Postnatal Decrease in Circulating Insulin-Like Growth Factor-I and Low Brain Volumes in Very Preterm Infants.

Hansen-Pupp, Ingrid; Hövel, Holger; Hellström, Ann; Hellström-Westas, Lena; Löfqvist, Chatarina; Larsson, Elna-Marie; Lazeyras, Francois; Fellman, Vineta; Hüppi, Petra S; Ley, David

Postnatal Decrease in Circulating Insulin-Like Growth Factor-I and Low Brain Volumes in Very Preterm Infants.

Mark

; Hövel, Holger ^LU ; Hellström, Ann ; Hellström-Westas, Lena ^LU ; Löfqvist, Chatarina ; Larsson, Elna-Marie ^LU ; Lazeyras, Francois ; Fellman, Vineta ^LU

; Hüppi, Petra S and Ley, David ^LU (2011) In The Journal of clinical endocrinology and metabolism 96(4). p.1129-1135

Abstract: Context: IGF-I and IGF binding protein-3 (IGFBP-3) are essential for growth and maturation of the developing brain. Objective: The aim of this study was to evaluate the association between postnatal serum concentrations of IGF-I and IGFBP-3 and brain volumes at term in very preterm infants. Design: Fifty-one infants with a mean (sd) gestational age (GA) of 26.4 (1.9) wk and birth weight (BW) of 888 (288) g were studied, with weekly blood sampling of IGF-I and IGFBP-3 from birth until 35 gestational weeks (GW) and daily calculation of protein and caloric intake. Magnetic resonance images obtained at 40 GW were segmented into total brain, cerebellar, cerebrospinal fluid, gray matter, and unmyelinated white matter volumes. Main Outcome... (More); Context: IGF-I and IGF binding protein-3 (IGFBP-3) are essential for growth and maturation of the developing brain. Objective: The aim of this study was to evaluate the association between postnatal serum concentrations of IGF-I and IGFBP-3 and brain volumes at term in very preterm infants. Design: Fifty-one infants with a mean (sd) gestational age (GA) of 26.4 (1.9) wk and birth weight (BW) of 888 (288) g were studied, with weekly blood sampling of IGF-I and IGFBP-3 from birth until 35 gestational weeks (GW) and daily calculation of protein and caloric intake. Magnetic resonance images obtained at 40 GW were segmented into total brain, cerebellar, cerebrospinal fluid, gray matter, and unmyelinated white matter volumes. Main Outcome Measures: We evaluated brain growth by measuring brain volumes using magnetic resonance imaging. Results: Mean IGF-I concentrations from birth to 35 GW correlated with total brain volume, unmyelinated white matter volume, gray matter volume, and cerebellar volume [r = 0.55 (P < 0.001); r = 0.55 (P < 0.001); r = 0.44 (P = 0.002); and r = 0.58 (P < 0.001), respectively]. Similar correlations were observed for IGFBP-3 concentrations. Correlations remained after adjustment for GA, mean protein and caloric intakes, gender, severe brain damage, and steroid treatment. Protein and caloric intakes were not related to brain volumes. Infants with BW small for GA had lower mean concentrations of IGF-I (P = 0.006) and smaller brain volumes (P = 0.001-0.013) than infants with BW appropriate for GA. Conclusion: Postnatal IGF-I and IGFBP-3 concentrations are positively associated with brain volumes at 40 GW in very preterm infants. Normalization of the IGF-I axis, directly or indirectly, may support normal brain development in very preterm infants. (Less)

Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/1832326

author

Hansen-Pupp, Ingrid ^LU

; Hövel, Holger ^LU ; Hellström, Ann ; Hellström-Westas, Lena ^LU ; Löfqvist, Chatarina ; Larsson, Elna-Marie ^LU ; Lazeyras, Francois ; Fellman, Vineta ^LU

; Hüppi, Petra S and Ley, David ^LU

organization

publishing date

2011

type

Contribution to journal

publication status

published

subject

Endocrinology and Diabetes

keywords

Brain/anatomy & histology, Cohort Studies, Down-Regulation, Female, Gestational Age, Humans, Infant Nutritional Physiological Phenomena, Infant, Newborn, Infant, Premature/blood, Infant, Very Low Birth Weight/blood, Insulin-Like Growth Factor Binding Protein 3/blood, Insulin-Like Growth Factor I/analysis, Magnetic Resonance Imaging, Male, Organ Size, Radiography

in

The Journal of clinical endocrinology and metabolism

volume

96

issue

4

pages

7 pages

publisher

Oxford University Press

external identifiers

wos:000289242800058
pmid:21289247
scopus:79953906297
pmid:21289247

ISSN

1945-7197

DOI

10.1210/jc.2010-2440

language

English

LU publication?

yes

id

52a8c862-2564-467f-a8b0-f71355c27446 (old id 1832326)

alternative location

http://www.ncbi.nlm.nih.gov/pubmed/21289247?dopt=Abstract

date added to LUP

2016-04-04 09:24:10

date last changed

2023-09-05 23:03:35

@article{52a8c862-2564-467f-a8b0-f71355c27446,
  abstract     = {{Context: IGF-I and IGF binding protein-3 (IGFBP-3) are essential for growth and maturation of the developing brain. Objective: The aim of this study was to evaluate the association between postnatal serum concentrations of IGF-I and IGFBP-3 and brain volumes at term in very preterm infants. Design: Fifty-one infants with a mean (sd) gestational age (GA) of 26.4 (1.9) wk and birth weight (BW) of 888 (288) g were studied, with weekly blood sampling of IGF-I and IGFBP-3 from birth until 35 gestational weeks (GW) and daily calculation of protein and caloric intake. Magnetic resonance images obtained at 40 GW were segmented into total brain, cerebellar, cerebrospinal fluid, gray matter, and unmyelinated white matter volumes. Main Outcome Measures: We evaluated brain growth by measuring brain volumes using magnetic resonance imaging. Results: Mean IGF-I concentrations from birth to 35 GW correlated with total brain volume, unmyelinated white matter volume, gray matter volume, and cerebellar volume [r = 0.55 (P &lt; 0.001); r = 0.55 (P &lt; 0.001); r = 0.44 (P = 0.002); and r = 0.58 (P &lt; 0.001), respectively]. Similar correlations were observed for IGFBP-3 concentrations. Correlations remained after adjustment for GA, mean protein and caloric intakes, gender, severe brain damage, and steroid treatment. Protein and caloric intakes were not related to brain volumes. Infants with BW small for GA had lower mean concentrations of IGF-I (P = 0.006) and smaller brain volumes (P = 0.001-0.013) than infants with BW appropriate for GA. Conclusion: Postnatal IGF-I and IGFBP-3 concentrations are positively associated with brain volumes at 40 GW in very preterm infants. Normalization of the IGF-I axis, directly or indirectly, may support normal brain development in very preterm infants.}},
  author       = {{Hansen-Pupp, Ingrid and Hövel, Holger and Hellström, Ann and Hellström-Westas, Lena and Löfqvist, Chatarina and Larsson, Elna-Marie and Lazeyras, Francois and Fellman, Vineta and Hüppi, Petra S and Ley, David}},
  issn         = {{1945-7197}},
  keywords     = {{Brain/anatomy & histology; Cohort Studies; Down-Regulation; Female; Gestational Age; Humans; Infant Nutritional Physiological Phenomena; Infant, Newborn; Infant, Premature/blood; Infant, Very Low Birth Weight/blood; Insulin-Like Growth Factor Binding Protein 3/blood; Insulin-Like Growth Factor I/analysis; Magnetic Resonance Imaging; Male; Organ Size; Radiography}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{1129--1135}},
  publisher    = {{Oxford University Press}},
  series       = {{The Journal of clinical endocrinology and metabolism}},
  title        = {{Postnatal Decrease in Circulating Insulin-Like Growth Factor-I and Low Brain Volumes in Very Preterm Infants.}},
  url          = {{https://lup.lub.lu.se/search/files/5314696/1852007.pdf}},
  doi          = {{10.1210/jc.2010-2440}},
  volume       = {{96}},
  year         = {{2011}},
}

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Postnatal Decrease in Circulating Insulin-Like Growth Factor-I and Low Brain Volumes in Very Preterm Infants.