Bile retinoids imprint intestinal CD103(+) dendritic cells with the ability to generate gut-tropic T cells.
(2011) In Mucosal Immunology 4. p.438-447- Abstract
- Small intestinal lamina propria (SI-LP) CD103(+) dendritic cells (DCs) are imprinted with an ability to metabolize vitamin A (retinol), a property underlying their enhanced capacity to induce the gut-homing receptors CC chemokine receptor-9 and α4β7 on responding T cells. In this study, we demonstrate that imprinting of CD103(+) DCs is itself critically dependent on vitamin A and occurs locally within the small intestine (SI). The major vitamin A metabolite retinoic acid (RA) induced retinol-metabolizing activity in DCs both in vitro and in vivo, suggesting a direct role for RA in this process. Consistent with this, SI-LP CD103(+) DCs constitutively received RA signals in vivo at significantly higher levels than did colonic CD103(+) DCs.... (More)
- Small intestinal lamina propria (SI-LP) CD103(+) dendritic cells (DCs) are imprinted with an ability to metabolize vitamin A (retinol), a property underlying their enhanced capacity to induce the gut-homing receptors CC chemokine receptor-9 and α4β7 on responding T cells. In this study, we demonstrate that imprinting of CD103(+) DCs is itself critically dependent on vitamin A and occurs locally within the small intestine (SI). The major vitamin A metabolite retinoic acid (RA) induced retinol-metabolizing activity in DCs both in vitro and in vivo, suggesting a direct role for RA in this process. Consistent with this, SI-LP CD103(+) DCs constitutively received RA signals in vivo at significantly higher levels than did colonic CD103(+) DCs. Remarkably, SI CD103(+) DCs remained imprinted in mice depleted of dietary but not of systemic retinol. We found that bile contained high levels of retinol, induced RA receptor-dependent retinol-metabolizing activity in bone marrow-derived DCs, and imprinted these cells with the ability to generate gut-tropic T cells. Taken together, these results suggest a novel and unexpected role for bile in SI-LP CD103(+) DC imprinting.Mucosal Immunology advance online publication 2 February 2011. doi:10.1038/mi.2010.91. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1832316
- author
- Jaensson Gyllenbäck, Elin LU ; Kotarsky, Knut LU ; Zapata, Fernando LU ; Persson, E K ; Gundersen, T E ; Blomhoff, R and Agace, William LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Mucosal Immunology
- volume
- 4
- pages
- 438 - 447
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000291721500009
- pmid:21289617
- scopus:79959396339
- ISSN
- 1933-0219
- DOI
- 10.1038/mi.2010.91
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Experimental Medical Science (013210000), Division of Nursing (Closed 2012) (013065000), Mucosal Immunology (013212072)
- id
- 65425a3e-bc7e-4a6d-94d1-ea9e8d6c2f4d (old id 1832316)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21289617?dopt=Abstract
- date added to LUP
- 2016-04-04 07:07:39
- date last changed
- 2022-01-29 01:44:12
@article{65425a3e-bc7e-4a6d-94d1-ea9e8d6c2f4d, abstract = {{Small intestinal lamina propria (SI-LP) CD103(+) dendritic cells (DCs) are imprinted with an ability to metabolize vitamin A (retinol), a property underlying their enhanced capacity to induce the gut-homing receptors CC chemokine receptor-9 and α4β7 on responding T cells. In this study, we demonstrate that imprinting of CD103(+) DCs is itself critically dependent on vitamin A and occurs locally within the small intestine (SI). The major vitamin A metabolite retinoic acid (RA) induced retinol-metabolizing activity in DCs both in vitro and in vivo, suggesting a direct role for RA in this process. Consistent with this, SI-LP CD103(+) DCs constitutively received RA signals in vivo at significantly higher levels than did colonic CD103(+) DCs. Remarkably, SI CD103(+) DCs remained imprinted in mice depleted of dietary but not of systemic retinol. We found that bile contained high levels of retinol, induced RA receptor-dependent retinol-metabolizing activity in bone marrow-derived DCs, and imprinted these cells with the ability to generate gut-tropic T cells. Taken together, these results suggest a novel and unexpected role for bile in SI-LP CD103(+) DC imprinting.Mucosal Immunology advance online publication 2 February 2011. doi:10.1038/mi.2010.91.}}, author = {{Jaensson Gyllenbäck, Elin and Kotarsky, Knut and Zapata, Fernando and Persson, E K and Gundersen, T E and Blomhoff, R and Agace, William}}, issn = {{1933-0219}}, language = {{eng}}, pages = {{438--447}}, publisher = {{Nature Publishing Group}}, series = {{Mucosal Immunology}}, title = {{Bile retinoids imprint intestinal CD103(+) dendritic cells with the ability to generate gut-tropic T cells.}}, url = {{http://dx.doi.org/10.1038/mi.2010.91}}, doi = {{10.1038/mi.2010.91}}, volume = {{4}}, year = {{2011}}, }