Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Relations between pig growth and regulatory mechanism of pancreas - facts and hypotheses

Pierzynowski, Stefan LU ; Kruszewska, Danuta LU ; Rengman, Sofia LU ; Fedkiv, Olexandr LU ; Dabek, M ; Hotowy, A ; Werpachowska, E and Weström, Björn LU (2005) In Journal of Animal and Feed Sciences 14(Suppl 1). p.139-144
Abstract
The aim of the mini review is to more precisely determine the relationship between exocrine pancreas function and the growth of young pigs. In order to do so, it is necessary to clarify the components, pathways and messengers involved in the CCK-dependent neuro-hormonal regulation of the exocrine pancreas in the growing pigs. These mechanisms are largely unknown, and the role of CCK has been questioned since CCK receptors on the enzyme producing acinar cells are lacking. Our hitherto obtained results have shown the importance of CCK for the pancreatic enzyme secretion and that in pigs CCK functions via CCK-B receptor-mediated entero(duodenal)-pancreatic reflex and via CCK-A receptor mechanism which localization is unknown. Preliminary... (More)
The aim of the mini review is to more precisely determine the relationship between exocrine pancreas function and the growth of young pigs. In order to do so, it is necessary to clarify the components, pathways and messengers involved in the CCK-dependent neuro-hormonal regulation of the exocrine pancreas in the growing pigs. These mechanisms are largely unknown, and the role of CCK has been questioned since CCK receptors on the enzyme producing acinar cells are lacking. Our hitherto obtained results have shown the importance of CCK for the pancreatic enzyme secretion and that in pigs CCK functions via CCK-B receptor-mediated entero(duodenal)-pancreatic reflex and via CCK-A receptor mechanism which localization is unknown. Preliminary studies have indicated this later mechanism as being related to the growth performance of pigs. The planned studies will comprise a pharmacologic characterization and an immunohistologic localization of the components and messengers involved in the CCK-dependent neuro-hormonal pancreatic regulation using an appropriately catheterized pig model. Since the applied aim of the project is to correlate the growth of the pigs to the effectiveness of the pancreatic secretion and to the development of its regulatory mechanisms, the experiments will be performed on pigs having different growth and performance. It is expected that the discussion will provide important applicable understanding of pancreatic function and its impact on pig growth and performance and also highlight the mechanism of the inter-organ regulatory pathways of the exocrine pancreatic function. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
pig growth, regulatory mechanism, pancreas
in
Journal of Animal and Feed Sciences
volume
14
issue
Suppl 1
pages
139 - 144
publisher
KIELANOWSKI INST ANIMAL PHYSIOLOGY NUTRITION
external identifiers
  • wos:000230495000009
  • scopus:24944506744
ISSN
1230-1388
language
English
LU publication?
yes
id
a575e7dc-1163-4b7e-b177-f95117c074e5 (old id 233087)
date added to LUP
2016-04-01 15:38:15
date last changed
2022-01-28 06:21:58
@article{a575e7dc-1163-4b7e-b177-f95117c074e5,
  abstract     = {{The aim of the mini review is to more precisely determine the relationship between exocrine pancreas function and the growth of young pigs. In order to do so, it is necessary to clarify the components, pathways and messengers involved in the CCK-dependent neuro-hormonal regulation of the exocrine pancreas in the growing pigs. These mechanisms are largely unknown, and the role of CCK has been questioned since CCK receptors on the enzyme producing acinar cells are lacking. Our hitherto obtained results have shown the importance of CCK for the pancreatic enzyme secretion and that in pigs CCK functions via CCK-B receptor-mediated entero(duodenal)-pancreatic reflex and via CCK-A receptor mechanism which localization is unknown. Preliminary studies have indicated this later mechanism as being related to the growth performance of pigs. The planned studies will comprise a pharmacologic characterization and an immunohistologic localization of the components and messengers involved in the CCK-dependent neuro-hormonal pancreatic regulation using an appropriately catheterized pig model. Since the applied aim of the project is to correlate the growth of the pigs to the effectiveness of the pancreatic secretion and to the development of its regulatory mechanisms, the experiments will be performed on pigs having different growth and performance. It is expected that the discussion will provide important applicable understanding of pancreatic function and its impact on pig growth and performance and also highlight the mechanism of the inter-organ regulatory pathways of the exocrine pancreatic function.}},
  author       = {{Pierzynowski, Stefan and Kruszewska, Danuta and Rengman, Sofia and Fedkiv, Olexandr and Dabek, M and Hotowy, A and Werpachowska, E and Weström, Björn}},
  issn         = {{1230-1388}},
  keywords     = {{pig growth; regulatory mechanism; pancreas}},
  language     = {{eng}},
  number       = {{Suppl 1}},
  pages        = {{139--144}},
  publisher    = {{KIELANOWSKI INST ANIMAL PHYSIOLOGY NUTRITION}},
  series       = {{Journal of Animal and Feed Sciences}},
  title        = {{Relations between pig growth and regulatory mechanism of pancreas - facts and hypotheses}},
  volume       = {{14}},
  year         = {{2005}},
}