Women who gave birth to girls with Turner syndrome: maternal and neonatal characteristics
(2010) In Human Reproduction 25(6). p.1553-1560- Abstract
- Background: The aim was to identify maternal risk factors in women giving birth to girls with Turner syndrome (TS) and to describe the characteristics of newborns with TS. Methods: The Swedish Genetic Turner Register was cross-linked with the Swedish Medical Birth Register. Between 1973 and 2005, 494 children with TS were born. Maternal age, parity, height, smoking habits and neonatal characteristics; mode of delivery, gestational age, size at birth and Apgar score, were compared with women in the general population who gave birth to girls during the same period. Results: More women with advanced maternal age (40+) delivered girls with TS, 3.2% when compared with 1.8% in the general population [OR 1.83, 95% confidence interval (CI)... (More)
- Background: The aim was to identify maternal risk factors in women giving birth to girls with Turner syndrome (TS) and to describe the characteristics of newborns with TS. Methods: The Swedish Genetic Turner Register was cross-linked with the Swedish Medical Birth Register. Between 1973 and 2005, 494 children with TS were born. Maternal age, parity, height, smoking habits and neonatal characteristics; mode of delivery, gestational age, size at birth and Apgar score, were compared with women in the general population who gave birth to girls during the same period. Results: More women with advanced maternal age (40+) delivered girls with TS, 3.2% when compared with 1.8% in the general population [OR 1.83, 95% confidence interval (CI) 1.09-3.08, after adjustment for year of birth]. Maternal height was inversely associated with TS pregnancies (P = 0.005). Late preterm birth occurred in newborns with TS in 10.5% when compared with 4.8% in the general population (OR 2.23; 95% CI: 1.67-2.97, after adjustment for year of birth and maternal age). Newborns with TS had birthweight less than -2SD in 17.8% and birth length less than -2SD in 21.0% when compared with 3.5 and 3.4%, in the general population (OR 6.55; 95% CI: 5.12-8.38 and OR 8.69; 95% CI: 6.89-10.97, after adjustment for year of birth and maternal age). Conclusion: Advanced maternal age and short stature were risk factors for giving birth to a girl with TS. More TS girls were born late preterm and were smaller for gestational age than non-TS girls in the general population. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1616785
- author
- Hagman, A. ; Wennerholm, U. -B. ; Källén, Karin LU ; Barrenas, M. -L. ; Landin-Wilhelmsen, K. ; Hanson, C. and Bryman, I.
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- pregnancy, Turner syndrome, karyotype, maternal characteristics, neonatal
- in
- Human Reproduction
- volume
- 25
- issue
- 6
- pages
- 1553 - 1560
- publisher
- Oxford University Press
- external identifiers
-
- wos:000277988200027
- scopus:77952832727
- ISSN
- 0268-1161
- DOI
- 10.1093/humrep/deq060
- language
- English
- LU publication?
- yes
- id
- 3fa975b0-5470-4b52-ac86-4d9f6d033f2c (old id 1616785)
- date added to LUP
- 2016-04-01 10:31:10
- date last changed
- 2022-01-25 23:59:56
@article{3fa975b0-5470-4b52-ac86-4d9f6d033f2c,
abstract = {{Background: The aim was to identify maternal risk factors in women giving birth to girls with Turner syndrome (TS) and to describe the characteristics of newborns with TS. Methods: The Swedish Genetic Turner Register was cross-linked with the Swedish Medical Birth Register. Between 1973 and 2005, 494 children with TS were born. Maternal age, parity, height, smoking habits and neonatal characteristics; mode of delivery, gestational age, size at birth and Apgar score, were compared with women in the general population who gave birth to girls during the same period. Results: More women with advanced maternal age (40+) delivered girls with TS, 3.2% when compared with 1.8% in the general population [OR 1.83, 95% confidence interval (CI) 1.09-3.08, after adjustment for year of birth]. Maternal height was inversely associated with TS pregnancies (P = 0.005). Late preterm birth occurred in newborns with TS in 10.5% when compared with 4.8% in the general population (OR 2.23; 95% CI: 1.67-2.97, after adjustment for year of birth and maternal age). Newborns with TS had birthweight less than -2SD in 17.8% and birth length less than -2SD in 21.0% when compared with 3.5 and 3.4%, in the general population (OR 6.55; 95% CI: 5.12-8.38 and OR 8.69; 95% CI: 6.89-10.97, after adjustment for year of birth and maternal age). Conclusion: Advanced maternal age and short stature were risk factors for giving birth to a girl with TS. More TS girls were born late preterm and were smaller for gestational age than non-TS girls in the general population.}},
author = {{Hagman, A. and Wennerholm, U. -B. and Källén, Karin and Barrenas, M. -L. and Landin-Wilhelmsen, K. and Hanson, C. and Bryman, I.}},
issn = {{0268-1161}},
keywords = {{pregnancy; Turner syndrome; karyotype; maternal characteristics; neonatal}},
language = {{eng}},
number = {{6}},
pages = {{1553--1560}},
publisher = {{Oxford University Press}},
series = {{Human Reproduction}},
title = {{Women who gave birth to girls with Turner syndrome: maternal and neonatal characteristics}},
url = {{http://dx.doi.org/10.1093/humrep/deq060}},
doi = {{10.1093/humrep/deq060}},
volume = {{25}},
year = {{2010}},
}