Comparative sequence analysis of the non-protein-coding mitochondrial DNA of inbred rat strains.
(2009) In PLoS ONE 4(12).- Abstract
- The proper function of mammalian mitochondria necessitates a coordinated expression of both nuclear and mitochondrial genes, most likely due to the co-evolution of nuclear and mitochondrial genomes. The non-protein coding regions of mitochondrial DNA (mtDNA) including the D-loop, tRNA and rRNA genes form a major component of this regulated expression unit. Here we present comparative analyses of the non-protein-coding regions from 27 Rattus norvegicus mtDNA sequences. There were two variable positions in 12S rRNA, 20 in 16S rRNA, eight within the tRNA genes and 13 in the D-loop. Only one of the three neutrality tests used demonstrated statistically significant evidence for selection in 16S rRNA and tRNA-Cys. Based on our analyses of... (More)
- The proper function of mammalian mitochondria necessitates a coordinated expression of both nuclear and mitochondrial genes, most likely due to the co-evolution of nuclear and mitochondrial genomes. The non-protein coding regions of mitochondrial DNA (mtDNA) including the D-loop, tRNA and rRNA genes form a major component of this regulated expression unit. Here we present comparative analyses of the non-protein-coding regions from 27 Rattus norvegicus mtDNA sequences. There were two variable positions in 12S rRNA, 20 in 16S rRNA, eight within the tRNA genes and 13 in the D-loop. Only one of the three neutrality tests used demonstrated statistically significant evidence for selection in 16S rRNA and tRNA-Cys. Based on our analyses of conserved sequences, we propose that some of the variable nucleotide positions identified in 16S rRNA and tRNA-Cys, and the D-loop might be important for mitochondrial function and its regulation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1523736
- author
- Abhyankar, Avinash LU ; Park, Hee-Bok LU ; Tonolo, Giancarlo LU and Luthman, Holger LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 4
- issue
- 12
- article number
- e8148
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- wos:000272829500010
- pmid:19997590
- scopus:77949539305
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0008148
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Genetics Unit (013241550), Pediatrics/Urology/Gynecology/Endocrinology (013240400)
- id
- 4324cb97-11ba-45af-8a6e-3300b47c52e8 (old id 1523736)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19997590?dopt=Abstract
- date added to LUP
- 2016-04-04 09:29:17
- date last changed
- 2022-02-06 03:12:49
@article{4324cb97-11ba-45af-8a6e-3300b47c52e8, abstract = {{The proper function of mammalian mitochondria necessitates a coordinated expression of both nuclear and mitochondrial genes, most likely due to the co-evolution of nuclear and mitochondrial genomes. The non-protein coding regions of mitochondrial DNA (mtDNA) including the D-loop, tRNA and rRNA genes form a major component of this regulated expression unit. Here we present comparative analyses of the non-protein-coding regions from 27 Rattus norvegicus mtDNA sequences. There were two variable positions in 12S rRNA, 20 in 16S rRNA, eight within the tRNA genes and 13 in the D-loop. Only one of the three neutrality tests used demonstrated statistically significant evidence for selection in 16S rRNA and tRNA-Cys. Based on our analyses of conserved sequences, we propose that some of the variable nucleotide positions identified in 16S rRNA and tRNA-Cys, and the D-loop might be important for mitochondrial function and its regulation.}}, author = {{Abhyankar, Avinash and Park, Hee-Bok and Tonolo, Giancarlo and Luthman, Holger}}, issn = {{1932-6203}}, language = {{eng}}, number = {{12}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS ONE}}, title = {{Comparative sequence analysis of the non-protein-coding mitochondrial DNA of inbred rat strains.}}, url = {{https://lup.lub.lu.se/search/files/5337907/1530449.pdf}}, doi = {{10.1371/journal.pone.0008148}}, volume = {{4}}, year = {{2009}}, }