Stability analysis of an artificial biomolecular oscillator with non-cooperative regulatory interactions
(2017) In Journal of Biological Dynamics 11(1). p.102-120- Abstract
- Oscillators are essential to fuel autonomous behaviours in molecular systems. Artificial oscillators built with programmable biological molecules such as DNA and RNA are generally easy to build and tune, and can serve as timers for biological computation and regulation. We describe a new artificial nucleic acid biochemical reaction network, and we demonstrate its capacity to exhibit oscillatory solutions. This network can be built in vitro using nucleic acids and three bacteriophage enzymes, and has the potential to be implemented in cells. Numerical simulations suggest that oscillations occur in a realistic range of reaction rates and concentrations.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/29f14cae-527b-4ccf-b174-a720d3c8f1aa
- author
- Cuba Samaniego, Christian ; Giordano, Giulia LU ; Blanchini, Franco and Franco, Elisa
- organization
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Biological Dynamics
- volume
- 11
- issue
- 1
- pages
- 19 pages
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:27830588
- scopus:84995957112
- wos:000389042600002
- ISSN
- 1751-3766
- DOI
- 10.1080/17513758.2016.1245790
- language
- English
- LU publication?
- yes
- additional info
- PMID: 27830588
- id
- 29f14cae-527b-4ccf-b174-a720d3c8f1aa
- date added to LUP
- 2016-11-26 15:00:30
- date last changed
- 2024-05-31 18:01:51
@article{29f14cae-527b-4ccf-b174-a720d3c8f1aa, abstract = {{Oscillators are essential to fuel autonomous behaviours in molecular systems. Artificial oscillators built with programmable biological molecules such as DNA and RNA are generally easy to build and tune, and can serve as timers for biological computation and regulation. We describe a new artificial nucleic acid biochemical reaction network, and we demonstrate its capacity to exhibit oscillatory solutions. This network can be built in vitro using nucleic acids and three bacteriophage enzymes, and has the potential to be implemented in cells. Numerical simulations suggest that oscillations occur in a realistic range of reaction rates and concentrations.}}, author = {{Cuba Samaniego, Christian and Giordano, Giulia and Blanchini, Franco and Franco, Elisa}}, issn = {{1751-3766}}, language = {{eng}}, number = {{1}}, pages = {{102--120}}, publisher = {{Taylor & Francis}}, series = {{Journal of Biological Dynamics}}, title = {{Stability analysis of an artificial biomolecular oscillator with non-cooperative regulatory interactions}}, url = {{http://dx.doi.org/10.1080/17513758.2016.1245790}}, doi = {{10.1080/17513758.2016.1245790}}, volume = {{11}}, year = {{2017}}, }