Temporal trends of phthalate exposures during 2007–2010 in Swedish pregnant women
(2018) In Journal of Exposure Science and Environmental Epidemiology 28(5). p.437-447- Abstract
Background: The general population is exposed to phthalates, a group of chemicals with strong evidence for endocrine disrupting properties, commonly used in a large number of consumer products. Based on published research and evidence compiled by environmental agencies, certain phthalate applications and products have become restricted, leading to an increasing number of “new generation compounds” coming onto the market during recent years replacing older phthalates. Some examples of such newer compounds are di-iso-nonyl phthalate (DiNP), di-iso-decyl phthalate (DiDP), and most recently di-isononyl-cyclohexane-1,2-dicarboxylate (DiNCH). Objectives: In order to evaluate temporal trends in phthalate exposure, first trimester urinary... (More)
Background: The general population is exposed to phthalates, a group of chemicals with strong evidence for endocrine disrupting properties, commonly used in a large number of consumer products. Based on published research and evidence compiled by environmental agencies, certain phthalate applications and products have become restricted, leading to an increasing number of “new generation compounds” coming onto the market during recent years replacing older phthalates. Some examples of such newer compounds are di-iso-nonyl phthalate (DiNP), di-iso-decyl phthalate (DiDP), and most recently di-isononyl-cyclohexane-1,2-dicarboxylate (DiNCH). Objectives: In order to evaluate temporal trends in phthalate exposure, first trimester urinary biomarkers of phthalates were measured in the Swedish SELMA study over a period of 2.5 years (2007–2010). Methods: We collected first morning void urine samples around week 10 of pregnancy from 1651 pregnant women. Spot samples were analyzed for 13 phthalate metabolites and one phthalate replacement and least square geometric mean (LSGM) levels of the metabolites were compared between the sampling years when adjusted for potential confounders. Results: All 14 metabolites were detectable in more than 99% of the SELMA subjects. The levels were generally comparable to other studies, but the SELMA subjects showed slightly higher exposure to butyl-benzyl phthalate (BBzP) and di-butyl phthalate (DBP). Di-ethyl-hexyl phthalate (DEHP) metabolites levels decreased while DiNP, DiDP/di-2-propylheptyl phthalate (DPHP), and DiNCH metabolites levels increased during the sampling period. Conclusions: Urinary metabolite levels of the older phthalates and more recently introduced phthalate replacement compound changed during the short sampling period in this Swedish pregnancy cohort. Our results indicate that replacement of phthalates can make an impact on human exposure to these chemicals. During this particularly vulnerable stage of life, phthalate exposures are of particular concern as the impacts, though not immediately noticeable, may increase the risk for health effects later in life.
(Less)
- author
- Shu, Huan ; Jönsson, Bo A.G. LU ; Gennings, Chris ; Svensson, Åke LU ; Nånberg, Eewa ; Lindh, Christian H. LU ; Knutz, Malin ; Takaro, Tim K. and Bornehag, Carl Gustaf LU
- organization
- publishing date
- 2018-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- DiNCH, Endocrine disrupting chemicals, Exposure, Phthalates, Pregnant, SELMA-Study, Temporal
- in
- Journal of Exposure Science and Environmental Epidemiology
- volume
- 28
- issue
- 5
- pages
- 437 - 447
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85042354826
- pmid:29472621
- ISSN
- 1559-0631
- DOI
- 10.1038/s41370-018-0020-6
- language
- English
- LU publication?
- yes
- id
- 18695d98-fd7f-46ed-8d51-74e1a089d5c7
- date added to LUP
- 2018-03-12 09:25:28
- date last changed
- 2024-08-05 14:22:59
@article{18695d98-fd7f-46ed-8d51-74e1a089d5c7, abstract = {{<p>Background: The general population is exposed to phthalates, a group of chemicals with strong evidence for endocrine disrupting properties, commonly used in a large number of consumer products. Based on published research and evidence compiled by environmental agencies, certain phthalate applications and products have become restricted, leading to an increasing number of “new generation compounds” coming onto the market during recent years replacing older phthalates. Some examples of such newer compounds are di-iso-nonyl phthalate (DiNP), di-iso-decyl phthalate (DiDP), and most recently di-isononyl-cyclohexane-1,2-dicarboxylate (DiNCH). Objectives: In order to evaluate temporal trends in phthalate exposure, first trimester urinary biomarkers of phthalates were measured in the Swedish SELMA study over a period of 2.5 years (2007–2010). Methods: We collected first morning void urine samples around week 10 of pregnancy from 1651 pregnant women. Spot samples were analyzed for 13 phthalate metabolites and one phthalate replacement and least square geometric mean (LSGM) levels of the metabolites were compared between the sampling years when adjusted for potential confounders. Results: All 14 metabolites were detectable in more than 99% of the SELMA subjects. The levels were generally comparable to other studies, but the SELMA subjects showed slightly higher exposure to butyl-benzyl phthalate (BBzP) and di-butyl phthalate (DBP). Di-ethyl-hexyl phthalate (DEHP) metabolites levels decreased while DiNP, DiDP/di-2-propylheptyl phthalate (DPHP), and DiNCH metabolites levels increased during the sampling period. Conclusions: Urinary metabolite levels of the older phthalates and more recently introduced phthalate replacement compound changed during the short sampling period in this Swedish pregnancy cohort. Our results indicate that replacement of phthalates can make an impact on human exposure to these chemicals. During this particularly vulnerable stage of life, phthalate exposures are of particular concern as the impacts, though not immediately noticeable, may increase the risk for health effects later in life.</p>}}, author = {{Shu, Huan and Jönsson, Bo A.G. and Gennings, Chris and Svensson, Åke and Nånberg, Eewa and Lindh, Christian H. and Knutz, Malin and Takaro, Tim K. and Bornehag, Carl Gustaf}}, issn = {{1559-0631}}, keywords = {{DiNCH; Endocrine disrupting chemicals; Exposure; Phthalates; Pregnant; SELMA-Study; Temporal}}, language = {{eng}}, number = {{5}}, pages = {{437--447}}, publisher = {{Nature Publishing Group}}, series = {{Journal of Exposure Science and Environmental Epidemiology}}, title = {{Temporal trends of phthalate exposures during 2007–2010 in Swedish pregnant women}}, url = {{http://dx.doi.org/10.1038/s41370-018-0020-6}}, doi = {{10.1038/s41370-018-0020-6}}, volume = {{28}}, year = {{2018}}, }