br/><br>
<br/><br>
ConclusionsIncreasing HbA1c by time was associated with declining beta-cell function.}},
author = {{Östgren, Carl Johan and Lindblad, Ulf and Ranstam, Jonas and Melander, Arne and Råstam, Lennart}},
issn = {{1464-5491}},
keywords = {{Human; Glycosylated: analysis; Hemoglobin A; Female; Non-Insulin-Dependent: blood; Aged; 8
Age of Onset; Diabetes Mellitus; Blood Pressure; Blood Glucose: metabolism; Cardiovascular Diseases: epidemiology; Diabetic Angiopathies: epidemiology; Non-Insulin-Dependent: physiopathology; Triglycerides: blood; Sweden; Support; Non-U.S. Gov't; Risk Factors; Male; Insulin: secretion; Insulin: blood; Islets of Langerhans: secretion}},
language = {{eng}},
number = {{2}},
pages = {{125--129}},
publisher = {{Wiley-Blackwell}},
series = {{Diabetic Medicine}},
title = {{Glycaemic control, disease duration and beta-cell function in patients with Type 2 diabetes in a Swedish community. Skaraborg Hypertension and Diabetes Project.}},
url = {{https://lup.lub.lu.se/search/files/4710865/623803.pdf}},
doi = {{10.1046/j.1464-5491.2002.00661.x}},
volume = {{19}},
year = {{2002}},
}