Experimental evidence for major histocompatibility complex-allele-specific resistance to a bacterial infection
(2002) In Royal Society of London. Proceedings B. Biological Sciences 269(1504). p.2029-2033- Abstract
- The extreme polymorphism found at some major histocompatibility complex (MHC) loci is believed to be maintained by balancing selection caused by infectious pathogens. Experimental support for this is inconclusive. We have studied the interaction between certain MHC alleles and the bacterium Aeromonas salmonicida, which causes the severe disease furunculosis, in Atlantic salmon (Salmo salar L.). We designed full-sibling broods consisting of combinations of homozygote and heterozygote genotypes with respect to resistance or susceptibility alleles. The juveniles were experimentally infected with A. salmonicida and their individual survival was monitored. By comparing full siblings carrying different MHC genotypes the effects on survival due... (More)
- The extreme polymorphism found at some major histocompatibility complex (MHC) loci is believed to be maintained by balancing selection caused by infectious pathogens. Experimental support for this is inconclusive. We have studied the interaction between certain MHC alleles and the bacterium Aeromonas salmonicida, which causes the severe disease furunculosis, in Atlantic salmon (Salmo salar L.). We designed full-sibling broods consisting of combinations of homozygote and heterozygote genotypes with respect to resistance or susceptibility alleles. The juveniles were experimentally infected with A. salmonicida and their individual survival was monitored. By comparing full siblings carrying different MHC genotypes the effects on survival due to other segregating genes were minimized. We show that a pathogen has the potential to cause very intense selection pressure on particular MHC alleles; the relative fitness difference between individuals carrying different MHC alleles was as high as 0.5. A co-dominant pattern of disease resistance/susceptibility was found, indicative of qualitative difference in the immune response between individuals carrying the high- and low-resistance alleles. Rather unexpectedly, survival was not higher among heterozygous individuals as compared with homozygous ones. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/145498
- author
- Lohm, Jakob LU ; Grahn, Mats LU ; Langefors, Åsa LU ; Andersen, O ; Storset, A and von Schantz, Torbjörn LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Royal Society of London. Proceedings B. Biological Sciences
- volume
- 269
- issue
- 1504
- pages
- 2029 - 2033
- publisher
- Royal Society Publishing
- external identifiers
-
- wos:000178593600009
- pmid:12396502
- scopus:41049095379
- ISSN
- 1471-2954
- DOI
- 10.1098/rspb.2002.2114
- language
- English
- LU publication?
- yes
- id
- 9bff40b2-3401-4a60-ad53-062f6f2df6b5 (old id 145498)
- date added to LUP
- 2016-04-01 11:53:01
- date last changed
- 2024-02-23 11:14:42
@article{9bff40b2-3401-4a60-ad53-062f6f2df6b5, abstract = {{The extreme polymorphism found at some major histocompatibility complex (MHC) loci is believed to be maintained by balancing selection caused by infectious pathogens. Experimental support for this is inconclusive. We have studied the interaction between certain MHC alleles and the bacterium Aeromonas salmonicida, which causes the severe disease furunculosis, in Atlantic salmon (Salmo salar L.). We designed full-sibling broods consisting of combinations of homozygote and heterozygote genotypes with respect to resistance or susceptibility alleles. The juveniles were experimentally infected with A. salmonicida and their individual survival was monitored. By comparing full siblings carrying different MHC genotypes the effects on survival due to other segregating genes were minimized. We show that a pathogen has the potential to cause very intense selection pressure on particular MHC alleles; the relative fitness difference between individuals carrying different MHC alleles was as high as 0.5. A co-dominant pattern of disease resistance/susceptibility was found, indicative of qualitative difference in the immune response between individuals carrying the high- and low-resistance alleles. Rather unexpectedly, survival was not higher among heterozygous individuals as compared with homozygous ones.}}, author = {{Lohm, Jakob and Grahn, Mats and Langefors, Åsa and Andersen, O and Storset, A and von Schantz, Torbjörn}}, issn = {{1471-2954}}, language = {{eng}}, number = {{1504}}, pages = {{2029--2033}}, publisher = {{Royal Society Publishing}}, series = {{Royal Society of London. Proceedings B. Biological Sciences}}, title = {{Experimental evidence for major histocompatibility complex-allele-specific resistance to a bacterial infection}}, url = {{https://lup.lub.lu.se/search/files/2686002/625053.pdf}}, doi = {{10.1098/rspb.2002.2114}}, volume = {{269}}, year = {{2002}}, }