Increased Urine IgM and IgG(2) Levels, Indicating Decreased Glomerular Size Selectivity, Are Not Affected by Dalteparin Therapy in Patients with Type 2 Diabetes.
(2012) In Biochemistry Research International 2012.- Abstract
- Fifty-four type 2 diabetic patients with neuroischemic foot ulcers were randomised to treatment with 5000 IU of dalteparin, (n = 28), or physiological saline, (n = 26), once daily until ulcer healing or for a maximum of 6 months. Thirty-three patients had normo-, 15 micro-, and 6 macroalbuminuria. The urinary levels of IgM and IgG(2) were elevated in 47 and 50 patients, respectively. Elevated urinary levels of IgM and IgG(2) indicate decreased glomerular size selectivity. Urine IgM levels were associated with IGF-1/IGFBP-1 and IGFBP-1 levels. Dalteparin treatment increased urinary levels of glycosaminoglycans (P < 0.001) and serum IGFBP-1 (P < 0.05) while no significant effects were seen in any of the other studied parameters. In... (More)
- Fifty-four type 2 diabetic patients with neuroischemic foot ulcers were randomised to treatment with 5000 IU of dalteparin, (n = 28), or physiological saline, (n = 26), once daily until ulcer healing or for a maximum of 6 months. Thirty-three patients had normo-, 15 micro-, and 6 macroalbuminuria. The urinary levels of IgM and IgG(2) were elevated in 47 and 50 patients, respectively. Elevated urinary levels of IgM and IgG(2) indicate decreased glomerular size selectivity. Urine IgM levels were associated with IGF-1/IGFBP-1 and IGFBP-1 levels. Dalteparin treatment increased urinary levels of glycosaminoglycans (P < 0.001) and serum IGFBP-1 (P < 0.05) while no significant effects were seen in any of the other studied parameters. In conclusion, dalteparin therapy in patients with type 2 diabetes had no effects on urinary levels of albumin, IgM, or IgG(2) despite significantly increased glycosaminoglycans in urine. Elevated urinary levels of IgM and IgG(2) might be more sensitive markers of renal disease than albuminuria in patients with type 2 diabetes and antihypertensive therapy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2432139
- author
- Torffvit, Ole LU ; Kalani, Majid ; Apelqvist, Jan LU ; Eliasson, Björn ; Eriksson, Jan W ; Brismar, Kerstin and Jörneskog, Gun
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biochemistry Research International
- volume
- 2012
- article number
- 480529
- publisher
- Hindawi Limited
- external identifiers
-
- pmid:22400116
- scopus:84858300929
- pmid:22400116
- ISSN
- 2090-2247
- DOI
- 10.1155/2012/480529
- language
- English
- LU publication?
- yes
- id
- ceaf5c21-9406-4692-ba33-21abec3e217d (old id 2432139)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22400116?dopt=Abstract
- date added to LUP
- 2016-04-01 10:16:33
- date last changed
- 2024-01-06 12:29:46
@article{ceaf5c21-9406-4692-ba33-21abec3e217d, abstract = {{Fifty-four type 2 diabetic patients with neuroischemic foot ulcers were randomised to treatment with 5000 IU of dalteparin, (n = 28), or physiological saline, (n = 26), once daily until ulcer healing or for a maximum of 6 months. Thirty-three patients had normo-, 15 micro-, and 6 macroalbuminuria. The urinary levels of IgM and IgG(2) were elevated in 47 and 50 patients, respectively. Elevated urinary levels of IgM and IgG(2) indicate decreased glomerular size selectivity. Urine IgM levels were associated with IGF-1/IGFBP-1 and IGFBP-1 levels. Dalteparin treatment increased urinary levels of glycosaminoglycans (P < 0.001) and serum IGFBP-1 (P < 0.05) while no significant effects were seen in any of the other studied parameters. In conclusion, dalteparin therapy in patients with type 2 diabetes had no effects on urinary levels of albumin, IgM, or IgG(2) despite significantly increased glycosaminoglycans in urine. Elevated urinary levels of IgM and IgG(2) might be more sensitive markers of renal disease than albuminuria in patients with type 2 diabetes and antihypertensive therapy.}}, author = {{Torffvit, Ole and Kalani, Majid and Apelqvist, Jan and Eliasson, Björn and Eriksson, Jan W and Brismar, Kerstin and Jörneskog, Gun}}, issn = {{2090-2247}}, language = {{eng}}, publisher = {{Hindawi Limited}}, series = {{Biochemistry Research International}}, title = {{Increased Urine IgM and IgG(2) Levels, Indicating Decreased Glomerular Size Selectivity, Are Not Affected by Dalteparin Therapy in Patients with Type 2 Diabetes.}}, url = {{https://lup.lub.lu.se/search/files/1707825/2856124.pdf}}, doi = {{10.1155/2012/480529}}, volume = {{2012}}, year = {{2012}}, }