Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorption
(2005) In Journal of Bone and Mineral Research 20(12). p.2224-2232- Abstract
- Using human peripheral blood CD14(+) osteoclast precursors, we show that testosterone directly inhibits osteoclast formation and bone resorption at physiological concentrations. Instead, estrogen has no direct effects, whereas its action seems to be mediated through osteoblasts by producing osteoprotegerin. Both estrogen and testosterone acts through their cognate receptors.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/212151
- author
- Michael, H ; Härkönen, Pirkko LU ; Vaananen, H K and Hentunen, T A
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- estrogen receptor, androgen receptor, estrogen, testosterone, human CD14(+) monocytes, bone resorption, osteoclast formation
- in
- Journal of Bone and Mineral Research
- volume
- 20
- issue
- 12
- pages
- 2224 - 2232
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:16294275
- wos:000233517700016
- scopus:27744431505
- pmid:16294275
- ISSN
- 1523-4681
- DOI
- 10.1359/JBMR.050803
- language
- English
- LU publication?
- yes
- additional info
- Department affilation moved from v1000588 (Tumour Biology, Malmö) to v1000562 (Department of Translational Medicine) on 2016-01-18 14:39:30.
- id
- 00603203-1c97-4f51-994b-d408a4cb4468 (old id 212151)
- date added to LUP
- 2016-04-01 11:39:33
- date last changed
- 2022-03-12 22:44:52
@article{00603203-1c97-4f51-994b-d408a4cb4468, abstract = {{Using human peripheral blood CD14(+) osteoclast precursors, we show that testosterone directly inhibits osteoclast formation and bone resorption at physiological concentrations. Instead, estrogen has no direct effects, whereas its action seems to be mediated through osteoblasts by producing osteoprotegerin. Both estrogen and testosterone acts through their cognate receptors.}}, author = {{Michael, H and Härkönen, Pirkko and Vaananen, H K and Hentunen, T A}}, issn = {{1523-4681}}, keywords = {{estrogen receptor; androgen receptor; estrogen; testosterone; human CD14(+) monocytes; bone resorption; osteoclast formation}}, language = {{eng}}, number = {{12}}, pages = {{2224--2232}}, publisher = {{Wiley-Blackwell}}, series = {{Journal of Bone and Mineral Research}}, title = {{Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorption}}, url = {{http://dx.doi.org/10.1359/JBMR.050803}}, doi = {{10.1359/JBMR.050803}}, volume = {{20}}, year = {{2005}}, }