Plasma concentrations of growth arrest specific protein 6 and the soluble form of its tyrosine kinase receptor Axl as markers of large abdominal aortic aneurysms.
(2010) In Clinical Biochemistry 43. p.110-114- Abstract
- OBJECTIVE: The tyrosine kinase receptor Axl is expressed in the vasculature and Gas6 is the ligand. The extracellular part of Axl (sAxl) can be found in circulation. The aim of this study was to determine plasma concentrations of Gas6 and sAxl in patients with abdominal aortic aneurysms (AAA) and to evaluate if Gas6 and sAxl can be used as biomarkers. DESIGN AND METHODS: Immunoassays for sAxl and Gas6 were used to investigate plasma from AAA patients. Patients with large (n=123) or small AAA (n=122) were compared with healthy controls (n=141). RESULTS: Gas6 correlated positively and sAxl correlated negatively with AAA size. As a consequence, the calculated Gas6/sAxl ratios correlated even better to AAA size. Forty percent of all patients... (More)
- OBJECTIVE: The tyrosine kinase receptor Axl is expressed in the vasculature and Gas6 is the ligand. The extracellular part of Axl (sAxl) can be found in circulation. The aim of this study was to determine plasma concentrations of Gas6 and sAxl in patients with abdominal aortic aneurysms (AAA) and to evaluate if Gas6 and sAxl can be used as biomarkers. DESIGN AND METHODS: Immunoassays for sAxl and Gas6 were used to investigate plasma from AAA patients. Patients with large (n=123) or small AAA (n=122) were compared with healthy controls (n=141). RESULTS: Gas6 correlated positively and sAxl correlated negatively with AAA size. As a consequence, the calculated Gas6/sAxl ratios correlated even better to AAA size. Forty percent of all patients with a large AAA had higher Gas6/sAxl ratio than any in the control group. DISCUSSION: The Gas6/Axl system might be involved in AAA pathogenesis, and the Gas6/sAxl ratio may be useful as a biomarker. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1469947
- author
- Ekman, Carl LU ; Flondell-Sité, Despina LU ; Gottsäter, Anders LU ; Lindblad, Bengt LU and Dahlbäck, Björn LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical Biochemistry
- volume
- 43
- pages
- 110 - 114
- publisher
- Elsevier
- external identifiers
-
- wos:000273514400016
- pmid:19660445
- scopus:73049088895
- ISSN
- 1873-2933
- DOI
- 10.1016/j.clinbiochem.2009.07.025
- language
- English
- LU publication?
- yes
- id
- f39f2724-2213-4176-805f-35bf63bb15a9 (old id 1469947)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19660445?dopt=Abstract
- date added to LUP
- 2016-04-04 07:07:43
- date last changed
- 2024-02-12 08:17:17
@article{f39f2724-2213-4176-805f-35bf63bb15a9,
abstract = {{OBJECTIVE: The tyrosine kinase receptor Axl is expressed in the vasculature and Gas6 is the ligand. The extracellular part of Axl (sAxl) can be found in circulation. The aim of this study was to determine plasma concentrations of Gas6 and sAxl in patients with abdominal aortic aneurysms (AAA) and to evaluate if Gas6 and sAxl can be used as biomarkers. DESIGN AND METHODS: Immunoassays for sAxl and Gas6 were used to investigate plasma from AAA patients. Patients with large (n=123) or small AAA (n=122) were compared with healthy controls (n=141). RESULTS: Gas6 correlated positively and sAxl correlated negatively with AAA size. As a consequence, the calculated Gas6/sAxl ratios correlated even better to AAA size. Forty percent of all patients with a large AAA had higher Gas6/sAxl ratio than any in the control group. DISCUSSION: The Gas6/Axl system might be involved in AAA pathogenesis, and the Gas6/sAxl ratio may be useful as a biomarker.}},
author = {{Ekman, Carl and Flondell-Sité, Despina and Gottsäter, Anders and Lindblad, Bengt and Dahlbäck, Björn}},
issn = {{1873-2933}},
language = {{eng}},
pages = {{110--114}},
publisher = {{Elsevier}},
series = {{Clinical Biochemistry}},
title = {{Plasma concentrations of growth arrest specific protein 6 and the soluble form of its tyrosine kinase receptor Axl as markers of large abdominal aortic aneurysms.}},
url = {{https://lup.lub.lu.se/search/files/5125421/1478654.pdf}},
doi = {{10.1016/j.clinbiochem.2009.07.025}},
volume = {{43}},
year = {{2010}},
}