Assessment of biological prognostic factors provides clinically relevant information in patients with diffuse large B-cell lymphoma-a Nordic Lymphoma Group study.
(2004) In Annals of Hematology 83(7). p.414-419- Abstract
- The purpose of this study was to investigate the prognostic effects of four biological markers, BCL2, TP53, Ki-67, and P-glycoprotein, and their possible clinical relevance in addition to the international prognostic index (IPI) in diffuse large B-cell lymphoma (DLBCL). A total of 405 patients with aggressive lymphoma, stage II-IV, between 18 and 67 years, were randomized in a trial comparing CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with MACOP-B (methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin). Of these, 267 cases were classified as DLBCL, with adequate paraffin blocks available in 207 cases, enabling immunohistochemical assessment of the expression of BCL2, TP53,... (More)
- The purpose of this study was to investigate the prognostic effects of four biological markers, BCL2, TP53, Ki-67, and P-glycoprotein, and their possible clinical relevance in addition to the international prognostic index (IPI) in diffuse large B-cell lymphoma (DLBCL). A total of 405 patients with aggressive lymphoma, stage II-IV, between 18 and 67 years, were randomized in a trial comparing CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with MACOP-B (methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin). Of these, 267 cases were classified as DLBCL, with adequate paraffin blocks available in 207 cases, enabling immunohistochemical assessment of the expression of BCL2, TP53, P-glycoprotein, and Ki-67. In a multivariate analysis, stratified for IPI, high BCL2 expression (>10%) low (<60%) expression of Ki-67, and high TP53 protein expression (>75%) were shown to provide additional prognostic information with regard to overall or failure-free survival. We found no association between expression of P-glycoprotein and outcome. Assessment of BCL2 positivity might be introduced as part of the routine investigation in patients with DLBCL, but further studies are necessary to confirm the clinical relevance of Ki-67 and TP53 expression. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/122662
- author
- Jerkeman, Mats LU ; Anderson, Harald LU ; Dictor, Michael LU ; Kvaløy, S. ; Åkerman, Måns LU and Cavallin-Ståhl, Eva LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- p-glycoprotein, diffuse large B-cell lymphoma, proliferation, TP53, BCL2
- in
- Annals of Hematology
- volume
- 83
- issue
- 7
- pages
- 414 - 419
- publisher
- Springer
- external identifiers
-
- wos:000221733000002
- pmid:15085385
- scopus:3042776316
- pmid:15085385
- ISSN
- 1432-0584
- DOI
- 10.1007/s00277-004-0855-x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Cancer Epidemiology (013007100), Pathology, (Lund) (013030000), Oncology, MV (013035000)
- id
- 3f60a266-c424-47b6-b94e-4d6f4eeb6719 (old id 122662)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15085385&dopt=Abstract
- date added to LUP
- 2016-04-01 11:57:58
- date last changed
- 2022-04-28 22:39:37
@article{3f60a266-c424-47b6-b94e-4d6f4eeb6719, abstract = {{The purpose of this study was to investigate the prognostic effects of four biological markers, BCL2, TP53, Ki-67, and P-glycoprotein, and their possible clinical relevance in addition to the international prognostic index (IPI) in diffuse large B-cell lymphoma (DLBCL). A total of 405 patients with aggressive lymphoma, stage II-IV, between 18 and 67 years, were randomized in a trial comparing CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with MACOP-B (methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin). Of these, 267 cases were classified as DLBCL, with adequate paraffin blocks available in 207 cases, enabling immunohistochemical assessment of the expression of BCL2, TP53, P-glycoprotein, and Ki-67. In a multivariate analysis, stratified for IPI, high BCL2 expression (>10%) low (<60%) expression of Ki-67, and high TP53 protein expression (>75%) were shown to provide additional prognostic information with regard to overall or failure-free survival. We found no association between expression of P-glycoprotein and outcome. Assessment of BCL2 positivity might be introduced as part of the routine investigation in patients with DLBCL, but further studies are necessary to confirm the clinical relevance of Ki-67 and TP53 expression.}}, author = {{Jerkeman, Mats and Anderson, Harald and Dictor, Michael and Kvaløy, S. and Åkerman, Måns and Cavallin-Ståhl, Eva}}, issn = {{1432-0584}}, keywords = {{p-glycoprotein; diffuse large B-cell lymphoma; proliferation; TP53; BCL2}}, language = {{eng}}, number = {{7}}, pages = {{414--419}}, publisher = {{Springer}}, series = {{Annals of Hematology}}, title = {{Assessment of biological prognostic factors provides clinically relevant information in patients with diffuse large B-cell lymphoma-a Nordic Lymphoma Group study.}}, url = {{http://dx.doi.org/10.1007/s00277-004-0855-x}}, doi = {{10.1007/s00277-004-0855-x}}, volume = {{83}}, year = {{2004}}, }