Two genome-wide linkage disequilibrium screens in Scandinavian multiple sclerosis patients
(2003) In Journal of Neuroimmunology 143(1-2). p.101-106- Abstract
- We report the first two genome-wide screens for linkage disequilibrium between putative multiple sclerosis (MS) susceptibility genes and genetic markers performed in the genetically homogenous Scandinavian population, using 6000 microsatellite markers and DNA pools of approximately 200 MS cases and 200 controls in each screen. Usable data were achieved from the same 3331 markers in both screens. Nine markers from eight genomic regions (1p33, 3q13, 6p21, 6q14, 7p22, 9p21, 9q21 and Xq22) were identified as potentially associated with MS in both screens. (C) 2003 Elsevier B.V. All rights reserved.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/294952
- author
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Scandinavia, multiple sclerosis, genome screen, linkage disequilibrium, DNA pooling
- in
- Journal of Neuroimmunology
- volume
- 143
- issue
- 1-2
- pages
- 101 - 106
- publisher
- Elsevier
- external identifiers
-
- pmid:14575924
- wos:000186539300020
- scopus:10744228501
- ISSN
- 1872-8421
- DOI
- 10.1016/j.jneuroim.2003.08.021
- language
- English
- LU publication?
- yes
- id
- b915bd61-3b5e-4807-bebb-9bc5ed42f095 (old id 294952)
- date added to LUP
- 2016-04-01 12:02:17
- date last changed
- 2022-01-26 21:56:13
@article{b915bd61-3b5e-4807-bebb-9bc5ed42f095, abstract = {{We report the first two genome-wide screens for linkage disequilibrium between putative multiple sclerosis (MS) susceptibility genes and genetic markers performed in the genetically homogenous Scandinavian population, using 6000 microsatellite markers and DNA pools of approximately 200 MS cases and 200 controls in each screen. Usable data were achieved from the same 3331 markers in both screens. Nine markers from eight genomic regions (1p33, 3q13, 6p21, 6q14, 7p22, 9p21, 9q21 and Xq22) were identified as potentially associated with MS in both screens. (C) 2003 Elsevier B.V. All rights reserved.}}, author = {{Harbo, HF and Datta, P and Oturai, A and Ryder, LP and Sawcer, S and Setakis, E and Akesson, E and Celius, EG and Modin, H and Sandberg Wollheim, Magnhild and Myhr, KM and Andersen, O and Hillert, J and Sorensen, PS and Svejgaard, A and Compston, A and Vartdal, F and Spurkland, A}}, issn = {{1872-8421}}, keywords = {{Scandinavia; multiple sclerosis; genome screen; linkage disequilibrium; DNA pooling}}, language = {{eng}}, number = {{1-2}}, pages = {{101--106}}, publisher = {{Elsevier}}, series = {{Journal of Neuroimmunology}}, title = {{Two genome-wide linkage disequilibrium screens in Scandinavian multiple sclerosis patients}}, url = {{http://dx.doi.org/10.1016/j.jneuroim.2003.08.021}}, doi = {{10.1016/j.jneuroim.2003.08.021}}, volume = {{143}}, year = {{2003}}, }