Premedication for intubation with morphine causes prolonged depression of electrocortical background activity in preterm infants.
Norman, Elisabeth LU ; Wikström, Sverre ; Rosén, Ingmar LU ; Fellman, Vineta LU
and Hellström-Westas, Lena
LU
(2013)
In Pediatric Research
73.
p.87-94
- Abstract
- Background:Sedative and analgesic medications are used in critically ill newborns, but little is known about their effects on electrocortical activity in preterm infants. We hypothesized that morphine might induce prolonged neurodepression, independent of blood pressure, compared with rapid sequence induction/intubation (RSI).Methods:Of 34 infants enrolled into a randomized controlled trial (RCT) comparing RSI (including thiopental 2-3 mg/kg and remifentantil 1 microg/kg) with morphine (0.3 mg/kg) as premedication for intubation, 28 infants (n=14+14; median gestational age 26.1 weeks and postnatal age 138 h) had continuous two-channel amplitude-integrated electroencephalogram (aEEG/EEG) and blood pressure monitoring during 24 h after the... (More)
- Background:Sedative and analgesic medications are used in critically ill newborns, but little is known about their effects on electrocortical activity in preterm infants. We hypothesized that morphine might induce prolonged neurodepression, independent of blood pressure, compared with rapid sequence induction/intubation (RSI).Methods:Of 34 infants enrolled into a randomized controlled trial (RCT) comparing RSI (including thiopental 2-3 mg/kg and remifentantil 1 microg/kg) with morphine (0.3 mg/kg) as premedication for intubation, 28 infants (n=14+14; median gestational age 26.1 weeks and postnatal age 138 h) had continuous two-channel amplitude-integrated electroencephalogram (aEEG/EEG) and blood pressure monitoring during 24 h after the intubation. Thirteen infants not receiving any additional medication constituted the primary study group. Visual and quantitative analyses of aEEG/EEG and blood pressure were performed in 3-h epochs.Results:RSI was associated with aEEG/EEG depression lasting less than 3 h. Morphine premedication resulted in aEEG/EEG depression with more discontinuous background and less developed cyclicity for 24 h, and during the first 9 h interburst intervals were significantly increased compared to RSI. The difference was not related to blood pressure.Conclusion:Premedication with morphine is associated with prolonged aEEG/EEG depression independent of blood pressure changes, and may not be optimal for short procedures.Pediatric Research (2012); doi:10.1038/pr.2012.153. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3219219
- author
- Norman, Elisabeth
LU
; Wikström, Sverre
; Rosén, Ingmar
LU
; Fellman, Vineta
LU
and Hellström-Westas, Lena
LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pediatric Research
- volume
- 73
- pages
- 87 - 94
- publisher
- International Pediatric Foundation Inc.
- external identifiers
-
- wos:000313307900014
- pmid:23128421
- scopus:84872059584
- ISSN
- 1530-0447
- DOI
- 10.1038/pr.2012.153
- language
- English
- LU publication?
- yes
- id
- 8a010d47-6cab-40d6-af79-5fba67cdbab6 (old id 3219219)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23128421?dopt=Abstract
- date added to LUP
- 2016-04-01 10:24:49
- date last changed
- 2022-01-25 22:58:09
@article{8a010d47-6cab-40d6-af79-5fba67cdbab6,
abstract = {{Background:Sedative and analgesic medications are used in critically ill newborns, but little is known about their effects on electrocortical activity in preterm infants. We hypothesized that morphine might induce prolonged neurodepression, independent of blood pressure, compared with rapid sequence induction/intubation (RSI).Methods:Of 34 infants enrolled into a randomized controlled trial (RCT) comparing RSI (including thiopental 2-3 mg/kg and remifentantil 1 microg/kg) with morphine (0.3 mg/kg) as premedication for intubation, 28 infants (n=14+14; median gestational age 26.1 weeks and postnatal age 138 h) had continuous two-channel amplitude-integrated electroencephalogram (aEEG/EEG) and blood pressure monitoring during 24 h after the intubation. Thirteen infants not receiving any additional medication constituted the primary study group. Visual and quantitative analyses of aEEG/EEG and blood pressure were performed in 3-h epochs.Results:RSI was associated with aEEG/EEG depression lasting less than 3 h. Morphine premedication resulted in aEEG/EEG depression with more discontinuous background and less developed cyclicity for 24 h, and during the first 9 h interburst intervals were significantly increased compared to RSI. The difference was not related to blood pressure.Conclusion:Premedication with morphine is associated with prolonged aEEG/EEG depression independent of blood pressure changes, and may not be optimal for short procedures.Pediatric Research (2012); doi:10.1038/pr.2012.153.}},
author = {{Norman, Elisabeth and Wikström, Sverre and Rosén, Ingmar and Fellman, Vineta and Hellström-Westas, Lena}},
issn = {{1530-0447}},
language = {{eng}},
pages = {{87--94}},
publisher = {{International Pediatric Foundation Inc.}},
series = {{Pediatric Research}},
title = {{Premedication for intubation with morphine causes prolonged depression of electrocortical background activity in preterm infants.}},
url = {{https://lup.lub.lu.se/search/files/1822378/3738680.pdf}},
doi = {{10.1038/pr.2012.153}},
volume = {{73}},
year = {{2013}},
}