A factor analytic approach to symptom patterns in dementia.
(2010) In International Journal of Alzheimer's Disease- Abstract
- Previous publications have shown a high diagnostic sensitivity and specificity of three short clinical rating scales for Alzheimer's disease (AD), frontotemporal dementia (FTD), and vascular dementia (VaD) validated against neuropathological (NP) diagnoses. In this study, the aim was to perform an exploratory factor analysis of the items in these clinical rating scales. The study included 190 patients with postmortem diagnoses of AD (n = 74), VaD (n = 33), mixed AD/VaD (n = 31), or FTD (n = 52). The factor analysis produced three strong factors. Factor 1 contained items describing cerebrovascular disease, similar to the Hachinski Ischemic Score. Factor 2 enclosed major clinical characteristics of FTD, and factor 3 showed a striking... (More)
- Previous publications have shown a high diagnostic sensitivity and specificity of three short clinical rating scales for Alzheimer's disease (AD), frontotemporal dementia (FTD), and vascular dementia (VaD) validated against neuropathological (NP) diagnoses. In this study, the aim was to perform an exploratory factor analysis of the items in these clinical rating scales. The study included 190 patients with postmortem diagnoses of AD (n = 74), VaD (n = 33), mixed AD/VaD (n = 31), or FTD (n = 52). The factor analysis produced three strong factors. Factor 1 contained items describing cerebrovascular disease, similar to the Hachinski Ischemic Score. Factor 2 enclosed major clinical characteristics of FTD, and factor 3 showed a striking similarity to the AD scale. A fourth symptom cluster was described by perception and expression of emotions. The factor analyses strongly support the construct validity of the diagnostic rating scales. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1777169
- author
- Gustafson, Lars LU ; Erikson, Catarina LU ; Warkentin, Siegbert LU ; Brun, Arne LU ; Englund, Elisabet LU and Passant, Ulla LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Alzheimer's Disease
- publisher
- Hindawi Limited
- external identifiers
-
- pmid:21253531
- scopus:79952127115
- pmid:21253531
- ISSN
- 2090-0252
- DOI
- 10.4061/2011/632604
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Neurosurgery (013026000), Department of Psychogeriatrics (013304000)
- id
- 43d4e72d-b03f-4ad8-be1d-fd45a3881341 (old id 1777169)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21253531?dopt=Abstract
- date added to LUP
- 2016-04-04 06:59:15
- date last changed
- 2022-01-29 01:33:24
@article{43d4e72d-b03f-4ad8-be1d-fd45a3881341, abstract = {{Previous publications have shown a high diagnostic sensitivity and specificity of three short clinical rating scales for Alzheimer's disease (AD), frontotemporal dementia (FTD), and vascular dementia (VaD) validated against neuropathological (NP) diagnoses. In this study, the aim was to perform an exploratory factor analysis of the items in these clinical rating scales. The study included 190 patients with postmortem diagnoses of AD (n = 74), VaD (n = 33), mixed AD/VaD (n = 31), or FTD (n = 52). The factor analysis produced three strong factors. Factor 1 contained items describing cerebrovascular disease, similar to the Hachinski Ischemic Score. Factor 2 enclosed major clinical characteristics of FTD, and factor 3 showed a striking similarity to the AD scale. A fourth symptom cluster was described by perception and expression of emotions. The factor analyses strongly support the construct validity of the diagnostic rating scales.}}, author = {{Gustafson, Lars and Erikson, Catarina and Warkentin, Siegbert and Brun, Arne and Englund, Elisabet and Passant, Ulla}}, issn = {{2090-0252}}, language = {{eng}}, publisher = {{Hindawi Limited}}, series = {{International Journal of Alzheimer's Disease}}, title = {{A factor analytic approach to symptom patterns in dementia.}}, url = {{https://lup.lub.lu.se/search/files/5119393/1787785.pdf}}, doi = {{10.4061/2011/632604}}, year = {{2010}}, }