Graft-Induced Dyskinesias in Parkinson's Disease: High Striatal Serotonin/Dopamine Transporter Ratio
Politis, Marios ; Oertel, Wolfgang H. ; Wu, Kit ; Quinn, Niall P. ; Pogarell, Oliver ; Brooks, David J. ; Björklund, Anders LU
; Lindvall, Olle
LU
and Piccini, Paola
(2011)
In Movement Disorders
26(11).
p.1997-2003
- Abstract
- Graft-induced dyskinesias are a serious complication after neural transplantation in Parkinson's disease. One patient with Parkinson's disease, treated with fetal grafts 14 years ago and deep brain stimulation 6 years ago, showed marked improvement of motor symptoms but continued to suffer from OFF-medication graft-induced dyskinesias. The patient received a series of clinical and imaging assessments. Positron emission tomography and single-photon emission computed tomography 14 years posttransplantation revealed an elevated serotonin/dopamine transporter ratio in the grafted striatum compatible with serotonergic hyperinnervation. Inhibition of serotonin neuron activity by systemic administration of a 5-HT1A agonist suppressed... (More)
- Graft-induced dyskinesias are a serious complication after neural transplantation in Parkinson's disease. One patient with Parkinson's disease, treated with fetal grafts 14 years ago and deep brain stimulation 6 years ago, showed marked improvement of motor symptoms but continued to suffer from OFF-medication graft-induced dyskinesias. The patient received a series of clinical and imaging assessments. Positron emission tomography and single-photon emission computed tomography 14 years posttransplantation revealed an elevated serotonin/dopamine transporter ratio in the grafted striatum compatible with serotonergic hyperinnervation. Inhibition of serotonin neuron activity by systemic administration of a 5-HT1A agonist suppressed graft-induced dyskinesias. Our data provide further evidence that serotonergic neurons mediate graft-induced dyskinesias in Parkinson's disease. Achieving a normal striatal serotonin/dopamine transporter ratio following transplantation of fetal tissue or stem cells should be necessary to avoid the development of graft-induced dyskinesias. (C) 2011 Movement Disorder Society (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2211682
- author
- Politis, Marios
; Oertel, Wolfgang H.
; Wu, Kit
; Quinn, Niall P.
; Pogarell, Oliver
; Brooks, David J.
; Björklund, Anders
LU
; Lindvall, Olle
LU
and Piccini, Paola
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Parkinson, transplantation, dyskinesias, serotonin transporter, dopamine transporter
- in
- Movement Disorders
- volume
- 26
- issue
- 11
- pages
- 1997 - 2003
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000295456300008
- scopus:80052971467
- pmid:21611977
- ISSN
- 0885-3185
- DOI
- 10.1002/mds.23743
- language
- English
- LU publication?
- yes
- id
- 49e357ef-141b-4583-a82a-6fd4c05ae5ad (old id 2211682)
- date added to LUP
- 2016-04-01 10:52:55
- date last changed
- 2022-04-12 18:35:32
@article{49e357ef-141b-4583-a82a-6fd4c05ae5ad,
abstract = {{Graft-induced dyskinesias are a serious complication after neural transplantation in Parkinson's disease. One patient with Parkinson's disease, treated with fetal grafts 14 years ago and deep brain stimulation 6 years ago, showed marked improvement of motor symptoms but continued to suffer from OFF-medication graft-induced dyskinesias. The patient received a series of clinical and imaging assessments. Positron emission tomography and single-photon emission computed tomography 14 years posttransplantation revealed an elevated serotonin/dopamine transporter ratio in the grafted striatum compatible with serotonergic hyperinnervation. Inhibition of serotonin neuron activity by systemic administration of a 5-HT1A agonist suppressed graft-induced dyskinesias. Our data provide further evidence that serotonergic neurons mediate graft-induced dyskinesias in Parkinson's disease. Achieving a normal striatal serotonin/dopamine transporter ratio following transplantation of fetal tissue or stem cells should be necessary to avoid the development of graft-induced dyskinesias. (C) 2011 Movement Disorder Society}},
author = {{Politis, Marios and Oertel, Wolfgang H. and Wu, Kit and Quinn, Niall P. and Pogarell, Oliver and Brooks, David J. and Björklund, Anders and Lindvall, Olle and Piccini, Paola}},
issn = {{0885-3185}},
keywords = {{Parkinson; transplantation; dyskinesias; serotonin transporter; dopamine transporter}},
language = {{eng}},
number = {{11}},
pages = {{1997--2003}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Movement Disorders}},
title = {{Graft-Induced Dyskinesias in Parkinson's Disease: High Striatal Serotonin/Dopamine Transporter Ratio}},
url = {{http://dx.doi.org/10.1002/mds.23743}},
doi = {{10.1002/mds.23743}},
volume = {{26}},
year = {{2011}},
}