Deoxyribonucleoside kinases: two enzyme families catalyze the same reaction
(2005) In Trends in Biochemical Sciences 30(5). p.225-228- Abstract
- Mammals have four deoxyribonucleoside kinases, the cytoplasmic (TK1) and mitochondrial (TK2) thymidine kinases, and the deoxycytidine (dCK) and deoxyguanosine (dGK) kinases, which salvage the precursors for nucleic acids synthesis. In addition to the native deoxyribonucleoside substrates, the kinases can phosphorylate and thereby activate a variety of anti-cancer and antiviral prodrugs. Recently, the crystal structure of human TK1 has been solved and has revealed that enzymes with fundamentally different origins and folds catalyze similar, crucial cellular reactions.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/237654
- author
- Sandrini, Michael LU and Piskur, Jure LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Biochemical Sciences
- volume
- 30
- issue
- 5
- pages
- 225 - 228
- publisher
- Elsevier
- external identifiers
-
- wos:000229466300003
- pmid:15896737
- scopus:18844367487
- ISSN
- 0167-7640
- DOI
- 10.1016/j.tibs.2005.03.003
- language
- English
- LU publication?
- yes
- id
- 1a04644f-f06f-4377-8efc-757054c053d2 (old id 237654)
- date added to LUP
- 2016-04-01 12:09:17
- date last changed
- 2022-01-26 23:36:18
@article{1a04644f-f06f-4377-8efc-757054c053d2, abstract = {{Mammals have four deoxyribonucleoside kinases, the cytoplasmic (TK1) and mitochondrial (TK2) thymidine kinases, and the deoxycytidine (dCK) and deoxyguanosine (dGK) kinases, which salvage the precursors for nucleic acids synthesis. In addition to the native deoxyribonucleoside substrates, the kinases can phosphorylate and thereby activate a variety of anti-cancer and antiviral prodrugs. Recently, the crystal structure of human TK1 has been solved and has revealed that enzymes with fundamentally different origins and folds catalyze similar, crucial cellular reactions.}}, author = {{Sandrini, Michael and Piskur, Jure}}, issn = {{0167-7640}}, language = {{eng}}, number = {{5}}, pages = {{225--228}}, publisher = {{Elsevier}}, series = {{Trends in Biochemical Sciences}}, title = {{Deoxyribonucleoside kinases: two enzyme families catalyze the same reaction}}, url = {{http://dx.doi.org/10.1016/j.tibs.2005.03.003}}, doi = {{10.1016/j.tibs.2005.03.003}}, volume = {{30}}, year = {{2005}}, }