Evaluation of Plasma A beta as Predictor of Alzheimer's Disease in Older Individuals Without Dementia: A Population-Based Study
Hansson, Oskar LU
; Stomrud, Erik
LU
; Vanmechelen, Eugeen
; Ostling, Svante
; Gustafson, Deborah R.
; Zetterberg, Henrik
; Blennow, Kaj
and Skoog, Ingmar
(2012)
In Journal of Alzheimer's Disease
28(1).
p.231-238
- Abstract
- Amyloid-beta (A beta) pathology is a major component in the mechanisms behind Alzheimer's disease (AD). Measurement of A beta(42) in cerebrospinal fluid predicts cognitive decline in patients with mild cognitive impairment and identifies AD in patients with dementia. However, studies on A beta in plasma are contradictory. In this prospective population-based study, plasma A beta(42) and A beta(40) were measured at baseline in 730 adults aged 70 years or older and without dementia. After five years, plasma levels were analyzed again and participants were assessed for development of dementia. During follow-up, 53 individuals (7%) developed dementia of which 37 (5%) were classified as AD. No difference in baseline plasma A beta(42), A... (More)
- Amyloid-beta (A beta) pathology is a major component in the mechanisms behind Alzheimer's disease (AD). Measurement of A beta(42) in cerebrospinal fluid predicts cognitive decline in patients with mild cognitive impairment and identifies AD in patients with dementia. However, studies on A beta in plasma are contradictory. In this prospective population-based study, plasma A beta(42) and A beta(40) were measured at baseline in 730 adults aged 70 years or older and without dementia. After five years, plasma levels were analyzed again and participants were assessed for development of dementia. During follow-up, 53 individuals (7%) developed dementia of which 37 (5%) were classified as AD. No difference in baseline plasma A beta(42), A beta(40), or A beta(42)/A beta(40) ratio levels were observed between converters to dementia or AD compared to the cognitively stable individuals. However, individuals with plasma A beta(40) levels above the median level for the group at baseline had an increased risk of developing dementia and AD during the follow-up, even after adjustment for age, gender, APOE genotype, and educational level (odds ratio = 2.2, 95% confidence interval = 1.0-4.7, p < 0.05). Neither plasma A beta(42) nor the A beta(42)/A beta(40) ratio influenced the risk of developing dementia or AD. Moreover, A beta(42) and A beta(40) levels increased over the 5 years, whereas the A beta(42)/A beta(40) ratio decreased (p < 0.001). In conclusion, this study suggests that measurement of plasma A beta should not be used clinically to predict dementia or AD. However, plasma A beta(40) may possibly be regarded as a moderate risk marker comparable to other risk markers for AD such as first-degree family history of dementia. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2355076
- author
- Hansson, Oskar
LU
; Stomrud, Erik
LU
; Vanmechelen, Eugeen
; Ostling, Svante
; Gustafson, Deborah R.
; Zetterberg, Henrik
; Blennow, Kaj
and Skoog, Ingmar
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Alzheimer's disease, amyloid-beta 40, amyloid-beta 42, biological, markers, cohort studies, dementia, plasma
- in
- Journal of Alzheimer's Disease
- volume
- 28
- issue
- 1
- pages
- 231 - 238
- publisher
- IOS Press
- external identifiers
-
- wos:000299311900020
- scopus:84855759192
- ISSN
- 1387-2877
- DOI
- 10.3233/JAD-2011-111418
- language
- English
- LU publication?
- yes
- id
- db6919d5-c678-4189-ae72-9ca5c7b1ea16 (old id 2355076)
- date added to LUP
- 2016-04-01 10:44:26
- date last changed
- 2023-11-10 04:18:35
@article{db6919d5-c678-4189-ae72-9ca5c7b1ea16,
abstract = {{Amyloid-beta (A beta) pathology is a major component in the mechanisms behind Alzheimer's disease (AD). Measurement of A beta(42) in cerebrospinal fluid predicts cognitive decline in patients with mild cognitive impairment and identifies AD in patients with dementia. However, studies on A beta in plasma are contradictory. In this prospective population-based study, plasma A beta(42) and A beta(40) were measured at baseline in 730 adults aged 70 years or older and without dementia. After five years, plasma levels were analyzed again and participants were assessed for development of dementia. During follow-up, 53 individuals (7%) developed dementia of which 37 (5%) were classified as AD. No difference in baseline plasma A beta(42), A beta(40), or A beta(42)/A beta(40) ratio levels were observed between converters to dementia or AD compared to the cognitively stable individuals. However, individuals with plasma A beta(40) levels above the median level for the group at baseline had an increased risk of developing dementia and AD during the follow-up, even after adjustment for age, gender, APOE genotype, and educational level (odds ratio = 2.2, 95% confidence interval = 1.0-4.7, p < 0.05). Neither plasma A beta(42) nor the A beta(42)/A beta(40) ratio influenced the risk of developing dementia or AD. Moreover, A beta(42) and A beta(40) levels increased over the 5 years, whereas the A beta(42)/A beta(40) ratio decreased (p < 0.001). In conclusion, this study suggests that measurement of plasma A beta should not be used clinically to predict dementia or AD. However, plasma A beta(40) may possibly be regarded as a moderate risk marker comparable to other risk markers for AD such as first-degree family history of dementia.}},
author = {{Hansson, Oskar and Stomrud, Erik and Vanmechelen, Eugeen and Ostling, Svante and Gustafson, Deborah R. and Zetterberg, Henrik and Blennow, Kaj and Skoog, Ingmar}},
issn = {{1387-2877}},
keywords = {{Alzheimer's disease; amyloid-beta 40; amyloid-beta 42; biological; markers; cohort studies; dementia; plasma}},
language = {{eng}},
number = {{1}},
pages = {{231--238}},
publisher = {{IOS Press}},
series = {{Journal of Alzheimer's Disease}},
title = {{Evaluation of Plasma A beta as Predictor of Alzheimer's Disease in Older Individuals Without Dementia: A Population-Based Study}},
url = {{https://lup.lub.lu.se/search/files/2095378/2438639.pdf}},
doi = {{10.3233/JAD-2011-111418}},
volume = {{28}},
year = {{2012}},
}