No effects on myocardial ischaemia in patients with stable ischaemic heart disease after treatment with ramipril for 6 months
(2001) In Current Controlled Trials. Cardiovascular Medicine 2(2). p.99-105- Abstract
- Objective: To assess the effects of a 6-month angiotensin-converting enzyme (ACE) inhibitor intervention on myocardial ischaemia.Method: We randomized 389 patients with stable coronary artery disease to double-blind treatment with ramipril 5 mg/day (n = 133), ramipril 1.25 mg/day (n = 133), or placebo (n = 123). Forty-eight-hour ambulatory electrocardiography was performed at baseline, and after 1 and 6 months.Results: Relevant baseline variables were similar in all groups. Changes over 6 months in duration of 1 mm ST-segment depression (STD), total ischaemic burden and maximum STD did not differ significantly between the treatment groups. There was no difference in the frequency of adverse events between the groups.ConclusionACE inhibitor... (More)
- Objective: To assess the effects of a 6-month angiotensin-converting enzyme (ACE) inhibitor intervention on myocardial ischaemia.Method: We randomized 389 patients with stable coronary artery disease to double-blind treatment with ramipril 5 mg/day (n = 133), ramipril 1.25 mg/day (n = 133), or placebo (n = 123). Forty-eight-hour ambulatory electrocardiography was performed at baseline, and after 1 and 6 months.Results: Relevant baseline variables were similar in all groups. Changes over 6 months in duration of 1 mm ST-segment depression (STD), total ischaemic burden and maximum STD did not differ significantly between the treatment groups. There was no difference in the frequency of adverse events between the groups.ConclusionACE inhibitor treatment has little impact on incidence and severity of myocardial ischaemia in patients with stable ischaemic heart disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/131457
- author
- Willenheimer, Ronnie LU ; Juul-Möller, Steen LU ; Forslund, Lennart and Erhardt, Leif RW LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Current Controlled Trials. Cardiovascular Medicine
- volume
- 2
- issue
- 2
- pages
- 99 - 105
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000173941100005
- scopus:17744393850
- ISSN
- 1468-6694
- DOI
- 10.1186/cvm-2-2-099
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Cardiology (013242100), Emergency medicine/Medicine/Surgery (013240200), Cardiology Research Group (013242120)
- id
- 8d0924e3-0051-49e7-a3f6-5b7c97654c40 (old id 131457)
- alternative location
- http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=11806779&dopt=AbstractPlus
- date added to LUP
- 2016-04-01 16:23:32
- date last changed
- 2022-01-28 19:23:12
@article{8d0924e3-0051-49e7-a3f6-5b7c97654c40, abstract = {{Objective: To assess the effects of a 6-month angiotensin-converting enzyme (ACE) inhibitor intervention on myocardial ischaemia.Method: We randomized 389 patients with stable coronary artery disease to double-blind treatment with ramipril 5 mg/day (n = 133), ramipril 1.25 mg/day (n = 133), or placebo (n = 123). Forty-eight-hour ambulatory electrocardiography was performed at baseline, and after 1 and 6 months.Results: Relevant baseline variables were similar in all groups. Changes over 6 months in duration of 1 mm ST-segment depression (STD), total ischaemic burden and maximum STD did not differ significantly between the treatment groups. There was no difference in the frequency of adverse events between the groups.ConclusionACE inhibitor treatment has little impact on incidence and severity of myocardial ischaemia in patients with stable ischaemic heart disease.}}, author = {{Willenheimer, Ronnie and Juul-Möller, Steen and Forslund, Lennart and Erhardt, Leif RW}}, issn = {{1468-6694}}, language = {{eng}}, number = {{2}}, pages = {{99--105}}, publisher = {{BioMed Central (BMC)}}, series = {{Current Controlled Trials. Cardiovascular Medicine}}, title = {{No effects on myocardial ischaemia in patients with stable ischaemic heart disease after treatment with ramipril for 6 months}}, url = {{https://lup.lub.lu.se/search/files/4659211/624214.pdf}}, doi = {{10.1186/cvm-2-2-099}}, volume = {{2}}, year = {{2001}}, }