Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies

Key, T. J.; Appleby, P. N.; Reeves, G. K.; Roddam, A. W.; Helzlsouer, K. J.; Alberg, A. J.; Rollison, D. E.; Dorgan, J. F.; Brinton, L. A.; Overvad, K.; Kaaks, R.; Trichopoulou, A.; Clavel-Chapelon, F.; Panico, S.; Duell, E. J.; Peeters, P. H. M.; Rinaldi, S.; Riboli, E.; Fentiman, I. S.; Dowsett, M.; Manjer, Jonas; Lenner, P.; Hallmans, G.; Baglietto, L.; English, D. R.; Giles, G. G.; Hopper, J. L.; Severi, G.; Morris, H. A.; Koenig, K.; Zeleniuch-Jacquotte, A.; Arslan, A. A.; Toniolo, P.; Shore, R. E.; Krogh, V.; Micheli, A.; Berrino, F.; Muti, P.; Barrett-Connor, E.; Laughlin, G. A.; Kabuto, M.; Akiba, S.; Stevens, R. G.; Neriishi, K.; Land, C. E.; Cauley, J. A.; Lui, Li Yung; Cummings, Steven R.; Gunter, M. J.; Rohan, T. E.

Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies

Mark

Key, T. J. ; Appleby, P. N. ; Reeves, G. K. ; Roddam, A. W. ; Helzlsouer, K. J. ; Alberg, A. J. ; Rollison, D. E. ; Dorgan, J. F. ; Brinton, L. A. and Overvad, K. , et al. (2011) In British Journal of Cancer 105(5). p.709-722

Abstract: BACKGROUND: Breast cancer risk for postmenopausal women is positively associated with circulating concentrations of oestrogens and androgens, but the determinants of these hormones are not well understood. METHODS: Cross-sectional analyses of breast cancer risk factors and circulating hormone concentrations in more than 6000 postmenopausal women controls in 13 prospective studies. RESULTS: Concentrations of all hormones were lower in older than younger women, with the largest difference for dehydroepiandrosterone sulphate (DHEAS), whereas sex hormone-binding globulin (SHBG) was higher in the older women. Androgens were lower in women with bilateral ovariectomy than in naturally postmenopausal women, with the largest difference for free... (More); BACKGROUND: Breast cancer risk for postmenopausal women is positively associated with circulating concentrations of oestrogens and androgens, but the determinants of these hormones are not well understood. METHODS: Cross-sectional analyses of breast cancer risk factors and circulating hormone concentrations in more than 6000 postmenopausal women controls in 13 prospective studies. RESULTS: Concentrations of all hormones were lower in older than younger women, with the largest difference for dehydroepiandrosterone sulphate (DHEAS), whereas sex hormone-binding globulin (SHBG) was higher in the older women. Androgens were lower in women with bilateral ovariectomy than in naturally postmenopausal women, with the largest difference for free testosterone. All hormones were higher in obese than lean women, with the largest difference for free oestradiol, whereas SHBG was lower in obese women. Smokers of 15+ cigarettes per day had higher levels of all hormones than non-smokers, with the largest difference for testosterone. Drinkers of 20+ g alcohol per day had higher levels of all hormones, but lower SHBG, than non-drinkers, with the largest difference for DHEAS. Hormone concentrations were not strongly related to age at menarche, parity, age at first full-term pregnancy or family history of breast cancer. CONCLUSION: Sex hormone concentrations were strongly associated with several established or suspected risk factors for breast cancer, and may mediate the effects of these factors on breast cancer risk. British Journal of Cancer (2011) 105, 709-722. doi:10.1038/bjc.2011.254 www.bjcancer.com Published online 19 July 2011 (C) 2011 Cancer Research UK (Less)

Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/2160661

author

Key, T. J. ; Appleby, P. N. ; Reeves, G. K. ; Roddam, A. W. ; Helzlsouer, K. J. ; Alberg, A. J. ; Rollison, D. E. ; Dorgan, J. F. ; Brinton, L. A. and Overvad, K. , et al. (More)

Key, T. J. ; Appleby, P. N. ; Reeves, G. K. ; Roddam, A. W. ; Helzlsouer, K. J. ; Alberg, A. J. ; Rollison, D. E. ; Dorgan, J. F. ; Brinton, L. A. ; Overvad, K. ; Kaaks, R. ; Trichopoulou, A. ; Clavel-Chapelon, F. ; Panico, S. ; Duell, E. J. ; Peeters, P. H. M. ; Rinaldi, S. ; Riboli, E. ; Fentiman, I. S. ; Dowsett, M. ; Manjer, Jonas ^LU ; Lenner, P. ; Hallmans, G. ; Baglietto, L. ; English, D. R. ; Giles, G. G. ; Hopper, J. L. ; Severi, G. ; Morris, H. A. ; Koenig, K. ; Zeleniuch-Jacquotte, A. ; Arslan, A. A. ; Toniolo, P. ; Shore, R. E. ; Krogh, V. ; Micheli, A. ; Berrino, F. ; Muti, P. ; Barrett-Connor, E. ; Laughlin, G. A. ; Kabuto, M. ; Akiba, S. ; Stevens, R. G. ; Neriishi, K. ; Land, C. E. ; Cauley, J. A. ; Lui, Li Yung ; Cummings, Steven R. ; Gunter, M. J. ; Rohan, T. E. and Strickler, H. D. (Less)

organization

publishing date

2011

type

Contribution to journal

publication status

published

subject

Cancer and Oncology

keywords

breast cancer, hormones, oestrogens, androgens, sex hormone-binding, globulin

in

British Journal of Cancer

volume

105

issue

5

pages

709 - 722

publisher

Nature Publishing Group

external identifiers

wos:000294207800017
scopus:80052034915
pmid:21772329

ISSN

1532-1827

DOI

10.1038/bjc.2011.254

language

English

LU publication?

yes

id

169040a3-5233-492d-a890-7395026680ab (old id 2160661)

date added to LUP

2016-04-01 10:24:44

date last changed

2022-04-27 21:40:47

@article{169040a3-5233-492d-a890-7395026680ab,
  abstract     = {{BACKGROUND: Breast cancer risk for postmenopausal women is positively associated with circulating concentrations of oestrogens and androgens, but the determinants of these hormones are not well understood. METHODS: Cross-sectional analyses of breast cancer risk factors and circulating hormone concentrations in more than 6000 postmenopausal women controls in 13 prospective studies. RESULTS: Concentrations of all hormones were lower in older than younger women, with the largest difference for dehydroepiandrosterone sulphate (DHEAS), whereas sex hormone-binding globulin (SHBG) was higher in the older women. Androgens were lower in women with bilateral ovariectomy than in naturally postmenopausal women, with the largest difference for free testosterone. All hormones were higher in obese than lean women, with the largest difference for free oestradiol, whereas SHBG was lower in obese women. Smokers of 15+ cigarettes per day had higher levels of all hormones than non-smokers, with the largest difference for testosterone. Drinkers of 20+ g alcohol per day had higher levels of all hormones, but lower SHBG, than non-drinkers, with the largest difference for DHEAS. Hormone concentrations were not strongly related to age at menarche, parity, age at first full-term pregnancy or family history of breast cancer. CONCLUSION: Sex hormone concentrations were strongly associated with several established or suspected risk factors for breast cancer, and may mediate the effects of these factors on breast cancer risk. British Journal of Cancer (2011) 105, 709-722. doi:10.1038/bjc.2011.254 www.bjcancer.com Published online 19 July 2011 (C) 2011 Cancer Research UK}},
  author       = {{Key, T. J. and Appleby, P. N. and Reeves, G. K. and Roddam, A. W. and Helzlsouer, K. J. and Alberg, A. J. and Rollison, D. E. and Dorgan, J. F. and Brinton, L. A. and Overvad, K. and Kaaks, R. and Trichopoulou, A. and Clavel-Chapelon, F. and Panico, S. and Duell, E. J. and Peeters, P. H. M. and Rinaldi, S. and Riboli, E. and Fentiman, I. S. and Dowsett, M. and Manjer, Jonas and Lenner, P. and Hallmans, G. and Baglietto, L. and English, D. R. and Giles, G. G. and Hopper, J. L. and Severi, G. and Morris, H. A. and Koenig, K. and Zeleniuch-Jacquotte, A. and Arslan, A. A. and Toniolo, P. and Shore, R. E. and Krogh, V. and Micheli, A. and Berrino, F. and Muti, P. and Barrett-Connor, E. and Laughlin, G. A. and Kabuto, M. and Akiba, S. and Stevens, R. G. and Neriishi, K. and Land, C. E. and Cauley, J. A. and Lui, Li Yung and Cummings, Steven R. and Gunter, M. J. and Rohan, T. E. and Strickler, H. D.}},
  issn         = {{1532-1827}},
  keywords     = {{breast cancer; hormones; oestrogens; androgens; sex hormone-binding; globulin}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{709--722}},
  publisher    = {{Nature Publishing Group}},
  series       = {{British Journal of Cancer}},
  title        = {{Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies}},
  url          = {{http://dx.doi.org/10.1038/bjc.2011.254}},
  doi          = {{10.1038/bjc.2011.254}},
  volume       = {{105}},
  year         = {{2011}},
}

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Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies