Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia.
(2006) In Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis 30(3). p.254-261- Abstract
- A critical cell cycle regulatory protein, cyclin A1, has been implicated in the development of acute myeloid leukemia (AML). Here, we have examined the expression and clinical significance of cyclin A1 in childhood acute lymphoblastic leukemia (ALL). Cyclin A1 was highly expressed in lymphoblastic leukemic cell lines and in 22 of 30 ALL patients (73%). Cyclin A1 expression correlated with patient age (P=0.006), but not with cytogenetic abnormalities. Patients with high levels of cyclin A1 had poorer event-free survival (57.9%) compared to patients with lower levels (75%). (c) 2005 Elsevier Ltd. All rights reserved.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/143450
- author
- Wigerup, Caroline LU ; Øra, Ingrid LU ; Brunhoff, Cecilia LU ; Anagnostaki, Lola ; Landberg, Göran LU and Persson, Jenny L LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cyclin A1, cyclin dependent kinase, event, acute lymphoblastic leukemia, free survival, cell cycle, disease characteristics
- in
- Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
- volume
- 30
- issue
- 3
- pages
- 254 - 261
- publisher
- Elsevier
- external identifiers
-
- pmid:16182364
- wos:000235039900002
- scopus:30144443209
- pmid:16182364
- ISSN
- 1873-5835
- DOI
- 10.1016/j.leukres.2005.07.010
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Paediatrics (Lund) (013002000), Pathology (Malmö) (013031000), Molecular Medicine (013031200)
- id
- d111a3d6-741e-43b4-a3a8-90921470271e (old id 143450)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16182364&dopt=Abstract
- date added to LUP
- 2016-04-01 11:43:52
- date last changed
- 2022-01-26 17:23:15
@article{d111a3d6-741e-43b4-a3a8-90921470271e, abstract = {{A critical cell cycle regulatory protein, cyclin A1, has been implicated in the development of acute myeloid leukemia (AML). Here, we have examined the expression and clinical significance of cyclin A1 in childhood acute lymphoblastic leukemia (ALL). Cyclin A1 was highly expressed in lymphoblastic leukemic cell lines and in 22 of 30 ALL patients (73%). Cyclin A1 expression correlated with patient age (P=0.006), but not with cytogenetic abnormalities. Patients with high levels of cyclin A1 had poorer event-free survival (57.9%) compared to patients with lower levels (75%). (c) 2005 Elsevier Ltd. All rights reserved.}}, author = {{Wigerup, Caroline and Øra, Ingrid and Brunhoff, Cecilia and Anagnostaki, Lola and Landberg, Göran and Persson, Jenny L}}, issn = {{1873-5835}}, keywords = {{cyclin A1; cyclin dependent kinase; event; acute lymphoblastic leukemia; free survival; cell cycle; disease characteristics}}, language = {{eng}}, number = {{3}}, pages = {{254--261}}, publisher = {{Elsevier}}, series = {{Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis}}, title = {{Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia.}}, url = {{http://dx.doi.org/10.1016/j.leukres.2005.07.010}}, doi = {{10.1016/j.leukres.2005.07.010}}, volume = {{30}}, year = {{2006}}, }