IGF1 htSNPs in relation to IGF-1 levels in young women from high-risk breast cancer families: implications for early-onset breast cancer
Henningson, Maria LU ; Hietala, Maria LU ; Törngren, Therese LU ; Olsson, Håkan LU
and Jernström, Helena
LU
(2011)
In Familial Cancer
10(2).
p.173-185
- Abstract
- High levels of insulin-like growth factor-1 (IGF-1) have been associated with increased risk of developing several types of cancer including breast cancer. A set of nine haplotype tagging SNPs (htSNPs) in the IGF1 gene were associated with IGF-1 levels and prostate cancer in a Swedish population. We aimed to study the nine htSNPs in three haplotype blocks (block1: rs855211, rs35765, rs2162679; block2: rs1019731, rs7956547, rs5742632; and block3 rs2033178, rs7136446, rs6220) combined into diplotypes, and three additional SNPs (rs5742612, rs35765817, rs35455143) in relation to IGF-1 levels, BRCA status, the IGF1 CA-repeat microsatellite, and breast cancer in a population of 325 Swedish women from breast cancer high-risk families.... (More)
- High levels of insulin-like growth factor-1 (IGF-1) have been associated with increased risk of developing several types of cancer including breast cancer. A set of nine haplotype tagging SNPs (htSNPs) in the IGF1 gene were associated with IGF-1 levels and prostate cancer in a Swedish population. We aimed to study the nine htSNPs in three haplotype blocks (block1: rs855211, rs35765, rs2162679; block2: rs1019731, rs7956547, rs5742632; and block3 rs2033178, rs7136446, rs6220) combined into diplotypes, and three additional SNPs (rs5742612, rs35765817, rs35455143) in relation to IGF-1 levels, BRCA status, the IGF1 CA-repeat microsatellite, and breast cancer in a population of 325 Swedish women from breast cancer high-risk families. Questionnaire data and blood samples for IGF-1 and genetic analyses were obtained twice during the menstrual cycle from 269 women aged 40 years or younger. SNP analyses were also performed in 56 BRCA1/2 mutation carriers. Women (n = 14) with any rare variant block1 diplotype had higher odds to be BRCA1 mutation carriers OR 4.1 (95% CI 1.4-12.2), to lack the common IGF1 19 CA-repeat allele OR 33.3 (95% CI 6.6-166.7), and were more likely to develop early-onset breast cancer (Log Rank P < 0.001) than women with common block1 diplotypes. In the subgroup of BRCA1 mutation carriers, block1 rare diplotypes were associated with earlier diagnosis (Log Rank P = 0.031). No association was found between IGF-1 levels and individual SNPs or diplotypes. If confirmed, these rare diplotypes may identify women with particularly high risk for early-onset breast cancer and this group should be included in forthcoming studies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1986005
- author
- Henningson, Maria
LU
; Hietala, Maria
LU
; Törngren, Therese
LU
; Olsson, Håkan
LU
and Jernström, Helena
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- BRCA1/2, Insulin-like growth factor-1, Oral contraception, IGF1, polymorphism, IGF1 diplotype, Breast cancer
- in
- Familial Cancer
- volume
- 10
- issue
- 2
- pages
- 173 - 185
- publisher
- Springer
- external identifiers
-
- wos:000290937500001
- scopus:79958113111
- pmid:21113804
- ISSN
- 1389-9600
- DOI
- 10.1007/s10689-010-9404-z
- language
- English
- LU publication?
- yes
- id
- 7541eb57-9e16-4dd1-ab8c-0235d139b8a1 (old id 1986005)
- date added to LUP
- 2016-04-01 10:28:03
- date last changed
- 2022-01-25 23:31:50
@article{7541eb57-9e16-4dd1-ab8c-0235d139b8a1,
abstract = {{High levels of insulin-like growth factor-1 (IGF-1) have been associated with increased risk of developing several types of cancer including breast cancer. A set of nine haplotype tagging SNPs (htSNPs) in the IGF1 gene were associated with IGF-1 levels and prostate cancer in a Swedish population. We aimed to study the nine htSNPs in three haplotype blocks (block1: rs855211, rs35765, rs2162679; block2: rs1019731, rs7956547, rs5742632; and block3 rs2033178, rs7136446, rs6220) combined into diplotypes, and three additional SNPs (rs5742612, rs35765817, rs35455143) in relation to IGF-1 levels, BRCA status, the IGF1 CA-repeat microsatellite, and breast cancer in a population of 325 Swedish women from breast cancer high-risk families. Questionnaire data and blood samples for IGF-1 and genetic analyses were obtained twice during the menstrual cycle from 269 women aged 40 years or younger. SNP analyses were also performed in 56 BRCA1/2 mutation carriers. Women (n = 14) with any rare variant block1 diplotype had higher odds to be BRCA1 mutation carriers OR 4.1 (95% CI 1.4-12.2), to lack the common IGF1 19 CA-repeat allele OR 33.3 (95% CI 6.6-166.7), and were more likely to develop early-onset breast cancer (Log Rank P < 0.001) than women with common block1 diplotypes. In the subgroup of BRCA1 mutation carriers, block1 rare diplotypes were associated with earlier diagnosis (Log Rank P = 0.031). No association was found between IGF-1 levels and individual SNPs or diplotypes. If confirmed, these rare diplotypes may identify women with particularly high risk for early-onset breast cancer and this group should be included in forthcoming studies.}},
author = {{Henningson, Maria and Hietala, Maria and Törngren, Therese and Olsson, Håkan and Jernström, Helena}},
issn = {{1389-9600}},
keywords = {{BRCA1/2; Insulin-like growth factor-1; Oral contraception; IGF1; polymorphism; IGF1 diplotype; Breast cancer}},
language = {{eng}},
number = {{2}},
pages = {{173--185}},
publisher = {{Springer}},
series = {{Familial Cancer}},
title = {{IGF1 htSNPs in relation to IGF-1 levels in young women from high-risk breast cancer families: implications for early-onset breast cancer}},
url = {{https://lup.lub.lu.se/search/files/1868986/2203256.pdf}},
doi = {{10.1007/s10689-010-9404-z}},
volume = {{10}},
year = {{2011}},
}