Experience-dependent plasticity of white-matter microstructure extends into old age
(2010) In Neuropsychologia 48. p.3878-3883- Abstract
- Experience-dependent alterations in the human brain's white-matter microstructure occur in early adulthood, but it is unknown whether such plasticity extends throughout life. We used cognitive training, diffusion-tensor imaging (DTI), and structural MRI to investigate plasticity of the white-matter tracts that connect the left and right hemisphere of the frontal lobes. Over a period of about 180 days, 20 younger adults and 12 older adults trained for a total of one hundred and one 1-h sessions on a set of three working memory, three episodic memory, and six perceptual speed tasks. Control groups were assessed at pre- and post-test. Training affected several DTI metrics and increased the area of the anterior part of the corpus callosum.... (More)
- Experience-dependent alterations in the human brain's white-matter microstructure occur in early adulthood, but it is unknown whether such plasticity extends throughout life. We used cognitive training, diffusion-tensor imaging (DTI), and structural MRI to investigate plasticity of the white-matter tracts that connect the left and right hemisphere of the frontal lobes. Over a period of about 180 days, 20 younger adults and 12 older adults trained for a total of one hundred and one 1-h sessions on a set of three working memory, three episodic memory, and six perceptual speed tasks. Control groups were assessed at pre- and post-test. Training affected several DTI metrics and increased the area of the anterior part of the corpus callosum. These alterations were of similar magnitude in younger and older adults. The findings indicate that experience-dependent plasticity of white-matter microstructure extends into old age and that disruptions of structural interhemispheric connectivity in old age, which are pronounced in aging, are modifiable by experience and amenable to treatment. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1688538
- author
- Lövdén, Martin LU ; Bodammer, Nils Christian ; Kühn, Simone ; Kaufmann, Jörn ; Schütze, Hartmut ; Tempelmann, Claus ; Heinze, Hans-Jochen ; Düzel, Emrah ; Schmiedek, Florian and Lindenberger, Ulman
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neuropsychologia
- volume
- 48
- pages
- 3878 - 3883
- publisher
- Elsevier
- external identifiers
-
- wos:000285036600019
- scopus:78149407234
- pmid:20816877
- ISSN
- 1873-3514
- DOI
- 10.1016/j.neuropsychologia.2010.08.026
- language
- English
- LU publication?
- yes
- id
- 99d6557b-c4d2-4eff-ac3b-fd92bfc68a5e (old id 1688538)
- date added to LUP
- 2016-04-01 11:12:00
- date last changed
- 2022-02-03 00:32:31
@article{99d6557b-c4d2-4eff-ac3b-fd92bfc68a5e, abstract = {{Experience-dependent alterations in the human brain's white-matter microstructure occur in early adulthood, but it is unknown whether such plasticity extends throughout life. We used cognitive training, diffusion-tensor imaging (DTI), and structural MRI to investigate plasticity of the white-matter tracts that connect the left and right hemisphere of the frontal lobes. Over a period of about 180 days, 20 younger adults and 12 older adults trained for a total of one hundred and one 1-h sessions on a set of three working memory, three episodic memory, and six perceptual speed tasks. Control groups were assessed at pre- and post-test. Training affected several DTI metrics and increased the area of the anterior part of the corpus callosum. These alterations were of similar magnitude in younger and older adults. The findings indicate that experience-dependent plasticity of white-matter microstructure extends into old age and that disruptions of structural interhemispheric connectivity in old age, which are pronounced in aging, are modifiable by experience and amenable to treatment.}}, author = {{Lövdén, Martin and Bodammer, Nils Christian and Kühn, Simone and Kaufmann, Jörn and Schütze, Hartmut and Tempelmann, Claus and Heinze, Hans-Jochen and Düzel, Emrah and Schmiedek, Florian and Lindenberger, Ulman}}, issn = {{1873-3514}}, language = {{eng}}, pages = {{3878--3883}}, publisher = {{Elsevier}}, series = {{Neuropsychologia}}, title = {{Experience-dependent plasticity of white-matter microstructure extends into old age}}, url = {{http://dx.doi.org/10.1016/j.neuropsychologia.2010.08.026}}, doi = {{10.1016/j.neuropsychologia.2010.08.026}}, volume = {{48}}, year = {{2010}}, }