Impact of maternal characteristics on fetal growth in the third trimester: a population-based study
(2012) In Ultrasound in Obstetrics and Gynecology 40(6). p.680-687- Abstract
- Objectives. To investigate the association between maternal characteristics and fetal growth during the third trimester of pregnancy. Methods. Using a population-based perinatal register, 48,809 term singleton pregnancies were identified for which a routine ultrasound examination in the third trimester was performed between 1995 and 2009. Fetal and infant weight, respectively, were expressed as gestational age specific standard deviation scores (z-scores) using a Swedish ultrasound-based reference curve. The growth of each fetus was assessed using the difference between the birth weight z-score and the fetal weight z-score estimated at the ultrasound examination, adjusted for gestational age, and divided by the time elapsed between the... (More)
- Objectives. To investigate the association between maternal characteristics and fetal growth during the third trimester of pregnancy. Methods. Using a population-based perinatal register, 48,809 term singleton pregnancies were identified for which a routine ultrasound examination in the third trimester was performed between 1995 and 2009. Fetal and infant weight, respectively, were expressed as gestational age specific standard deviation scores (z-scores) using a Swedish ultrasound-based reference curve. The growth of each fetus was assessed using the difference between the birth weight z-score and the fetal weight z-score estimated at the ultrasound examination, adjusted for gestational age, and divided by the time elapsed between the ultrasound examination and birth. Analyses were performed using multivariate linear and polynomial regression analyses. Results. Positive associations were found between maternal body mass index (BMI), height, preexisting diabetes mellitus, and a high fetal growth, whereas maternal smoking had a negative impact. In the univariate analyses, primiparity and grand multiparity (≥4 previous children) were significantly associated with a reduced fetal growth, but in the multivariate analysis, no association between parity and fetal growth could be detected. Both the univariate and the multivariate analyses revealed a significant inverse u-shaped association between maternal age and fetal growth. Conclusions. Fetal third trimester growth was positively associated with increasing maternal BMI, height, and pre-existing diabetes mellitus, and was negatively associated with maternal smoking. No significant association between fetal growth and maternal parity or gestational diabetes mellitus was detected when adjustments were made for gestational age and the other maternal characteristics. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2367337
- author
- Lindell, Gun LU ; Marsal, Karel LU and Källén, Karin LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ultrasound, maternal characteristics, intrauterine growth, fetal gender, fetus
- in
- Ultrasound in Obstetrics and Gynecology
- volume
- 40
- issue
- 6
- pages
- 680 - 687
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000311857700013
- pmid:22302307
- scopus:84870533794
- ISSN
- 1469-0705
- DOI
- 10.1002/uog.11125
- language
- English
- LU publication?
- yes
- id
- 03218367-cbb2-49f8-9399-be7561222635 (old id 2367337)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22302307?dopt=Abstract
- date added to LUP
- 2016-04-01 14:51:47
- date last changed
- 2022-02-12 05:54:15
@article{03218367-cbb2-49f8-9399-be7561222635,
abstract = {{Objectives. To investigate the association between maternal characteristics and fetal growth during the third trimester of pregnancy. Methods. Using a population-based perinatal register, 48,809 term singleton pregnancies were identified for which a routine ultrasound examination in the third trimester was performed between 1995 and 2009. Fetal and infant weight, respectively, were expressed as gestational age specific standard deviation scores (z-scores) using a Swedish ultrasound-based reference curve. The growth of each fetus was assessed using the difference between the birth weight z-score and the fetal weight z-score estimated at the ultrasound examination, adjusted for gestational age, and divided by the time elapsed between the ultrasound examination and birth. Analyses were performed using multivariate linear and polynomial regression analyses. Results. Positive associations were found between maternal body mass index (BMI), height, preexisting diabetes mellitus, and a high fetal growth, whereas maternal smoking had a negative impact. In the univariate analyses, primiparity and grand multiparity (≥4 previous children) were significantly associated with a reduced fetal growth, but in the multivariate analysis, no association between parity and fetal growth could be detected. Both the univariate and the multivariate analyses revealed a significant inverse u-shaped association between maternal age and fetal growth. Conclusions. Fetal third trimester growth was positively associated with increasing maternal BMI, height, and pre-existing diabetes mellitus, and was negatively associated with maternal smoking. No significant association between fetal growth and maternal parity or gestational diabetes mellitus was detected when adjustments were made for gestational age and the other maternal characteristics. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.}},
author = {{Lindell, Gun and Marsal, Karel and Källén, Karin}},
issn = {{1469-0705}},
keywords = {{ultrasound; maternal characteristics; intrauterine growth; fetal gender; fetus}},
language = {{eng}},
number = {{6}},
pages = {{680--687}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Ultrasound in Obstetrics and Gynecology}},
title = {{Impact of maternal characteristics on fetal growth in the third trimester: a population-based study}},
url = {{http://dx.doi.org/10.1002/uog.11125}},
doi = {{10.1002/uog.11125}},
volume = {{40}},
year = {{2012}},
}